Zobrazeno 1 - 10
of 26
pro vyhledávání: '"John J. Koleng"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 6, Iss , Pp 100197- (2023)
When preparing siRNA-encapsulated solid lipid nanoparticles (siRNA-SLNs), cationic lipids are commonly included to condense and lipophilize the siRNA and thus increase its encapsulation in the SLNs. Unfortunately, cationic lipids also contribute sign
Externí odkaz:
https://doaj.org/article/ad9078a10a3d4dc7908ea261456cf6ef
Autor:
Sawittree Sahakijpijarn, Chaeho Moon, Zachary N. Warnken, Esther Y. Maier, Jennie E. DeVore, Dale J. Christensen, John J. Koleng, Robert O. Williams, III
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100073- (2021)
Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 leve
Externí odkaz:
https://doaj.org/article/dfe6a274c8314e9c8f760034807a44c2
Autor:
Miguel O. Jara, Zachary N. Warnken, Sawittree Sahakijpijarn, Rishi Thakkar, Vineet R. Kulkarni, Dale J. Christensen, John J. Koleng, Robert O. Williams
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2568 (2022)
Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a
Externí odkaz:
https://doaj.org/article/d5988db7ec374c72851dc142892f2f1e
Autor:
Sawittree Sahakijpijarn, Chaeho Moon, John J. Koleng, Dale J. Christensen, Robert O. Williams
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1002 (2020)
Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for emergency use. To maximize delivery to the lungs, we formulated remdesivir as a dry powder for inhalation using thin film freezing (TFF). TFF produces brittle matri
Externí odkaz:
https://doaj.org/article/d958fe45248f4ac8a1a7de1c0c2dd92d
Publikováno v:
Pharmaceutics, Vol 11, Iss 10, p 498 (2019)
Counterions commonly remain with peptides in salt form after peptide purification. In animal and human studies, acetate counterions are a safer and more acceptable choice for peptides than others (e.g., trifluoroacetate counterions). Various salt for
Externí odkaz:
https://doaj.org/article/713f253994a946bda1cdb550279a1463
Autor:
Ashlee D. Brunaugh, Amanda Walz, Zachary Warnken, Camron Pearce, Juan Munoz Gutierrez, John J. Koleng, Hugh D. C. Smyth, Mercedes Gonzalez-Juarrero
Publikováno v:
Antimicrob Agents Chemother
Tuberculosis (TB) remains a major cause of morbidity and mortality, particularly in low- and middle-income countries where access to health care workers, cold-chain storage, and sterile water sources may be limited. Inhaled drug delivery is a promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae5f5172e3b5704328b39bc639a0dcf
https://doi.org/10.1128/aac.00186-22
https://doi.org/10.1128/aac.00186-22
Publikováno v:
Journal of pharmaceutical sciences.
The feasibility of twin-screw corotating extruder as a continuous process mixer to prepare dry powder inhalation (DPI) powders was investigated. Interactive mixtures of 1% micronized budesonide, 0.3% magnesium stearate and 98.7% alpha-lactose monohyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc420dd8208db222238664cf9581b555
https://pubmed.ncbi.nlm.nih.gov/36228755
https://pubmed.ncbi.nlm.nih.gov/36228755
Autor:
Esther Y. Maier, Chaeho Moon, Sawittree Sahakijpijarn, Jennie E. DeVore, Dale J. Christensen, Zachary N. Warnken, Robert O. Williams, John J. Koleng
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100073-(2021)
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X
Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b901d847665e485e1d0da30a9db2ffad
http://www.sciencedirect.com/science/article/pii/S2590156721000025
http://www.sciencedirect.com/science/article/pii/S2590156721000025
Autor:
Stephanie Hufnagel, Jeanne C. Stachowiak, Wedad Sakran, Andrea N. Trementozzi, Mahmoud S. Hanafy, Zhengrong Cui, John J. Koleng
Publikováno v:
AAPS PharmSciTech. 22
The present study was designed to test the hypothesis that programmed cell death-1 (PD-1) siRNA can downregulate PD-1 expression in macrophages in culture and in tumor tissues in mice and inhibit tumor growth in a mouse model. PD-1 siRNA was encapsul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b991138207a6fd27e3ef900144de5048
https://doi.org/10.1208/s12249-021-01933-y
https://doi.org/10.1208/s12249-021-01933-y
Autor:
Dale J. Christensen, John J. Koleng, Robert O. Williams, Jay I. Peters, Chaeho Moon, Zachary N. Warnken, Miguel O. Jara, Sarah Hackman, Sawittree Sahakijpijarn, Esther Y. Maier
In this work, we have developed and tested in vivo a dry powder form of niclosamide made by thin-film freezing (TFF) and administered it by inhalation to rats and hamsters. The niclosamide dry powder, suitable for inhalation, is being developed as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35536478ec0d3c00f2c1ecc94dcb63ce
https://doi.org/10.1101/2021.01.26.428293
https://doi.org/10.1101/2021.01.26.428293
