Zobrazeno 1 - 10
of 72
pro vyhledávání: '"John K, Fallon"'
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 2, Pp 279-291 (2023)
Abstract Ibrutinib is an orally administered Bruton's tyrosine kinase inhibitor approved for the treatment of B‐cell malignancies, including chronic lymphocytic leukemia. Ibrutinib is metabolized primarily via oxidation by cytochrome P450 (CYP) 3A4
Externí odkaz:
https://doaj.org/article/4935ea4c73e445beb021d7eeebf7c603
Autor:
Chitra Saran, Dong Fu, Henry Ho, Abigail Klein, John K. Fallon, Paavo Honkakoski, Kim L. R. Brouwer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Hepatic cell lines serve as economical and reproducible alternatives for primary human hepatocytes. However, the utility of hepatic cell lines to examine bile acid homeostasis and cholestatic toxicity is limited due to abnormal expression an
Externí odkaz:
https://doaj.org/article/2e928e8ce9f046e3be3c75900b5eddad
Autor:
Muluneh M. Fashe, Taryn A. Miner, John K. Fallon, Amanda P. Schauer, Craig Sykes, Philip C. Smith, Craig R. Lee
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Pregnancy increases the clearance of CYP3A4 substrate drugs and pregnancy-related hormones (PRHs) induce hepatic CYP3A4 expression and metabolism. However, it remains unclear to what extent the magnitude of PRH-evoked changes in hepatic
Externí odkaz:
https://doaj.org/article/5bf5aea07c3d46e3afd836d8b7b04fe3
Autor:
Matthew J. Haney, Yuling Zhao, John K. Fallon, Yue Wang, Samuel M. Li, Emily E. Lentz, Dorothy Erie, Philip C. Smith, Elena V. Batrakova
Publikováno v:
Advanced NanoBiomed Research, Vol 3, Iss 6, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/803452927ed3406f968e269e0891c3b9
Autor:
Olumide B. Gbolahan, Bert H. O’Neil, Autumn J. McRee, Hanna K. Sanoff, John K. Fallon, Philip C. Smith, Anastasia Ivanova, Dominic T. Moore, Julie Dumond, Gary N. Asher
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 5, Pp 1304-1315 (2022)
Abstract Curcumin inhibits UDP‐glucuronyltransferases, a primary metabolic pathway for cancer chemotherapeutic agents like irinotecan. Concurrent administration of both agents may exacerbate irinotecan toxicity. We conducted this phase I study to d
Externí odkaz:
https://doaj.org/article/fa1504397a544f8b85cc3b7d1c010124
Autor:
Muluneh M. Fashe, John K. Fallon, Taryn A. Miner, Jacqueline B. Tiley, Philip C. Smith, Craig R. Lee
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Pregnancy alters the disposition and exposure to multiple drugs indicated for pregnancy-related complications. Previous in vitro studies have shown that pregnancy-related hormones (PRHs) alter the expression and function of certain cytochrome P450s (
Externí odkaz:
https://doaj.org/article/1e6c5b0acbba40869e4315e3c168bd86
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-15 (2019)
Abstract Background The intestinal epithelium is a major site of drug metabolism in the human body, possessing enterocytes that house brush border enzymes and phase I and II drug metabolizing enzymes (DMEs). The enterocytes are supported by a porous
Externí odkaz:
https://doaj.org/article/adc56a430eae49b5bbd4a36bff87d61b
Autor:
Matthew J. Haney, Yuling Zhao, John K. Fallon, Yue Wang, Samuel M. Li, Emily E. Lentz, Dorothy Erie, Philip C. Smith, Elena V. Batrakova
Publikováno v:
Advanced NanoBiomed Research, Vol 1, Iss 12, Pp n/a-n/a (2021)
Extracellular vesicles (EVs) represent a next generation drug delivery system that combines nanoparticle size with extraordinary ability to cross biological barriers, reduced immunogenicity, and low offsite toxicity profiles. A successful application
Externí odkaz:
https://doaj.org/article/ee15ab4b4ebf4cac89bb0ef3ebb803ec
Autor:
Jennifer E. Speer, Dulan B. Gunasekara, Yuli Wang, John K. Fallon, Peter J. Attayek, Philip C. Smith, Christopher E. Sims, Nancy L. Allbritton
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-15 (2019)
Abstract Background The luminal surface of the small intestine is composed of a monolayer of cells overlying a lamina propria comprised of extracellular matrix (ECM) proteins. The ECM provides a porous substrate critical for nutrient exchange and cel
Externí odkaz:
https://doaj.org/article/311d021565a34122b0d8a07d36fae0df
Autor:
Yuling Zhao, Matthew J. Haney, John K. Fallon, Myosotys Rodriguez, Carson J. Swain, Camryn J. Arzt, Philip C. Smith, Matthew Shane Loop, Emily B. Harrison, Nazira El-Hage, Elena V. Batrakova
Publikováno v:
Cells, Vol 11, Iss 12, p 1933 (2022)
Extracellular vesicles (EVs) are cell-derived nanoparticles that facilitate transport of proteins, lipids, and genetic material, playing important roles in intracellular communication. They have remarkable potential as non-toxic and non-immunogenic n
Externí odkaz:
https://doaj.org/article/f43b0e0e1cde45cda912a22132c1f305