Zobrazeno 1 - 10
of 101
pro vyhledávání: '"John J. Reiners"'
Autor:
Cornelis J. Elferink, John J. Reiners
Publikováno v:
BioTechniques, Vol 20, Iss 3, Pp 470-477 (1996)
A quantitative reverse transcription polymerase chain reaction (RT-PCR) assay was developed to amplify a region of the CYP1A1 heterogeneous nuclear RNA (hnRNA) transcript encompassing the first intron-exon boundary. The RT-PCR protocol uses a CYP1A1
Externí odkaz:
https://doaj.org/article/5be6f0229dd349879831a13df0ab21bc
Publikováno v:
Drug Metabolism and Disposition. 44:665-671
CYP1A1 and CYP1A2 are transcriptionally activated in the human normal breast epithelial cell line MCF10A following exposure to 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD). Shifting MCF10A cultures to medium deficient in serum and epidermal growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9b7e38079dce58c46d1767d0f3458c
https://doi.org/10.1124/dmd.115.066274
https://doi.org/10.1124/dmd.115.066274
Autor:
David Kessel, John J. Reiners
Publikováno v:
Photochemistry and Photobiology. 91:931-936
We previously reported that low level lysosomal photodamage enhanced the efficacy of subsequent mitochondrial photodamage, resulting in a substantial promotion of apoptotic cell death. We now extend our analysis of the sequential PDT protocol to incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb9b77bc3f1d07db81875faadd056ed
https://doi.org/10.1111/php.12456
https://doi.org/10.1111/php.12456
Publikováno v:
Autophagy. 12(10)
Accumulating evidence suggests that mitogen-activated protein kinases (MAPKs) regulate macroautophagy/autophagy. However, the involvement of dual-specificity protein phosphatases (DUSPs), endogenous inhibitors for MAPKs, in autophagy remains to be de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68471d6dd4de376dcec5f2efb165ea2b
https://pubmed.ncbi.nlm.nih.gov/27459239
https://pubmed.ncbi.nlm.nih.gov/27459239
Oncogenic Ras proteins are a driving force in a significant set of human cancers and wild-type, unmutated Ras proteins likely contribute to the malignant phenotype of many more. The overall challenge of targeting activated Ras proteins has great prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8cab9f170040384f1cd2e0f426c315
https://europepmc.org/articles/PMC4955559/
https://europepmc.org/articles/PMC4955559/
Autor:
Hongyu You, Linda Weglicki, Amanda J. Wheeler, Alice Grgicak-Mannion, Jason Booza, Lindsay Miller, John J. Reiners, Delbert M. Raymond, Phillip Graniero, Richard Krajenta, Helene J. Krouse, Shannon M. Molaroni, Lawrence D. Lemke, Xiaohong Xu, Lois Lamerato
Publikováno v:
Atmospheric Environment. 46:683-686
Dept. of Civil and Environmental Engineering, University of Windsor, Windsor, Ontario, Canada Dept. of Geology, Wayne State University, 0224 Old Main, 4841 Cass, Detroit, MI 48202, USA Air Health Science Division, Health Canada, Ottawa, Ontario, Cana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65972c40cfd36515dcb81ad3b121ecd7
https://doi.org/10.1016/j.atmosenv.2011.10.010
https://doi.org/10.1016/j.atmosenv.2011.10.010
Autor:
Bonnie F. Sloane, Jonathan W. Wojtkowiak, John J. Reiners, Komal M. Sane, Raymond R. Mattingly, Miriam D. Kleinman
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 337:65-74
Exposure of the human malignant peripheral nerve sheath tumor cell lines STS-26T, ST88-14, and NF90-8 to nanomolar concentrations of both lovastatin and farnesyl transferase inhibitor (FTI)-1 but not to either drug alone induced cell death. ST88-14 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab527b5017fa3db84dd798882183df46
https://doi.org/10.1124/jpet.110.174573
https://doi.org/10.1124/jpet.110.174573
Publikováno v:
Free Radical Biology and Medicine. 50:281-294
Reactive oxygen species (ROS) can induce lysosomal membrane permeabilization (LMP). Photoirradiation of murine hepatoma 1c1c7 cultures preloaded with the photosensitizer NPe6 generates singlet oxygen within acidic organelles, and causes LMP and the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2e4dc62c98880b60d4cc5190ae334c
https://doi.org/10.1016/j.freeradbiomed.2010.11.006
https://doi.org/10.1016/j.freeradbiomed.2010.11.006
Autor:
Linda Weglicki, Lawrence D. Lemke, Richard Krajenta, Xiaohong Xu, Alice Grgicak-Mannion, Delbert M. Raymond, Hongyu You, John J. Reiners, Lindsay Miller, Jason Booza, Shannon M. Molaroni, Lois Lamerato, Amanda J. Wheeler, Helene J. Krouse, Phillip Graniero
Publikováno v:
Atmospheric Environment. 44:1162-1174
As part of a larger research project initiated by the Geospatial Determinants of Health Outcomes Consortium (GeoDHOC), an air quality study was conducted in an international airshed encompassing Detroit, Michigan, USA, and Windsor, Ontario, Canada. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d2aab6964d351c1ba06a71882589f4e
https://doi.org/10.1016/j.atmosenv.2009.12.030
https://doi.org/10.1016/j.atmosenv.2009.12.030
Autor:
John J. Reiners, Farid S. Fouad, Daniel T. LaLonde, Raymond R. Mattingly, Ivory Dean, Richard A. Gibbs, Jonathan W. Wojtkowiak, Komal M. Sane, Michelle Mynderse, Richard F. Borch
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 333:23-33
Prenylation inhibitors have gained increasing attention as potential therapeutics for cancer. Initial work focused on inhibitors of farnesylation, but more recently geranylgeranyl transferase inhibitors (GGTIs) have begun to be evaluated for their po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74301949259e0caa68d67378d6ddf9e0
https://doi.org/10.1124/jpet.109.160192
https://doi.org/10.1124/jpet.109.160192