Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John J. Tegeler"'
Autor:
R. Richard L. Hamer, Lawrence L. Martin, John J. Tegeler, Ellen S. Kurtz, Penelope A. Przekop, Mary Ellen Elliott, Luther Hellyer, Steven C. Bailey, Richard C. Allen, Helsley Grover C, John H. White, Brian S. Freed
Publikováno v:
Journal of Medicinal Chemistry. 39:246-252
Hydroxylamine and hydroxamic acid derivatives of a known nonsteroidal antiinflammatory dibenzoxepine series display both cyclooxygenase (CO) and 5-lipoxygenase (5-LO) inhibitory properties. Many of these new dual CO/5-LO inhibitors also exhibit poten
Autor:
Rauckman Barbara S, Brian S. Freed, John J. Tegeler, Gregory H. Merriman, Marie Ortega-Nanos, R. Richard L. Hamer, Luther Hellyer, Ellen S. Kurtz, Steven C. Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2477-2482
Novel aryl-fused sphingolipids, in which aryl-/heteroaryl-moieties were incorporated into the allylic 4,5,6-positions of sphingosine, were prepared and found to possess good in vitro PKC inhibitory activity. (3-(1-Dodecynyl)phenyl)- and (4- and (5-(1
Autor:
R. Richard L. Hamer, Luther Hellyer, John J. Tegeler, Marie Ortega-Nanos, Penelope A. Przekop, Rauckman Barbara S, Brian S. Freed, Steven C. Bailey, Gregory H. Merriman, Ellen S. Kurtz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2483-2488
Recently we identified three promising topically active antiinflammatory agents ( 2 , 3 , and 4 ) from a series of racemic aryl-sphingolipids that inhibit protein kinase C (PKC). We now wish to report the enantioselective synthesis of the aforementio
Autor:
Penelope A. Przekop, Gregory H. Merriman, Steven C. Bailey, Luther Hellyer, Brian S. Freed, Marie Ortega-Nanos, R. Richard L. Hamer, John J. Tegeler, Ellen S. Kurtz, Rauckman Barbara S
Publikováno v:
ChemInform. 27
Recently we identified three promising topically active antiinflammatory agents ( 2 , 3 , and 4 ) from a series of racemic aryl-sphingolipids that inhibit protein kinase C (PKC). We now wish to report the enantioselective synthesis of the aforementio
Autor:
Steven C. Bailey, Luther Hellyer, Penelope A. Przekop, Lawrence L. Martin, John H. White, Mary Ellen Elliott, Brian S. Freed, Helsley Grover C, R. Richard L. Hamer, Ellen S. Kurtz, Richard C. Allen, John J. Tegeler
Publikováno v:
ChemInform. 27
Hydroxylamine and hydroxamic acid derivatives of a known nonsteroidal antiinflammatory dibenzoxepine series display both cyclooxygenase (CO) and 5-lipoxygenase (5-LO) inhibitory properties. Many of these new dual CO/5-LO inhibitors also exhibit poten
Autor:
Eugene J. Trybulski, S. Asrof Ali, Joseph J. Tufariello, George Mullen, Shing Chun Wong, John J. Tegeler
Publikováno v:
Journal of the American Chemical Society. 101:2435-2442
Autor:
Joseph J. Tufariello, John J. Tegeler
Publikováno v:
Tetrahedron Letters. 17:4037-4040
Publikováno v:
Journal of Heterocyclic Chemistry. 20:867-870
Several (dihydrobenzoxathiinyloxy)acetic acids have been prepared as potential antihypertensive agents. The dihydrobenzoxathiin ring system was constructed via an intramolecular alkoxide displacement reaction.
Publikováno v:
Tetrahedron Letters. 19:1733-1736
Autor:
John J. Tegeler, Craig J. Diamond
Publikováno v:
Journal of Heterocyclic Chemistry. 24:697-699
Intrermolecular cyclization of 1,3-dipolar aroylnitrile oxides to malononitrile provided a viable approach to a variety of novel (3-aroyl-1,2,4-oxadiazol-5-yl)acetic acid derivatives.