Zobrazeno 1 - 10
of 79
pro vyhledávání: '"John J. Rinehart"'
Autor:
Markos Leggas, Jeffrey A. Moscow, Bryan K. Kee, Philip A. DeSimone, Brent J. Shelton, Scott Z. Fields, John R. Eckardt, Eleftheria Tsakalozou, John J. Rinehart, Susanne M. Arnold
Purpose: 7-t-Butyldimethylsilyl-10-hydroxycamptothecin (AR-67) is a novel third generation camptothecin selected for development based on the blood stability of its pharmacologically active lactone form and its high potency in preclinical models. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431ecb4232f06be5b02beed885c5d068
https://doi.org/10.1158/1078-0432.c.6519104
https://doi.org/10.1158/1078-0432.c.6519104
Autor:
Markos Leggas, Jeffrey A. Moscow, Bryan K. Kee, Philip A. DeSimone, Brent J. Shelton, Scott Z. Fields, John R. Eckardt, Eleftheria Tsakalozou, John J. Rinehart, Susanne M. Arnold
Supplementary Data from A Phase I Study of 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin in Adult Patients with Refractory or Metastatic Solid Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047b538c96397ae6b4ac775b93d405cf
https://doi.org/10.1158/1078-0432.22442357
https://doi.org/10.1158/1078-0432.22442357
Autor:
John J. Rinehart, Sandra Sellers, Mansoor N. Saleh, Pierre L. Triozzi, Jeffrey Neidhart, Mary J. Waddell, Graeme B. Bolger, Karen O. Allen
Publikováno v:
The Prostate. 65:316-321
BACKGROUND Gonadotropin releasing hormone (GnRH)-DT vaccine elicits antibody that may inhibit prostate cancers indirectly by blocking GnRH induced gonadotropin release, and consequent androgen synthesis, and directly by immune effector and antiprolif
Autor:
Roman Herrera, Judith S. Sebolt-Leopold, Eric Kaldjian, Alex A. Adjei, Peggy Asbury, David Y. Mitchell, Ronald B. Natale, John J. Rinehart, M. B. Meyer, Mary Varterasian, Stephen Gulyas, Oday Hamid, J. Randolph Hecht, David Waterhouse, Patricia Lorusso
Publikováno v:
Journal of Clinical Oncology. 22:4456-4462
Purpose This multicenter, open-label, phase II study was undertaken to assess the antitumor activity and safety of the oral mitogen-activated extracellular signal regulated kinase kinase (MEK) inhibitor, CI-1040, in breast cancer, colon cancer, non-s
Publikováno v:
Cancer Chemotherapy and Pharmacology. 53:459-467
Hematoprotective strategies may offer new approaches to prevent chemotherapy-induced hematotoxicity. The present study was undertaken to investigate the chemoprotective effects of dexamethasone and its optimal dose and the underlying mechanisms.Letha
Publikováno v:
Clinical Cancer Research. 10:1633-1644
Purpose: The present study was undertaken to determine the effects of dexamethasone (DEX) pretreatment on antitumor activity and pharmacokinetics of the cancer chemotherapeutic agents carboplatin and gemcitabine.Experimental Design: Antitumor activit
Autor:
Lisa Keville, Marie Aberle, John J. Rinehart, Gretchen A. Cloud, Jeff Neidhart, Lucio DiNunno, Lucas Wong, Patricia Kinney, Laura Tadlock
Publikováno v:
American Journal of Clinical Oncology. 26:448-458
Based on preclinical studies, the authors undertook a pilot study to determine the hematologic and biologic effects of pretreatment with dexamethasone (Dex) or granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients receiving carboplati
Autor:
S. Ebbinghaus, Adrienne Williams, Eric J. Rubin, Robert S. DiPaola, Greg Winchell, John J. Rinehart, Karen E Wickersham, Ned Adams, Susan Goodwin, Michelle Fontaine, John Nemunaitis, S. Doyle-Lindrud, Deutsch Paul J, Michael Schwartz, Marie Ciardella, Terry Capanna, Siu-Long Yao
Publikováno v:
Journal of Clinical Oncology. 20:1874-1879
PURPOSE: To evaluate safety and pharmacokinetics (PK), and determine the recommended dose for efficacy studies, of L-377202, a novel peptide conjugate of doxorubicin (Dox) that releases the active metabolites leucine-doxorubicin (Leu-Dox) and Dox on
Publikováno v:
Journal of Urology. 159:1379-1383
Purpose: The insulin-like growth factor (IGF) system appears to be important in human prostate cancer biology. Expression of specific IGF binding proteins (IGFBPs) by prostate cancer tissues may modulate IGF cellular actions, and possibly determine b
Autor:
Lisa Keville, John J. Rinehart
Publikováno v:
Cytotechnology. 24:153-159
In examining the effects of corticosteroids on hematopoiesis in vitro, we observed that results were highly dependent on the lot of commercial fetal calf serum (FCS) utilized. We hypothesized that this variability correlated with the picogram (pg) le