Zobrazeno 1 - 10
of 47
pro vyhledávání: '"John J. Schwartz"'
Publikováno v:
Journal of Biological Chemistry. 274:24417-24424
To determine the role played by syndecan-4 cytoplasmic domain in the mediation of basic fibroblast growth factor (bFGF) signaling, immortalized human cells (ECV) were used to generate cell lines expressing constructs encoding full-length sequences fo
Autor:
Nicholas W. Shworak, Robert D. Rosenberg, Linda M.S. Fritze, Jian Liu, Lijuan Zhang, Pierre Sinaÿ, John J. Schwartz
Publikováno v:
Journal of Biological Chemistry. 274:5185-5192
The 3-O-sulfation of glucosamine residues is an important modification during the biosynthesis of heparan sulfate (HS). Our previous studies have led us to purify and molecularly clone the heparan sulfate d-glucosaminyl 3-O-sulfotransferase (3-OST-1)
Autor:
Jian Liu, Linda M.S. Fritze, John J. Schwartz, Lijuan Zhang, Joseph M. Miller, Nicholas W. Shworak, Robert D. Rosenberg
Publikováno v:
Journal of Biological Chemistry. 273:27998-28003
Retinoic acid (RA) and dibutyryl cAMP plus theophilline (CT) trigger F9 cells to differentiate into parietal endoderm. The differentiation induces a 9-fold increase in total heparan sulfate (HStotal) biosynthesis and a 170-fold increase in anticoagul
Autor:
John J. Schwartz, Jian Liu, Lijuan Zhang, Delphine Logeart, Linda M.S. Fritze, Nicholas W. Shworak, Robert D. Rosenberg
Publikováno v:
Journal of Biological Chemistry. 272:28008-28019
The cellular rate of anticoagulant heparan sulfate proteoglycan (HSPGact) generation is determined by the level of a kinetically limiting microsomal activity, HSact conversion activity, which is predominantly composed of the long sought heparan sulfa
Publikováno v:
Gene. 146:57-65
An 11,955-bp region of the Borrelia burgdorferi chromosome containing all the genes encoding ribosomal RNA (rRNA) has been sequenced. The region contains a single gene encoding 16S rRNA and two genes encoding the 23S and 5S rRNAs. The sizes of the 16
Publikováno v:
FEMS Microbiology Letters. 112:211-216
Translation initiation factor IF3 plays a crucial role in initiation of protein synthesis in bacteria. In order to elucidate the IF3 structural elements required for these functions, the evolutionary conservation of IF3 and its gene, infC, was invest
Autor:
A Gazumyan, G L Campbell, Ira Schwartz, E Zimmermann, P Weissensee, G. P. Wormser, John J. Schwartz, Susan Bittker, Denise Cooper, Neil S. Goldberg, Charles S. Pavia
Publikováno v:
Journal of Clinical Microbiology. 30:3082-3088
Current laboratory diagnosis of Lyme disease relies on tests for the detection of antibodies to Borrelia burgdorferi, the etiologic agent of the disease. These tests are often unreliable because of a lack of sensitivity and specificity and test-to-te
Publikováno v:
Journal of Bacteriology. 174:3757-3765
Lyme disease is the most common vector-borne disease in the United States. The causative agent is the spirochete Borrelia burgdorferi. The copy number and organization of the genes encoding the rRNAs of this organism were determined. There is a singl
Autor:
Shuguang Zhang, Aaron T. Santos, Kimberly Hamad-Schifferli, Joseph M. Jacobson, John J. Schwartz
Publikováno v:
Nature. 415(6868)
Increasingly detailed structural and dynamic studies are highlighting the precision with which biomolecules execute often complex tasks at the molecular scale. The efficiency and versatility of these processes have inspired many attempts to mimic or
Autor:
Ge Wei, Xiaomei Bai, John J. Schwartz, Jeffrey D. Esko, Lijuan Zhang, Roger Lawrence, Robert D. Rosenberg
Publikováno v:
The Journal of biological chemistry. 276(31)
To understand how 2-O-sulfation of uronic acid residues influences the biosynthesis of anticoagulant heparan sulfate, the cDNA encoding glucosaminyl 3-O-sulfotransferase-1 (3-OST-1) was introduced into wild-type Chinese hamster ovary cells and mutant