Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John Joslin"'
Autor:
Hao Chen, Frederick J. King, Bin Zhou, Yu Wang, Carter J. Canedy, Joel Hayashi, Yang Zhong, Max W. Chang, Lars Pache, Julian L. Wong, Yong Jia, John Joslin, Tao Jiang, Christopher Benner, Sumit K. Chanda, Yingyao Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Many machine learning applications in bioinformatics currently rely on matching gene identities when analyzing input gene signatures and fail to take advantage of preexisting knowledge about gene functions. To further enable comparative anal
Externí odkaz:
https://doaj.org/article/3b4f238e44764f15bb18667e531420c4
Autor:
Shefali Chauhan, Andrew D. Woods, Narendra Bharathy, Xiaolei Lian, Cora A. Ricker, Amy Mantz, William J. Zuercher, Lisa H. Price, Michael J. Morton, Eric Durrant, Stéphane Y. Corbel, Srinath C. Sampath, Srihari C. Sampath, John Joslin, Charles Keller
Publikováno v:
Biochemical and Biophysical Research Communications. 667:138-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5495e2cf41b464d773d5fa7ec301e49
https://doi.org/10.1016/j.bbrc.2023.04.114
https://doi.org/10.1016/j.bbrc.2023.04.114
Autor:
Elena Menichelli, Bianca J. Lam, Yu Wang, Vivian S. Wang, Jennifer Shaffer, Katrina F. Tjhung, Badry Bursulaya, Truc Ngoc Nguyen, Todd Vo, Phillip B Alper, Christopher S McAllister, David H. Jones, Glen Spraggon, Pierre-Yves Michellys, John Joslin, Gerald F. Joyce, Jeff Rogers
Publikováno v:
Proceedings of the National Academy of Sciences. 119
There is growing interest in therapeutic intervention that targets disease-relevant RNAs using small molecules. While there have been some successes in RNA-targeted small-molecule discovery, a deeper understanding of structure–activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b63539b3423ca34c26d9030ee5bf0b
https://doi.org/10.1073/pnas.2213117119
https://doi.org/10.1073/pnas.2213117119
Autor:
John Joslin, Jerome Giovannoni, John I. Manchester, Eugen Lounkine, Douglas S. Auld, Nikolas Fechner, Philipp Krastel, Caroline Engeloch, Jutta Blank, Manuel Schwarze, Ansgar Schuffenhauer, Nikolaus Stiefl, Johanna M. Jansen, Nadine Schneider, Lauren G. Monovich, Simona Cotesta, Michael Shultz, Samuel Hintermann, Daniel K. Baeschlin, Christoph Gaul, Anna Paola Pelliccioli
Publikováno v:
Journal of medicinal chemistry. 63(23)
This article summarizes the evolution of the screening deck at the Novartis Institutes for BioMedical Research (NIBR). Historically, the screening deck was an assembly of all available compounds. In 2015, we designed a first deck to facilitate access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe7d489f3ff53766acb91c3cacff935
https://pubmed.ncbi.nlm.nih.gov/33140646
https://pubmed.ncbi.nlm.nih.gov/33140646
A Fully Automated High-Throughput Flow Cytometry Screening System Enabling Phenotypic Drug Discovery
Autor:
Orzala Sharif, Miranda King, Christopher M. Shaw, Steven B Cohen, Catherine Garcia, Scott A. Lesley, Jennifer L. Harris, Bin Zhou, Michael Conner, Ed Ainscow, James Gilligan, Paul Anderson, Christopher Trussell, John Joslin, Jennifer Snead, Robert Dunn, Janice Hampton, Dan Sipes, Tommy Nguyen, Anthony E. Boitano, Mike Cooke, Yingyao Zhou, Shumei Jiang, James Kevin Mainquist, John W. Fathman
Publikováno v:
Slas Discovery
The goal of high-throughput screening is to enable screening of compound libraries in an automated manner to identify quality starting points for optimization. This often involves screening a large diversity of compounds in an assay that preserves a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ded4952e507374b9b1515c47ca97ab
http://europepmc.org/articles/PMC6055113
http://europepmc.org/articles/PMC6055113