Zobrazeno 1 - 10
of 28
pro vyhledávání: '"John J. Lehman"'
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 2, Pp 273-281 (2012)
Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a key regulator of energy metabolism and lipid homeostasis in multiple highly oxidative tissues, has been implicated in the metabolic derangements of diabetes and obesity. Ho
Externí odkaz:
https://doaj.org/article/37780714050444e2a6258d57c97a4dde
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 2, Pp 273-281 (2012)
Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a key regulator of energy metabolism and lipid homeostasis in multiple highly oxidative tissues, has been implicated in the metabolic derangements of diabetes and obesity. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d525b2cae4965717bbcc8b8068a057b1
https://doi.org/10.1194/jlr.m020628
https://doi.org/10.1194/jlr.m020628
Autor:
John O. Holloszy, May M. Chen, Dong Ho Han, John J. Lehman, Paul J. Schaeffer, Adam R. Wende, Janice M. Huss, Chad R. Hancock, Glendon J. Parker, Donald A. McClain, Christoph Peter Gerhard Zechner, Daniel P. Kelly
Publikováno v:
Journal of Biological Chemistry. 282:36642-36651
The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) has been identified as an inducible regulator of mitochondrial function. Skeletal muscle PGC-1alpha expression is induced post-exercise.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9fc1f36cf75d8525c947cade3a4c2a
https://doi.org/10.1074/jbc.m707006200
https://doi.org/10.1074/jbc.m707006200
Publikováno v:
Journal of Biological Chemistry. 268:20713-20716
To identify the phospholipase mediating the majority of [Arg8]vasopressin (AVP)-induced release of arachidonic acid in A-10 smooth muscle cells, we exploited the specificity inherent in the mechanism-based inhibitor, (E)-6-(bromomethylene)tetrahydro-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::958d33274100c120641e4160f3263cdc
https://doi.org/10.1016/s0021-9258(19)36837-1
https://doi.org/10.1016/s0021-9258(19)36837-1
Publikováno v:
Journal of molecular and cellular cardiology. 46(2)
Heart failure is a cause of significant morbidity and mortality in developed nations, and results from a complex interplay between genetic and environmental factors. To discover gene regulatory networks underlying heart failure, we analyzed DNA micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46fff1d3fe7ac9995efc5b5596cfb0b
https://pubmed.ncbi.nlm.nih.gov/19061896
https://pubmed.ncbi.nlm.nih.gov/19061896
Autor:
Wei Yan, Harold F. Sims, David J. Mancuso, John J. Lehman, Kui Yang, Richard W. Gross, Jeffrey E. Saffitz, Xianlin Han, Jingyue Yang, Christopher M. Jenkins, Nandakumar Sambandam, Karen G. Green, Dana R. Abendschein
Publikováno v:
The Journal of biological chemistry. 282(12)
Previously, we identified calcium-independent phospholipase A2gamma (iPLA2gamma) with multiple translation initiation sites and dual mitochondrial and peroxisomal localization motifs. To determine the role of iPLA2gamma in integrating lipid and energ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b552f45e5b4a9ba3ec6458f8bafeaa42
https://pubmed.ncbi.nlm.nih.gov/17213206
https://pubmed.ncbi.nlm.nih.gov/17213206
Autor:
Denis M. Medeiros, Michael Courtois, Laurie K. Russell, Jeffrey E. Saffitz, John Alan McDonald, Attila Kovacs, Carolyn M. Mansfield, Daniel P. Kelly, Maria L. Valencik, John J. Lehman
Publikováno v:
Circulation research. 94(4)
Recent evidence has identified the peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) as a regulator of cardiac energy metabolism and mitochondrial biogenesis. We describe the development of a transgenic system that perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc958d84a191818f907c269711bf8d04
https://pubmed.ncbi.nlm.nih.gov/14726475
https://pubmed.ncbi.nlm.nih.gov/14726475
Autor:
John J, Lehman, Daniel P, Kelly
Publikováno v:
Heart failure reviews. 7(2)
Studies in a variety of mammalian species, including humans, have demonstrated a reduction in fatty acid oxidation (FAO) and increased glucose utilization in pathologic cardiac hypertrophy, consistent with reinduction of the fetal energy metabolic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84bd2b0d2db60e7b55b6add7bf75094d
https://pubmed.ncbi.nlm.nih.gov/11988641
https://pubmed.ncbi.nlm.nih.gov/11988641
Autor:
Daniel P. Kelly, John J. Lehman
Publikováno v:
Clinical and experimental pharmacologyphysiology. 29(4)
1. The present review focuses on the gene regulatory mechanisms involved in the control of cardiac mitochondrial energy production in the developing heart and following the onset of pathological cardiac hypertrophy. Particular emphasis has been given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcdfc0250e0286a89720f77a6d63594
https://pubmed.ncbi.nlm.nih.gov/11985547
https://pubmed.ncbi.nlm.nih.gov/11985547
Autor:
Brian N, Finck, John J, Lehman, Teresa C, Leone, Michael J, Welch, Michael J, Bennett, Attila, Kovacs, Xianlin, Han, Richard W, Gross, Ray, Kozak, Gary D, Lopaschuk, Daniel P, Kelly
Publikováno v:
The Journal of clinical investigation. 109(1)
Recent evidence has defined an important role for PPARalpha in the transcriptional control of cardiac energy metabolism. To investigate the role of PPARalpha in the genesis of the metabolic and functional derangements of diabetic cardiomyopathy, mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea8a00e04f025ca3dc98488e66c33660
https://pubmed.ncbi.nlm.nih.gov/11781357
https://pubmed.ncbi.nlm.nih.gov/11781357