Výsledky vyhledávání - "John Jg Tesmer"

Akademický článek

Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

Autor: Sandeep K Ravala, Sendi Rafael Adame-Garcia, Sheng Li, Chun-Liang Chen, Michael A Cianfrocco, J Silvio Gutkind, Jennifer N Cash, John JG Tesmer

Publikováno v: eLife, Vol 12 (2024)

PIP3-dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a guanine-nucleotide exchange factor (GEF) for Rac. The enzyme is synergistically activated by PI

Externí odkaz: https://doaj.org/article/6899a600b5494b9685972f9468cccefe

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Akademický článek

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

Autor: Kelly A Manthei, Shyh-Ming Yang, Bolormaa Baljinnyam, Louise Chang, Alisa Glukhova, Wenmin Yuan, Lita A Freeman, David J Maloney, Anna Schwendeman, Alan T Remaley, Ajit Jadhav, John JG Tesmer

Publikováno v: eLife, Vol 7 (2018)

Lecithin:cholesterol acyltransferase (LCAT) and LCAT-activating compounds are being investigated as treatments for coronary heart disease (CHD) and familial LCAT deficiency (FLD). Herein we report the crystal structure of human LCAT in complex with a

Externí odkaz: https://doaj.org/article/e39ef85950bb4a8db30d83b97e4ee9fa

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Akademický článek

C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

Autor: Anthony W Azevedo, Thuy Doan, Hormoz Moaven, Iza Sokal, Faiza Baameur, Sergey A Vishnivetskiy, Kristoff T Homan, John JG Tesmer, Vsevolod V Gurevich, Jeannie Chen, Fred Rieke

Publikováno v: eLife, Vol 4 (2015)

Rod photoreceptors generate measurable responses to single-photon activation of individual molecules of the G protein-coupled receptor (GPCR), rhodopsin. Timely rhodopsin desensitization depends on phosphorylation and arrestin binding, which quenches

Externí odkaz: https://doaj.org/article/4edccd85553d48d8a0ead6c6fbec1158

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