Zobrazeno 1 - 7
of 7
pro vyhledávání: '"John K L, Wong"'
Autor:
John K. L. Wong, Lena Jassowicz, Christel Herold-Mende, Martina Seiffert, Jan-Philipp Mallm, Peter Lichter, Marc Zapatka
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-6 (2023)
Abstract Background Here we present scSNPdemux, a sample demultiplexing pipeline for single-cell RNA sequencing data using natural genetic variations in humans. The pipeline requires alignment files from Cell Ranger (10× Genomics), a population SNP
Externí odkaz:
https://doaj.org/article/f552b0897e864f92bec52c1fbb48ac58
Autor:
John K. L. Wong, Christian Aichmüller, Markus Schulze, Mario Hlevnjak, Shaymaa Elgaafary, Peter Lichter, Marc Zapatka
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
In cancer, associations between mutational signatures and driver mutations have been proposed but not fully explored. Here, the authors develop sigDriver to find associations between mutational signatures and mutation hotspots in order to predict cod
Externí odkaz:
https://doaj.org/article/10fbc2005901429d9626f59668cfc6e4
Autor:
Natalia Voronina, John K. L. Wong, Daniel Hübschmann, Mario Hlevnjak, Sebastian Uhrig, Christoph E. Heilig, Peter Horak, Simon Kreutzfeldt, Andreas Mock, Albrecht Stenzinger, Barbara Hutter, Martina Fröhlich, Benedikt Brors, Arne Jahn, Barbara Klink, Laura Gieldon, Lina Sieverling, Lars Feuerbach, Priya Chudasama, Katja Beck, Matthias Kroiss, Christoph Heining, Lino Möhrmann, Andrea Fischer, Evelin Schröck, Hanno Glimm, Marc Zapatka, Peter Lichter, Stefan Fröhling, Aurélie Ernst
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The shattering of chromosomes is a dramatic early event in tumourigenesis and is termed chromothripsis. Here, the authors examine chromothripsis across 28 tumour types and show that 49% of cancers exhibit features of chromothripsis.
Externí odkaz:
https://doaj.org/article/bfa7b0c2c5f44dfead7de201eaa3b1b2
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Autor:
Manasi Ratnaparkhe, John K. L. Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T. W. Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M. Downing, Stefan M. Pfister, Marc Zapatka, Peter J. McKinnon, Frederick W. Alt, Peter Lichter, Aurélie Ernst
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chromothripsis and chromoanasynthesis lead to locally clustered rearrangements affecting one or a few chromosomes, but their impact on cancer development and progression is unclear. Here the authors analyse the role of DNA repair factors in brain tum
Externí odkaz:
https://doaj.org/article/8c14a72fa08b47349febd37357e6a636
Autor:
Raneem Habib, Heidemarie Neitzel, Aurelie Ernst, John K. L. Wong, Bozenna Goryluk-Kozakiewicz, Antje Gerlach, Ilja Demuth, Karl Sperling, Krystyna Chrzanowska
Publikováno v:
Molecular Cytogenetics, Vol 11, Iss 1, Pp 1-9 (2018)
Abstract Background Nijmegen breakage syndrome is an autosomal recessive disorder characterized by microcephaly, immunodeficiency, hypersensitivity to X-irradiation, and a high predisposition to cancer. Nibrin, the product of the NBN gene, is part of
Externí odkaz:
https://doaj.org/article/ea6b73b7893847ec9d22ae687d41b9a8
Autor:
Umar Khalid, Milena Simovic, Linda A. Hammann, Murat Iskar, John K. L. Wong, Rithu Kumar, Manfred Jugold, Martin Sill, Michiel Bolkestein, Thorsten Kolb, Michaela Hergt, Frauke Devens, Jonas Ecker, Marcel Kool, Till Milde, Frank Westermann, Axel Benner, Joe Lewis, Sascha Dietrich, Stefan M. Pfister, Peter Lichter, Marc Zapatka, Aurélie Ernst
Publikováno v:
International Journal of Cancer. 151:590-606
Chromothripsis is a form of genomic instability characterized by the occurrence of tens to hundreds of clustered DNA double-strand breaks in a one-off catastrophic event. Rearrangements associated with chromothripsis are detectable in numerous tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee7f5a04cbd64cc8efa38e06aaf21df
https://doi.org/10.1002/ijc.34027
https://doi.org/10.1002/ijc.34027
Autor:
Bola S, Hanna, Laura, Llaó-Cid, Murat, Iskar, Philipp M, Roessner, Lara C, Klett, John K L, Wong, Yashna, Paul, Nikolaos, Ioannou, Selcen, Öztürk, Norman, Mack, Verena, Kalter, Dolors, Colomer, Elías, Campo, Johannes, Bloehdorn, Stephan, Stilgenbauer, Sascha, Dietrich, Manfred, Schmidt, Richard, Gabriel, Karsten, Rippe, Markus, Feuerer, Alan G, Ramsay, Peter, Lichter, Marc, Zapatka, Martina, Seiffert
Publikováno v:
Immunity. 54(12)
T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses identified a subset o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7d083f208fa077095390dc49708bdbd
https://pubmed.ncbi.nlm.nih.gov/34879221
https://pubmed.ncbi.nlm.nih.gov/34879221