Zobrazeno 1 - 6
of 6
pro vyhledávání: '"John K Ly"'
Autor:
Bruno Marchand, Nicolas A. Margot, Matthias Götte, Kirsten L. White, Ruth Wang, Michael D. Miller, Martin J. Mcdermott, John K Ly
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:2911-2919
The ATP-dependent phosphorolytic excision of nucleoside analogue reverse transcriptase inhibitors can diminish their inhibitory effects on human immunodeficiency virus replication. Previous studies have shown that excision can occur only when the rev
Autor:
Kirsten L. White, John K Ly, Holly L MacArthur, Michael D. Miller, S. Swaminathan, Nicolas A. Margot, Martin McDermott, James M. Chen, Joy Y. Feng, Adrian S. Ray
Publikováno v:
Antiviral Therapy. 11:155-163
The HIV-1 nucleoside reverse transcriptase inhibitors (NRTIs) tenofovir (TFV), abacavir, didanosine and stavudine can select for K65R, whereas zidovudine (AZT) and stavudine can select for thymidine analogue mutations (TAMs) in HIV-1 reverse transcri
Autor:
Martina Pavelko, James M. Chen, Kirsten L. White, John K Ly, S. Swaminathan, Ruth Wang, Martin McDermott, Adrian S. Ray, Nicolas A. Margot, Michael D. Miller
Publikováno v:
AIDS. 19:1751-1760
Objective: To determine the mechanisms of resistance of K65R mutant reverse transcriptase (RT) to the currently approved nucleoside and nucleotide RT inhibitors (NRTI). Methods: Susceptibilities of K65R mutant HIV-1 to NRTI were determined in cell cu
Autor:
Evguenia S. Svarovskaia, Joy Y. Feng, Derrick D. Goodman, Florence Myrick, Michael D. Miller, John K Ly, Katyna Borroto-Esoda, Kirsten L. White
Publikováno v:
Retrovirology, Vol 6, Iss 1, p 44 (2009)
Retrovirology
Retrovirology
Background Tenofovir disoproxil fumarate (TDF), emtricitabine (FTC), and efavirenz (EFV) are the three components of the once-daily, single tablet regimen (Atripla) for treatment of HIV-1 infection. Previous cell culture studies have demonstrated tha
Autor:
Joy Y. Feng, Nilima Kutty, Katyna Borroto-Esoda, Florence Myrick, Nicolas A. Margot, John K Ly, Evguenia S. Svarovskaia, Ruth Wang, Derrick D. Goodman, Kirsten L. White, Michael D. Miller
Publikováno v:
Journal of acquired immune deficiency syndromes (1999). 48(4)
Background: The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase can be selected by abacavir, didanosine, tenofovir, and stavudine in vivo resulting in reduced susceptibility to these drugs and decreased viral replication ca
Autor:
John K Ly, Kirsten L. White, Holly L MacArthur, Magdeleine Hung, Nicolas A. Margot, Michael D. Miller
Publikováno v:
Antiviral chemistrychemotherapy. 18(6)
The HIV-1 reverse transcriptase (RT) resistance mutations K65R and M184V occur individually and in combination, and can contribute to decreased treatment responses in patients. In order to understand how these mutations interact with one another to c