Zobrazeno 1 - 10
of 587
pro vyhledávání: '"John J. Voorhees"'
Autor:
Feiyang Ma, Olesya Plazyo, Allison C. Billi, Lam C. Tsoi, Xianying Xing, Rachael Wasikowski, Mehrnaz Gharaee-Kermani, Grace Hile, Yanyun Jiang, Paul W. Harms, Enze Xing, Joseph Kirma, Jingyue Xi, Jer-En Hsu, Mrinal K. Sarkar, Yutein Chung, Jeremy Di Domizio, Michel Gilliet, Nicole L. Ward, Emanual Maverakis, Eynav Klechevsky, John J. Voorhees, James T. Elder, Jun Hee Lee, J. Michelle Kahlenberg, Matteo Pellegrini, Robert L. Modlin, Johann E. Gudjonsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A a
Externí odkaz:
https://doaj.org/article/7d7e27df0a374d5eb3a7f42f1d8c5e5f
Autor:
Mrinal K. Sarkar, Ranjitha Uppala, Chang Zeng, Allison C. Billi, Lam C. Tsoi, Austin Kidder, Xianying Xing, Bethany E. Perez White, Shuai Shao, Olesya Plazyo, Sirisha Sirobhushanam, Enze Xing, Yanyun Jiang, Katherine A. Gallagher, John J. Voorhees, J. Michelle Kahlenberg, Johann E. Gudjonsson
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
CRISPR/Cas9 has been proposed as a treatment for genetically inherited skin disorders. Here we report that CRISPR transfection activates STING-dependent antiviral responses in keratinocytes, resulting in heightened endogenous interferon (IFN) respons
Externí odkaz:
https://doaj.org/article/2e6f622a55a149e8bca5194f792c60eb
Autor:
Kaveri Karhade, MD, Megan Lawlor, MD, Heather Chubb, MS, Timothy R.B. Johnson, MD, John J. Voorhees, MD, Frank Wang, MD
Publikováno v:
International Journal of Women's Dermatology, Vol 7, Iss 5, Pp 685-691 (2021)
Background: The impact of striae gravidarum (SG), or stretch marks of pregnancy, on quality of life (QoL) is unclear. Objective: The purpose of this study was to investigate how SG affect QoL in pregnant women. Methods: In this cross-sectional survey
Externí odkaz:
https://doaj.org/article/2cb24ea24e984bebaf5bb012229ef555
Autor:
Philip E. Stuart, Lam C. Tsoi, Rajan P. Nair, Manju Ghosh, Madhulika Kabra, Pakeeza A. Shaiq, Ghazala K. Raja, Raheel Qamar, B.K. Thelma, Matthew T. Patrick, Anita Parihar, Sonam Singh, Sujay Khandpur, Uma Kumar, Michael Wittig, Frauke Degenhardt, Trilokraj Tejasvi, John J. Voorhees, Stephan Weidinger, Andre Franke, Goncalo R. Abecasis, Vinod K. Sharma, James T. Elder
Publikováno v:
HGG Advances, Vol 3, Iss 1, Pp 100069- (2022)
Summary: Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genome-wide association study (GWAS) of psoriasis in South Asians (SAS), consisting of 2,590 cases and 1,720 controls. Comparison with our
Externí odkaz:
https://doaj.org/article/5428a1ebeaa24b259fb5e47d9912fd38
Autor:
Johann E. Gudjonsson, Lam C. Tsoi, Feiyang Ma, Allison C. Billi, K.R. van Straalen, A.R.J.V. Vossen, H.H. van der Zee, Paul W. Harms, Rachael Wasikowski, Christine M. Yee, Syed M. Rizvi, Xianying Xing, Enze Xing, Olesya Plazyo, Chang Zeng, Matthew T. Patrick, Margaret M. Lowe, Richard E. Burney, Jeffrey H. Kozlow, Jill R. Cherry-Bukowiec, Yanyun Jiang, Joseph Kirma, Stephan Weidinger, Kelly C. Cushing, Michael D. Rosenblum, Celine Berthier, Amanda S. MacLeod, John J. Voorhees, Fei Wen, J. Michelle Kahlenberg, Emanual Maverakis, Robert L. Modlin, Errol P. Prens
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic app
Externí odkaz:
https://doaj.org/article/6a9a009215b84bf6a72948e92d18fa18
Autor:
Matthew T. Patrick, Philip E. Stuart, Kalpana Raja, Johann E. Gudjonsson, Trilokraj Tejasvi, Jingjing Yang, Vinod Chandran, Sayantan Das, Kristina Callis-Duffin, Eva Ellinghaus, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Hyun M. Kang, Gerald G. Krueger, Henry W. Lim, Proton Rahman, Cheryl F. Rosen, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, John J. Voorhees, Gonçalo R. Abecasis, Dafna D. Gladman, Rajan P. Nair, James T. Elder, Lam C. Tsoi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA) and early diagnosis is crucial for the management of PsA. Here, Patrick et al. develop a computational pipeline involving statistical and machine-learning methods that can asse
Externí odkaz:
https://doaj.org/article/f67954f1b8fa41a1be488a5ddddc158b
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background Transcription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact of YAP and TAZ levels
Externí odkaz:
https://doaj.org/article/03b96a102fcb417a9025b3c6a5dc6d3a
Autor:
Nehal N. Mehta, Heather L. Teague, William R. Swindell, Yvonne Baumer, Nicole L. Ward, Xianying Xing, Brooke Baugous, Andrew Johnston, Aditya A. Joshi, Joanna Silverman, Drew H. Barnes, Liza Wolterink, Rajan P. Nair, Philip E. Stuart, Martin Playford, John J. Voorhees, Mrinal K. Sarkar, James T. Elder, Katherine Gallagher, Santhi K. Ganesh, Johann E. Gudjonsson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Chronic inflammation is a critical component of atherogenesis, however, reliable human translational models aimed at characterizing these mechanisms are lacking. Psoriasis, a chronic inflammatory skin disease associated with increased suscep
Externí odkaz:
https://doaj.org/article/2fc891577ed8496cab73a2b9d95b1c7b
Autor:
Lam C. Tsoi, Philip E. Stuart, Chao Tian, Johann E. Gudjonsson, Sayantan Das, Matthew Zawistowski, Eva Ellinghaus, Jonathan N. Barker, Vinod Chandran, Nick Dand, Kristina Callis Duffin, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Dafna D. Gladman, Per Hoffmann, Külli Kingo, Sulev Kõks, Gerald G. Krueger, Henry W. Lim, Andres Metspalu, Ulrich Mrowietz, Sören Mucha, Proton Rahman, Andre Reis, Trilokraj Tejasvi, Richard Trembath, John J. Voorhees, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, Nicholas Eriksson, Hyun M. Kang, David A. Hinds, Rajan P. Nair, Gonçalo R. Abecasis, James T Elder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals.
Externí odkaz:
https://doaj.org/article/f7c9d14db1d44c6a865877ade1d17933
Autor:
Matthew T. Patrick, Philip E. Stuart, Kalpana Raja, Sunyi Chi, Zhi He, John J. Voorhees, Trilokraj Tejasvi, Johann E. Gudjonsson, J. Michelle Kahlenberg, Vinod Chandran, Proton Rahman, Dafna D. Gladman, Rajan P. Nair, James T. Elder, Lam C. Tsoi
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
We recently conducted a large association analysis to compare the genetic profiles between patients with psoriatic arthritis (PsA) and cutaneous-only psoriasis (PsC). Despite including over 7,000 genotyped patients, only the MHC achieved genome-wide
Externí odkaz:
https://doaj.org/article/80b4cbc08a6c4994af9ada4abecb3beb