Zobrazeno 1 - 10
of 129
pro vyhledávání: '"John K MacDonald"'
Autor:
Brian G Feagan, Vipul Jairath, Claire E Parker, Christopher Ma, Siddharth Singh, John K MacDonald, Joshua Chang, Alexa Zayadi, Robert Edge, Blue Neustifter, Guowei Zhong
Publikováno v:
BMJ Open, Vol 13, Iss 12 (2023)
Objectives External control arms (ECAs) provide useful comparisons in clinical trials when randomised control arms are limited or not feasible. We conducted a systematic review to summarise applications of ECAs in trials of immune-mediated inflammato
Externí odkaz:
https://doaj.org/article/2fb6c4875b4541eaba967cfd101aff51
Autor:
Brian G Feagan, Vipul Jairath, Reetesh K Pai, Rish K Pai, Amitabh Srivastava, Christopher Ma, Christophe Rosty, David F Schaeffer, Roger M Feakins, Gregory Y Lauwers, Jonathan Krell, Richard Kirsch, Leonardo Guizzetti, John K MacDonald, Won-Tak Choi, Stefanie C McFarlane, Joanna C. Walsh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Immune checkpoint inhibitor-associated colitis (ICIC) affects approximately 15% of cancer patients treated with immunotherapy. Although histological evaluation is potentially valuable for both the diagnosis of ICIC and evaluation of disease activity,
Externí odkaz:
https://doaj.org/article/68c745c8e80e44898d2db6645e7a63b2
Autor:
Patrick Hamilton, Katherine Buhler, John K. MacDonald, Gilaad G. Kaplan, Cynthia H. Seow, Cathy Lu, Kerri L. Novak, Christopher N. Andrews, Siddharth Singh, Vipul Jairath, Remo Panaccione, Christopher Ma
Publikováno v:
Alimentary Pharmacology & Therapeutics. 57:837-850
Autor:
Tanmay Sharma, Christopher Ma, Rocio Sedano, Jurij Hanzel, Cassandra McDonald, Malcolm Hogan, Gursimran S Kochhar, Neeraj Narula, Laurent Peyrin-Biroulet, Silvio Danese, John K MacDonald, Vipul Jairath
Publikováno v:
Journal of Crohn's and Colitis. 17:644-658
Background and Aims Perianal fistulizing disease is a common complication of Crohn’s disease [CD], for which new therapies are urgently needed. To assist the design of clinical trials for novel therapeutics, we conducted a systematic review and met
Autor:
Theshani A De Silva, Lotus Alphonsus, Christopher Ma, Malcolm Hogan, Rocio Sedano, Neeraj Narula, Silvio Danese, Laurent Peyrin-Biroulet, John K MacDonald, Siddharth Singh, Vipul Jairath
Publikováno v:
Journal of Crohn's and Colitis. 17:123-136
Background and Aims Treatment options for proctitis are limited. To assist trial design for novel therapeutics, we conducted a systematic review and meta-analysis of proctitis randomized controlled trials [RCTs] to quantify placebo rates and identify
Autor:
Lotus Alphonsus, Theshani A. De Silva, Christopher Ma, John K. MacDonald, Jurij Hanzel, Melanie Beaton, Talat Bessissow, Maia Kayal, Rocio Sedano, Siddharth Singh, Vipul Jairath
Publikováno v:
Alimentary Pharmacology & Therapeutics.
Autor:
William J. Sandborn, Geert R. D'Haens, Vipul Jairath, Eileen Crowley, John K MacDonald, Ahmed Almradi, Brian G. Feagan, Malcolm Hogan, Christopher Ma, Guangyong Zou, Rocio Sedano, Siddharth Singh, Jurij Hanzel, Claire E Parker
Publikováno v:
Journal of Crohn's & colitis, 16(5), 717-736. Elsevier
Background Precision in estimating placebo rates is important for clinical trial design. Aim To quantify placebo rates across relevant endpoints in Crohn’s disease [CD] trials and identify the factors influencing these rates in a contemporary meta-
Autor:
Pavine Lefevre, Bryan Linggi, Tran M Nguyen, John K MacDonald, Niels Vande Casteele, Yinghong Wang, Brian G. Feagan, Vipul Jairath, Christopher Ma
Publikováno v:
Digestive Diseases and Sciences. 67:1128-1155
Patients treated with immune checkpoint inhibitors (ICIs) may develop ICI-associated enterocolitis, for which there is no approved treatment. We aimed to systematically review the efficacy and safety of medical interventions for the prevention and tr
Autor:
David W. Chang, Peter C. Neligan, Jaume Masia, Dung Nguyen, Joseph Dayan, John K MacDonald, Babak Mehrara, Arin K. Greene
Publikováno v:
Plastic & Reconstructive Surgery. 147:975-993
Background The goal of this consensus conference, sponsored by the American Association of Plastic Surgeons, was to perform a systematic review and meta-analysis of controlled trials to examine both the benefits and risks of surgical treatment and su
Autor:
Nghia H. Nguyen, Virginia Solitano, Sudheer K. Vuyyuru, John K. MacDonald, Silje W. Syversen, Kristin Kaasen Jørgensen, Eileen Crowley, Christopher Ma, Vipul Jairath, Siddharth Singh
Publikováno v:
Gastroenterology. 163(4)
Proactive therapeutic drug monitoring (TDM) has been proposed to improve outcomes in patients with inflammatory bowel disease (IBD) treated with tumor necrosis factor (TNF)α antagonists. We conducted a systematic review and meta-analysis of randomiz