Zobrazeno 1 - 10
of 78
pro vyhledávání: '"John J. Reho"'
Autor:
Kirthikaa Balapattabi, Yavuz Yavuz, Jingwei Jiang, Guorui Deng, Natalia M. Mathieu, McKenzie L. Ritter, Megan A. Opichka, John J. Reho, John D. McCorvy, Pablo Nakagawa, Lisa L. Morselli, Gary C. Mouradian, Jr., Deniz Atasoy, Huxing Cui, Matthew R. Hodges, Curt D. Sigmund, Justin L. Grobe
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112935- (2023)
Summary: Resting metabolic rate (RMR) adaptation occurs during obesity and is hypothesized to contribute to failed weight management. Angiotensin II (Ang-II) type 1 (AT1A) receptors in Agouti-related peptide (AgRP) neurons contribute to the integrati
Externí odkaz:
https://doaj.org/article/232d89e1a4584d099a23a192408018ec
Autor:
Karen C. Clark, Valerie A. Wagner, Katie L. Holl, John J. Reho, Monika Tutaj, Jennifer R. Smith, Melinda R. Dwinell, Justin L. Grobe, Anne E. Kwitek
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Central obesity is genetically complex, and its exponential increase in the last decades have made it a critical public health issue. The Lyon Hypertensive (LH) rat is a well-characterized hypertensive model that also exhibits spontaneous and profoun
Externí odkaz:
https://doaj.org/article/6cbcb81d5ccc4454ad8acdfa47eaf264
Autor:
Shi Fang, Jing Wu, John J. Reho, Ko-Ting Lu, Daniel T. Brozoski, Gaurav Kumar, Alec M. Werthman, Sebastiao Donato Silva Jr., Patricia C. Muskus Veitia, Kelsey K. Wackman, Angela J. Mathison, Bi Qing Teng, Chien-Wei Lin, Frederick W. Quelle, Curt D. Sigmund
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
Arterial stiffness predicts cardiovascular disease and all-cause mortality, but its treatment remains challenging. Mice treated with angiotensin II (Ang II) develop hypertension, arterial stiffness, vascular dysfunction, and a downregulation of Rho-r
Externí odkaz:
https://doaj.org/article/60eddd64545c4137aff300a2f830a14d
Autor:
John J. Reho, Pablo Nakagawa, Gary C. Mouradian, Connie C. Grobe, Fatima L. Saravia, Colin M. L. Burnett, Anne E. Kwitek, John R. Kirby, Jeffrey L. Segar, Matthew R. Hodges, Curt D. Sigmund, Justin L. Grobe
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Cardiovascular disease represents the leading cause of death in the United States, and metabolic diseases such as obesity represent the primary impediment to improving cardiovascular health. Rodent (mouse and rat) models are widely used to model card
Externí odkaz:
https://doaj.org/article/73056cd0043d4e7d857e5b13667ef72a
Autor:
Jingwei Jiang, John J. Reho, Sajag Bhattarai, Ioana Cherascu, Adam Hedberg-Buenz, Kacie J. Meyer, Fariba Tayyari, Adam J. Rauckhorst, Deng Fu Guo, Donald A. Morgan, Eric B. Taylor, Michael G. Anderson, Arlene V. Drack, Kamal Rahmouni
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101308- (2021)
Objectives: Endothelial cells that line the entire vascular system play a pivotal role in the control of various physiological processes, including metabolism. Additionally, endothelial dysfunction is associated with many pathological conditions, inc
Externí odkaz:
https://doaj.org/article/331797b4150b47959372685c8f61ab8c
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 9 (2019)
Background The mechanistic target of rapamycin complex 1 (mTORC1) is an important intracellular energy sensor that regulates gene expression and protein synthesis through its downstream signaling components, the S6‐kinase and the ribosomal S6 prote
Externí odkaz:
https://doaj.org/article/8423b15624ca45a58f1f742174440afa
Autor:
McKenzie L, Ritter, Guorui, Deng, John J, Reho, Yue, Deng, Sarah A, Sapouckey, Megan A, Opichka, Kirthikaa, Balapattabi, Kelsey K, Wackman, Daniel T, Brozoski, Ko-Ting, Lu, William J, Paradee, Katherine N, Gibson-Corley, Huxing, Cui, Pablo, Nakagawa, Lisa L, Morselli, Curt D, Sigmund, Justin L, Grobe
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 79(12)
RGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. Single nucleotide polymorphisms in theTo study cell-specific functions of RGS2, a novel gene-targeted mouse harboring a conditional allele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::827128aade704ab416b60eeea61e3c12
https://pubmed.ncbi.nlm.nih.gov/36259376
https://pubmed.ncbi.nlm.nih.gov/36259376
Autor:
Vanessa Oliveira, John J. Reho, Kirthikaa Balapattabi, McKenzie L. Ritter, Natalia M. Mathieu, Megan A. Opichka, Ko-Ting Lu, Connie C. Grobe, Sebastião D. Silva, Kelsey K. Wackman, Pablo Nakagawa, Jeffrey L. Segar, Curt D. Sigmund, Justin L. Grobe
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 323(4)
The renin-angiotensin system (RAS) within the brain is implicated in the control of fluid and electrolyte balance, autonomic functions, blood pressure, and energy expenditure. Mouse models are increasingly used to explore these mechanisms; however, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef6d9a59b150d36370d8b9c9e49659e
https://pubmed.ncbi.nlm.nih.gov/35816717
https://pubmed.ncbi.nlm.nih.gov/35816717
Autor:
Natalia M. Mathieu, Pablo Nakagawa, Connie C. Grobe, John J. Reho, Daniel T. Brozoski, Ko-Ting Lu, Kelsey K. Wackman, McKenzie L. Ritter, Jeffrey L. Segar, Justin L. Grobe, Curt D. Sigmund
Publikováno v:
Hypertension. 79:2480-2492
Background: GPCRs (G protein–coupled receptors) are implicated in blood pressure (BP) and fluid intake regulation. There is a developing concept that these effects are mediated by both canonical G protein signaling and noncanonical β-arrestin medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3908a1b216e1d81536e3beb97c3ad3
https://doi.org/10.1161/hypertensionaha.122.19863
https://doi.org/10.1161/hypertensionaha.122.19863
Autor:
Chetan N. Patil, McKenzie L. Ritter, Kelsey K. Wackman, Vanessa Oliveira, Kirthikaa Balapattabi, Connie C. Grobe, Daniel T. Brozoski, John J. Reho, Pablo Nakagawa, Gary C. Mouradian, Alison J. Kriegel, Anne E. Kwitek, Matthew R. Hodges, Jeffrey L. Segar, Curt D. Sigmund, Justin L. Grobe
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Hypertension characterized by low circulating renin activity accounts for roughly 25%–30% of primary hypertension in humans and can be modeled experimentally via deoxycorticosterone acetate (DOCA)-salt treatment. In this model, phenotypes develop i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256011de1c175481d2fb2de87e479109
https://doi.org/10.1152/ajpregu.00017.2022
https://doi.org/10.1152/ajpregu.00017.2022