Zobrazeno 1 - 10
of 26
pro vyhledávání: '"John Janetzko"'
Autor:
Jonathan Pacheco, Karina A. Peña, Sofya Savransky, Alexandre Gidon, Gerald R. V. Hammond, John Janetzko, Jean-Pierre Vilardaga
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The assembly of a peptide ligand, its receptor, and β-arrestin (βarr) into a ternary complex within the cell membrane is a crucial aspect of G protein-coupled receptor (GPCR) signaling. We explore this assembly by attaching fluorescent moi
Externí odkaz:
https://doaj.org/article/1ce330aebdeb49edb5e7abc9774e7bea
The second Transatlantic Early Career Investigator (ECI) G Protein-Coupled Receptor (GPCR) Symposium was an online scientific meeting geared at young GPCR investigators, with the primary goal of expanding opportunities for sharing research and networ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b035a657178fc3acdebfc28cbf3d36
http://hdl.handle.net/10261/310349
http://hdl.handle.net/10261/310349
Publikováno v:
Biochemistry
Glycosylation of nuclear and cytoplasmic proteins is an essential post-translational modification in mammals. O-GlcNAc transferase (OGT), the sole enzyme responsible for this modification, glycosylates over a thousand unique nuclear and cytoplasmic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac2b6c7ed77826409ceeba0aa6c7297
https://doi.org/10.1021/acs.biochem.0c00981
https://doi.org/10.1021/acs.biochem.0c00981
Autor:
John Janetzko, Ryoji Kise, Benjamin Barsi‐Rhyne, Dirk H. Siepe, Franziska M. Heydenreich, Matthieu Masureel, Kouki Kawakami, K. C. Garcia, Mark Zastrow, Asuka Inoue, Brian K. Kobilka
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61af36971992f108e0a5ac3ee1f54248
https://doi.org/10.1096/fasebj.2022.36.s1.r6320
https://doi.org/10.1096/fasebj.2022.36.s1.r6320
Autor:
John Janetzko, Ryoji Kise, Benjamin Barsi-Rhyne, Dirk H. Siepe, Franziska M. Heydenreich, Kouki Kawakami, Matthieu Masureel, Shoji Maeda, K. Christopher Garcia, Mark von Zastrow, Asuka Inoue, Brian K. Kobilka
Publikováno v:
Cell
Binding of arrestin to phosphorylated G protein-coupled receptors (GPCRs) is crucial for modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins, while others interact only transiently; this difference affects GPCR sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0080dd89b74624622aa3a8a342956a
Autor:
John Janetzko, Asuka Inoue, Yuqi Shi, Jonathan C. Deutsch, Korak Kumar Ray, Matthieu Masureel, Ruben L. Gonzalez, Rosa Viner, Brian K. Kobilka, Rabindra Shivnaraine
Publikováno v:
Biophysical Journal. 122:49a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::390c85f63e30221f53c6ff79efb132bd
https://doi.org/10.1016/j.bpj.2022.11.476
https://doi.org/10.1016/j.bpj.2022.11.476
Autor:
Kouki Kawakami, John Janetzko, Brian K. Kobilka, M. Von Zastrow, Kenan Christopher Garcia, Franziska M. Heydenreich, B. Barsi-Rhyne, D. H. Siepe, Ryoji Kise, Matthieu Masureel, Asuka Inoue
Summary Arrestins recognize activated and phosphorylated G protein-coupled receptors (GPCRs) and are responsible for promoting acute desensitization of receptors as well as their endocytosis. As phosphatidylinositols have been shown to bind to compon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eade9e69a3a353421d4fe34bac26fac
https://doi.org/10.1101/2021.10.09.463790
https://doi.org/10.1101/2021.10.09.463790
Autor:
Damien Y. Duveau, Craig J. Thomas, Harri M. Itkonen, Steven P. Gygi, John Janetzko, Sara E. S. Martin, Joao A. Paulo, Lisa Törk, Zhi-Wei Tan, Michael B. Lazarus, Suzanne Walker, Frederick A. Moss, Paul L. Boutz
Publikováno v:
Journal of the American Chemical Society. 140:13542-13545
Reversible glycosylation of nuclear and cytoplasmic proteins is an important regulatory mechanism across metazoans. One enzyme, O-linked N-acetylglucosamine transferase (OGT), is responsible for all nucleocytoplasmic glycosylation and there is a well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39d4686a46c731ca67bcf39ff48cc44
https://doi.org/10.1021/jacs.8b07328
https://doi.org/10.1021/jacs.8b07328
Autor:
John Janetzko, Suzanne Walker
Publikováno v:
Journal of the American Chemical Society. 139:3332-3335
O-linked β-N-acetylglucosamine transferase (OGT) is an essential human enzyme that glycosylates numerous nuclear and cytoplasmic proteins on serine and threonine. It also cleaves Host cell factor 1 (HCF-1) by a mechanism in which the first step invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb23a0259493567ef97d3022db5350d
https://doi.org/10.1021/jacs.6b12866
https://doi.org/10.1021/jacs.6b12866
Autor:
Khanh Nguyen, Asuka Inoue, Brian K. Kobilka, Michael J. Robertson, Georgios Skiniotis, John Janetzko, Qianhui Qu, Weijiao Huang, Matthieu Masureel, Jeffrey S. Glenn, Hideaki E. Kato
Publikováno v:
Nature
Arrestin proteins bind to active, phosphorylated G-protein-coupled receptors (GPCRs), thereby preventing G-protein coupling, triggering receptor internalization and affecting various downstream signalling pathways1,2. Although there is a wealth of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0999aff803a4e57bc80010c676ff765e
https://pubmed.ncbi.nlm.nih.gov/31945771
https://pubmed.ncbi.nlm.nih.gov/31945771