Zobrazeno 1 - 10
of 12
pro vyhledávání: '"John Jascur"'
Autor:
Sourav Bandyopadhyay, Andrei Goga, Frank McCormick, Kevan M. Shokat, Nevan J. Krogan, Stuart L. Schreiber, Alykhan F. Shamji, Paul A. Clemons, Jaime Cheah, Antonio Sorrentino, Mike Shales, John Jascur, Jeff Johnson, Rebecca S. Levin, John D. Gordan, Taha Rakhshandehroo, Christina Yau, Dai Horiuchi, Alexandra Corella, Alicia Y. Zhou, Maria M. Martins
Supplementary Table S2. Drugs and their concentrations used in the isogenic drug screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ceecba2ea240f6046b9bdcfe401f9a2
https://doi.org/10.1158/2159-8290.22529895.v1
https://doi.org/10.1158/2159-8290.22529895.v1
Autor:
Sourav Bandyopadhyay, Andrei Goga, Frank McCormick, Kevan M. Shokat, Nevan J. Krogan, Stuart L. Schreiber, Alykhan F. Shamji, Paul A. Clemons, Jaime Cheah, Antonio Sorrentino, Mike Shales, John Jascur, Jeff Johnson, Rebecca S. Levin, John D. Gordan, Taha Rakhshandehroo, Christina Yau, Dai Horiuchi, Alexandra Corella, Alicia Y. Zhou, Maria M. Martins
Supplementary Table S3. Chemical-genetic interaction scores derived in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2db196e428f192a5dd51a6eaec06f5b
https://doi.org/10.1158/2159-8290.22529892
https://doi.org/10.1158/2159-8290.22529892
Autor:
Sourav Bandyopadhyay, Andrei Goga, Frank McCormick, Kevan M. Shokat, Nevan J. Krogan, Stuart L. Schreiber, Alykhan F. Shamji, Paul A. Clemons, Jaime Cheah, Antonio Sorrentino, Mike Shales, John Jascur, Jeff Johnson, Rebecca S. Levin, John D. Gordan, Taha Rakhshandehroo, Christina Yau, Dai Horiuchi, Alexandra Corella, Alicia Y. Zhou, Maria M. Martins
Supplementary Figure 1. Distribution of gene alterations in Breast TCGA and verification of expression of MCF10A cells. Supplementary Figure 2. Analysis of the MCF10A drug screen. Supplementary Figure 3. Significance of overlap between interactions f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02486064772f8aab6c1c615417b162ea
https://doi.org/10.1158/2159-8290.22529901
https://doi.org/10.1158/2159-8290.22529901
Autor:
Sourav Bandyopadhyay, Andrei Goga, Frank McCormick, Kevan M. Shokat, Nevan J. Krogan, Stuart L. Schreiber, Alykhan F. Shamji, Paul A. Clemons, Jaime Cheah, Antonio Sorrentino, Mike Shales, John Jascur, Jeff Johnson, Rebecca S. Levin, John D. Gordan, Taha Rakhshandehroo, Christina Yau, Dai Horiuchi, Alexandra Corella, Alicia Y. Zhou, Maria M. Martins
Supplementary Table S1. List of constructs used to generate stable cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc598840092892683b4cf826d866a89
https://doi.org/10.1158/2159-8290.22529898.v1
https://doi.org/10.1158/2159-8290.22529898.v1
A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer
Autor:
Sourav Bandyopadhyay, Franziska Haderk, Emilie Gross, Khyati N. Shah, Victor Olivas, D. Ciznadija, Trever G. Bivona, Ido Sloma, Vincent B. Masto, Scott L. Weinrich, Xin Zhao, Nevan J. Krogan, Hsien-Ming Hu, John Jascur, Shigeki Nanjo, Swati Kaushik, Jeffery R. Johnson, Gwendolyn M. Jang
SUMMARYSignaling networks balance the activities of many physically interacting proteins and perturbations to this network influence downstream signaling, potentially leading to oncogenic states. Using affinity purification-mass spectrometry we defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc83a7b774349d894102eb9c332058a2
https://doi.org/10.1101/2020.07.02.185173
https://doi.org/10.1101/2020.07.02.185173
Autor:
Xin Zhao, Hsien-Ming Hu, Erik Verschueren, John Jascur, Khyati N. Shah, Nevan J. Krogan, Jeffrey R. Johnson, Sourav Bandyopadhyay, John Von Dollen, Swati Kaushik, Gwendolyn M. Jang
Publikováno v:
Cancer Research. 78:3297-3297
Characterization of the genomic landscapes of cancer patients has provided valuable insights into the key oncogenic drivers and revolutionized the concept of precision treatment of patients. However, a key limitation is that targetable alterations ar
Autor:
Stuart L. Schreiber, John D. Gordan, Frank McCormick, Alykhan F. Shamji, Christina Yau, Kevan M. Shokat, Dai Horiuchi, Andrei Goga, Sourav Bandyopadhyay, Maria M. Martins, Michael Shales, Jeffrey R. Johnson, Paul A. Clemons, Jaime Cheah, Nevan J. Krogan, Alicia Y. Zhou, Taha Rakshandehroo, John Jascur, Rebecca S. Levin, Alexandra Corella, Antonio Sorrentino
Publikováno v:
Cancer discovery, vol 5, iss 2
There is an urgent need in oncology to link molecular aberrations in tumors with therapeutics that can be administered in a personalized fashion. One approach identifies synthetic–lethal genetic interactions or dependencies that cancer cells acquir
Autor:
Alicia Y. Zhou, Stuart L. Schreiber, Kevan M. Shokat, John Jascur, Rebecca S. Levin, Andrei Goga, Dai Horiuchi, John D. Gordan, Alexandra Corella, Jeffrey R. Johnson, Nevan J. Krogan, Antonio Sorrentino, Christina Yau, Maria M. Martins, Alykhan F. Shamji, Frank McCormick, Michael Shales, Taha Rakshandehroo, Sourav Bandyopadhyay, Jaime Cheah, Paul Clemens, Susan Samson
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 25:C88-C88
Background: Collaborative team science provides a starting point for comprehensive change, and advocates have a unique and important role developing and engaging in transdisciplinary collaboratives that focus on new questions and new possibilities to
Autor:
Maria M. Martins, Alicia Y. Zhou, Alexandra Corella, Dai Horiuchi, Christina Yau, Taha Rakshandehroo, John D. Gordan, Rebecca S. Levin, Jeff Johnson, John Jascur, Mike Shales, Antonio Sorrentino, Jaime Cheah, Paul A. Clemons, Alykhan Shamji, Stuart Schreiber, Nevan J. Krogan, Kevan M. Shokat, Frank McCormick, Daniel Nomura, Sourav Bandyopadhyay, Andrei Goga
Publikováno v:
Cancer Research. 75:PR07-PR07
There is an urgent need in oncology to link molecular aberrations in tumors with altered cellular behaviors, such as metabolic derangements, and to identify novel therapeutics for cancer treatment. We have sought to identify synthetic-lethal genetic
Autor:
Maria M. Martins, Alicia Y. Zhou, Alexandra Corella, Dai Horiuchi, Christina Yau, Taha Rakshandehroo, John D. Gordan, Rebecca S. Levin, Jeff Johnson, John Jascur, Mike Shales, Antonio Sorrentino, Jaime Cheah, Paul A. Clemons, Alykhan Shamji, Stuart Schreiber, Nevan J. Krogan, Kevan M. Shokat, Frank McCormick, Daniel Nomura, Sourav Bandyopadhyay, Andrei Goga
Publikováno v:
Cancer Research. 75:PR15-PR15
There is an urgent need in oncology to link molecular aberrations in tumors with altered cellular behaviors, such as metabolic derangements, and to identify novel therapeutics for cancer treatment. We have sought to identify synthetic-lethal genetic