Zobrazeno 1 - 10
of 195
pro vyhledávání: '"John J. Tentler"'
Autor:
John J. Tentler, Julie Lang, Anna Capasso, Deog Joong Kim, Ely Benaim, Young B. Lee, Andrew Eisen, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, Todd M. Pitts, Roberta Pelanda, S. Gail Eckhardt, Jennifer R. Diamond
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited systemic treatment options. RX-5902 is a novel anti-cancer agent that inhibits phosphorylated-p68 and thus attenuates nuclear β-catenin sign
Externí odkaz:
https://doaj.org/article/1dcda43bbcb945d6ae883320daa5d648
Autor:
Nzali V. Campbell, David A. Weitzenkamp, Ian L. Campbell, Ronald F. Schmidt, Chindo Hicks, Michael J. Morgan, David C. Irwin, John J. Tentler
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-30 (2018)
Abstract Background Large-scale “omics” datasets have not been leveraged and integrated with functional analyses to discover potential drivers of cardiomyopathy. This study addresses the knowledge gap. Methods We coupled RNA sequence (RNA-Seq) va
Externí odkaz:
https://doaj.org/article/b219e30ec3af47d4b81c42cfe582ac3b
Autor:
Sarah J. Hartman, Stacey M. Bagby, Betelehem W. Yacob, Dennis M. Simmons, Morgan MacBeth, Christopher H. Lieu, S. Lindsey Davis, Alexis D. Leal, John J. Tentler, Jennifer R. Diamond, S. Gail Eckhardt, Wells A. Messersmith, Todd M. Pitts
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with high incidences of p53 mutations. AZD1775 (adavosertib, previously MK-1775) is a small molecule WEE1 inhibitor that abrogates the G2M checkpoint and can potentially synergize with
Externí odkaz:
https://doaj.org/article/3fd57b698eda4a68a4b0e9a0920a5bdc
Autor:
Jennifer R. Diamond, S. G. Eckhardt, Todd M. Pitts, Adrie van Bokhoven, Dara Aisner, Daniel L. Gustafson, Anna Capasso, Sharon Sams, Peter Kabos, Kathryn Zolman, Tiffany Colvin, Anthony D. Elias, Anna M. Storniolo, Bryan P. Schneider, Dexiang Gao, John J. Tentler, Virginia F. Borges, Kathy D. Miller
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-10 (2018)
Abstract Background Triple-negative breast cancer (TNBC) remains an aggressive breast cancer subtype with limited treatment options. ENMD-2076 is a small-molecule inhibitor of Aurora and angiogenic kinases with proapoptotic and antiproliferative acti
Externí odkaz:
https://doaj.org/article/b8114fdcf25045a88513879cfaf4520b
Autor:
Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt, Todd M. Pitts
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types including colorectal cancer (CRC) and portends a poor prognosis. TAK
Externí odkaz:
https://doaj.org/article/d4dd779ae0964c9eb1a995ae2b3952c9
Autor:
Todd M. Pitts, Dennis M. Simmons, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, John J. Tentler, Diana Cittelly, D. Ryan Ormond, Wells A. Messersmith, S. Gail Eckhardt, Jennifer R. Diamond
Publikováno v:
Cancers, Vol 12, Iss 3, p 719 (2020)
Triple-negative breast cancer (TNBC) is an aggressive subtype defined by lack of hormone receptor expression and non-amplified HER2. Adavosertib (AZD1775) is a potent, small-molecule, ATP-competitive inhibitor of the Wee1 kinase that potentiates the
Externí odkaz:
https://doaj.org/article/98303b9316db4c7cb0e1e6133ffcdc79
Autor:
Anastasia A. Ionkina, John J. Tentler, Jihye Kim, Anna Capasso, Todd M. Pitts, Karen A. Ryall, Rebekah R. Howison, Peter Kabos, Carol A. Sartorius, Aik Choon Tan, S. Gail Eckhardt, Jennifer R. Diamond
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
PurposeTriple-negative breast cancer (TNBC) is a subtype associated with poor prognosis and for which there are limited therapeutic options. The purpose of this study was to evaluate the efficacy of ENMD-2076 in p53-mutated TNBC patient-derived xenog
Externí odkaz:
https://doaj.org/article/45eb6612dff34704ad5bff2c901deb5e
Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models
Autor:
S. Lindsey eDavis, Kelli M. Robertson, Todd M. Pitts, John J. Tentler, Erica L. Bradshaw-Pierce, Peter J. Klauck, Stacey M. Bagby, Stephanie L. Hyatt, Heather M. Selby, Anna eSpreafico, Jeffrey A Ecsedy, John J. Arcaroli, Wells A. Messersmith, Aik Choon eTan, S. Gail eEckhardt
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Aurora A kinase and MEK inhibitors induce different, and potentially complementary, effects on the cell cycle of malignant cells, suggesting a rational basis for utilizing these agents in combination. In this work, the combination of an Aurora A kina
Externí odkaz:
https://doaj.org/article/5f6654c44590401dbc1d91d387e8147f
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 6 (2014)
Triple-negative breast cancer (TNBC) represents a challenge clinically due to a lack of response to hormonal and HER2-targeted agents coupled with an aggressive disease course. As the biology of this breast cancer subtype is better understood, it is
Externí odkaz:
https://doaj.org/article/af49300d03794ea4bfddd9bec9cbd6f6
Autor:
William A. Robinson, Robert C. Doebele, Theresa Medina, Rene Gonzalez, Aik-Choon Tan, Matthew J. Rioth, Yiqun G. Shellman, John J. Tentler, Edna Chow-Maneval, Pratik Multani, Carol Amato, Allison Applegate, Keith Wells, Todd M. Pitts, Anh Le, Jennifer D. Hintzsche, Jason Christiansen, Danielle Murphy, Stacey M. Bagby, Jacqueline A. Turner, Judson Bemis, Kasey L. Couts
Non-specific immunoblot bands in MB 1692 and MB 1374
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4686ba4268cdf469c3029bca5d3d3e32
https://doi.org/10.1158/1535-7163.22509220
https://doi.org/10.1158/1535-7163.22509220