Zobrazeno 1 - 10
of 206
pro vyhledávání: '"John J. Skehel"'
Autor:
Antoni G. Wrobel, Donald J. Benton, Chloë Roustan, Annabel Borg, Saira Hussain, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding
Externí odkaz:
https://doaj.org/article/b4dd4e7327c04cb0a388bbe45794406e
Autor:
Antoni G. Wrobel, Donald J. Benton, Pengqi Xu, Lesley J. Calder, Annabel Borg, Chloë Roustan, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to hum
Externí odkaz:
https://doaj.org/article/e6fc3e78a8f74f72b0f0a1e0880a8bb4
Autor:
Antoni G. Wrobel, Donald J. Benton, Saira Hussain, Ruth Harvey, Stephen R. Martin, Chloë Roustan, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
Here, the authors characterise the binding and neutralisation properties of CR3022, a neutralising Ab isolated from a convalescent SARS patient, against SARS-CoV-2 spike trimers and show using Cryo-EM the disruption of SARS-CoV-2 spike by CR3022 Fab.
Externí odkaz:
https://doaj.org/article/d4d4b2a7e1194f45b301bc4c82ffd83f
Autor:
Xiaoli Xiong, Steven J. Gamblin, Jie Zhang, Sébastien G. Vachieri, Stephen R. Martin, John J. Skehel
Publikováno v:
Cold Spring Harbor perspectives in medicine. 11(10)
Hemagglutinins (HAs) are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence, virus at
Autor:
Eva Garcia-Moro, Jie Zhang, Lesley J. Calder, Nick R. Brown, Steven J. Gamblin, John J. Skehel, Peter B. Rosenthal
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The subunits of the influenza hemagglutinin (HA) trimer are synthesized as single-chain precursors (HA0s) that are proteolytically cleaved into the disulfide-linked polypeptides HA1 and HA2. Cleavage is required for activation of membrane fusion at l
Autor:
D.J. Benton, Chloe Roustan, John J. Skehel, Stephen R. Martin, Steven J. Gamblin, A.G. Wrobel, Peter B. Rosenthal, Pengqi Xu
Publikováno v:
Nature
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by virus binding to the ACE2 cell-surface receptors1-4, followed by fusion of the virus and cell membranes to release the virus genome into the cell. Both recept
Autor:
John J. Skehel, Stephen R. Martin, A.G. Wrobel, Peter B. Rosenthal, Chloe Roustan, Saira Hussain, Annabel Borg, Steve Gamblin, D.J. Benton
Recently emerged variants of SARS-CoV-2 contain in their surface spike glycoproteins multiple substitutions associated with increased transmission and resistance to neutralising antibodies. We have examined the structure and receptor binding properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741046cad28d5321ce3b490fbc6f2c74
Autor:
John J. Skehel, Annabel Borg, D.J. Benton, Pengqi Xu, Chloe Roustan, A.G. Wrobel, Peter B. Rosenthal, Stephen R. Martin, S.J. Gamblin
Publikováno v:
Proceedings of the National Academy of Sciences. 118
The authors note that on page 3, left column, first paragraph, line 5, “K848” should instead appear as “K854.” The online version has been corrected.
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003843 (2014)
The homeostatic mechanisms that regulate the maintenance of immunological memory to the multiple pathogen encounters over time are unknown. We found that a single malaria episode caused significant dysregulation of pre-established Influenza A virus-s
Externí odkaz:
https://doaj.org/article/5f40007204624acfbed26a80524bfd9b
Autor:
Chloe Roustan, D.J. Benton, Lesley J. Calder, Pengqi Xu, Steven J. Gamblin, A.G. Wrobel, John J. Skehel, Peter B. Rosenthal, Stephen R. Martin, Annabel Borg
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We a