Zobrazeno 1 - 10 of 31 pro vyhledávání: '"John K Meissen"'
1
Bioanalytical Methods and Strategic Perspectives Addressing the Rising Complexity of Novel Bioconjugates and Delivery Routes for Biotherapeutics
Autor: Ruipeng Mu, Jiaqi Yuan, Yue Huang, John K. Meissen, Si Mou, Meina Liang, Anton I. Rosenbaum
Publikováno v: BioDrugs. 36:181-196
In recent years, an increase in the discovery and development of biotherapeutics employing new modalities, such as bioconjugates or novel routes of delivery, has created bioanalytical challenges. The inherent complexity of conjugated molecular struct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cac9ab76820dbfbbf5dbc2b5b763e7b
https://doi.org/10.1007/s40259-022-00518-w
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2
Akademický článek
Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin.
Autor: Caitlin Campbell, Dmitry Grapov, Oliver Fiehn, Carol J Chandler, Dustin J Burnett, Elaine C Souza, Gretchen A Casazza, Mary B Gustafson, Nancy L Keim, John W Newman, Gary R Hunter, Jose R Fernandez, W Timothy Garvey, Mary-Ellen Harper, Charles L Hoppel, John K Meissen, Kohei Take, Sean H Adams
Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84260 (2014)
Novel plasma metabolite patterns reflective of improved metabolic health (insulin sensitivity, fitness, reduced body weight) were identified before and after a 14-17 wk weight loss and exercise intervention in sedentary, obese insulin-resistant women
Externí odkaz: https://doaj.org/article/80c7f2c4320f4ab99efac6da7e194303
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3
Akademický článek
Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism.
Autor: John K Meissen, Benjamin T K Yuen, Tobias Kind, John W Riggs, Dinesh K Barupal, Paul S Knoepfler, Oliver Fiehn
Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46770 (2012)
Induced pluripotent stem cells are different from embryonic stem cells as shown by epigenetic and genomics analyses. Depending on cell types and culture conditions, such genetic alterations can lead to different metabolic phenotypes which may impact
Externí odkaz: https://doaj.org/article/dfa564c47dfb414391e572ea7f5cf4a1
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4
Akademický článek
Comparative effects of fructose and glucose on lipogenic gene expression and intermediary metabolism in HepG2 liver cells.
Autor: Kristin M Hirahatake, John K Meissen, Oliver Fiehn, Sean H Adams
Publikováno v: PLoS ONE, Vol 6, Iss 11, p e26583 (2011)
Consumption of large amounts of fructose or sucrose increases lipogenesis and circulating triglycerides in humans. Although the underlying molecular mechanisms responsible for this effect are not completely understood, it is possible that as reported
Externí odkaz: https://doaj.org/article/4688a1b7845b438d957f150d9372cb44
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5
Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics
Autor: Atsushi Ogiwara, John K. Meissen, Tobias Kind, Yuxuan Zheng, Hiroshi Tsugawa, Kohei Takeuchi, Megan R. Showalter, Oliver Fiehn, Matthew Mueller, Gert Wohlgemuth, Zijuan Lai, Sajjan S. Mehta, Masanori Arita, Peter A. Beal
Publikováno v: Nature methods
Novel metabolites distinct from canonical pathways can be identified through the integration of three cheminformatics tools: BinVestigate, which queries the BinBase gas chromatography-mass spectrometry (GC-MS) metabolome database to match unknowns wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c724c5b49bee09fe7c844111f526d671
https://doi.org/10.1038/nmeth.4512
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6
ChREBP regulates fructose-induced glucose production independently of insulin signaling
Autor: Michelle Lai, Hye Lim Noh, Jason K. Kim, Jennifer X. Wang, Misung Kim, Sunia A. Trauger, Hee Joon Kang, John K. Meissen, Alan J. Fowler, Ludivine Doridot, Matthew Blatnik, Sarah A. Krawczyk, Mark A. Herman
Publikováno v: Journal of Clinical Investigation. 126:4372-4386
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant. Specifically, insulin fails to suppress glucose production, yet successfully stimulates de novo li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbab287c1f2625e77f90cb97183497e
https://doi.org/10.1172/jci81993
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7
The Iceman's Last Meal Consisted of Fat, Wild Meat, and Cereals
Autor: Paul Gostner, Mine Palazoglu, Philip Doble, Lars Engstrand, Matthew D. Teasdale, Eduard Egarter-Vigl, Mark J. Sartain, Peter Malfertheiner, John K. Meissen, Ben Krause-Kyora, Thomas Rattei, Sandra Lösch, Oliver Fiehn, Giovanna Cipollini, Andre Franke, Michael R. Hoopmann, Hyun Joo An, Amaury Cazenave-Gassiot, Robert W. Stark, Philipp Rausch, John F. Baines, Frank Maixner, Albert Zink, Almut Nebel, Andreas Keller, Marco Samadelli, Niall O’Sullivan, Dmitrij Turaev, Gea Guerriero, Andreas Putzer, Daniel G. Bradley, Rudolf Grimm, Umberto Tecchiati, Robert L. Moritz, Markus R. Wenk, Ulrike Kusebauch, Alice Paladin, David P. Bishop, Valeria Mattiangeli, Marek Janko, Klaus Oeggl, Bum Jin Kim
Publikováno v: Maixner, Frank; Turaev, Dmitrij; Cazenave-Gassiot, Amaury; Janko, Marek; Krause-Kyora, Ben; Hoopmann, Michael R; Kusebauch, Ulrike; Sartain, Mark; Guerriero, Gea; O'Sullivan, Niall; Teasdale, Matthew; Cipollini, Giovanna; Paladin, Alice; Mattiangeli, Valeria; Samadelli, Marco; Tecchiati, Umberto; Putzer, Andreas; Palazoglu, Mine; Meissen, John; Lösch, Sandra; ... (2018). The Iceman's Last Meal Consisted of Fat, Wild Meat, and Cereals. Current biology, 28(14), 2348-2355.e9. Elsevier 10.1016/j.cub.2018.05.067
Current Biology
Summary The history of humankind is marked by the constant adoption of new dietary habits affecting human physiology, metabolism, and even the development of nutrition-related disorders. Despite clear archaeological evidence for the shift from hunter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb3e319ae4891d9230412fcd0e675c7
https://boris.unibe.ch/119011/1/1-s2.0-S0960982218307036-main.pdf
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8
Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures
Autor: John K. Meissen, Sean H. Adams, Oliver Fiehn, Kristin M. Hirahatake
Publikováno v: Metabolomics : Official journal of the Metabolomic Society, vol 11, iss 3
High fructose consumption has been implicated with deleterious effects on human health, including hyperlipidemia elicited through de novo lipogenesis. However, more global effects of fructose on cellular metabolism have not been elucidated. In order
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efe3dc5c0d2aa9026c924c9bf8857d2
https://doi.org/10.1007/s11306-014-0729-8
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9
Plants Utilize a Highly Conserved System for Repair of NADH and NADPH Hydrates
Autor: Oliver Fiehn, Robert T. Mullen, John K. Meissen, Andrew D. Hanson, Lynn G.L. Richardson, Thomas D. Niehaus, Satinder K. Gidda, Mona Elbadawi-Sidhu
Publikováno v: Plant Physiology. 165:52-61
NADH and NADPH undergo spontaneous and enzymatic reactions that produce R and S forms of NAD(P)H hydrates [NAD(P)HX], which are not electron donors and inhibit various dehydrogenases. In bacteria, yeast (Saccharomyces cerevisiae), and mammals, these
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12a6e7d8fd947c8501d6e533b8d0a8ac
https://doi.org/10.1104/pp.114.236539
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