Zobrazeno 1 - 10
of 72
pro vyhledávání: '"John J. Keating"'
Autor:
Ryan M. Alam, John J. Keating
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1939-1951 (2021)
The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient
Externí odkaz:
https://doaj.org/article/d59c408b83b84753bae26d03ed18e212
Autor:
Ryan M. Alam, John J. Keating
Publikováno v:
Synthesis. 53:4709-4722
Pyrazolo[3,4-b]pyridine is a privileged scaffold found in many small drug molecules that possess a wide range of pharmacological properties. Efforts to further develop and exploit synthetic methodologies that permit the functionalization of this hete
Autor:
John J. Keating, Ryan M. Alam
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1939-1951 (2021)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
The indazole scaffold represents a promising pharmacophore, commonly incorporated in a variety of therapeutic drugs. Although indazole-containing drugs are frequently marketed as the corresponding N-alkyl 1H- or 2H-indazole derivative, the efficient
Autor:
Andreas Marx, Niklas J. Koehl, René Holm, Brendan T. Griffin, John J. Keating, Thomas De Vijlder, Martin Kuentz, Laura J. Henze
Publikováno v:
Koehl, N J, Henze, L J, Holm, R, Kuentz, M, Keating, J J, De Vijlder, T, Marx, A & Griffin, B T 2022, ' Lipophilic Salts and Lipid-Based Formulations for Bridging the Food Effect Gap of Venetoclax ', Journal of Pharmaceutical Sciences, vol. 111, no. 1, pp. 164-174 . https://doi.org/10.1016/j.xphs.2021.09.008
Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF vehicles. This study investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891f5094421f520bc605cb9eabbe0467
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f
https://portal.findresearcher.sdu.dk/da/publications/8739040f-91e7-49b7-ae10-38595606aa5f
Autor:
Joel L. Plawsky, John J. Keating
Publikováno v:
Macromolecules. 53:7224-7238
Mean radical lifetimes and fluctuations in lifetime are shown to decrease with conversion and polydispersity index for atom transfer radical polymerization (ATRP) of both methyl methacrylate and st...
Autor:
John J. Keating, Ryan M. Alam
Publikováno v:
Drug testing and analysisREFERENCES. 14(2)
Over the past decade, synthetic cannabinoid receptor agonists (SCRAs) have rapidly evolved to encompass a wide range of structurally diverse new psychoactive substances (NPS), including derivatives that incorporate indole, indazole, 7-azaindole, γ-c
Autor:
Simon E. Lawrence, Seán McSweeney, Niamh O'Mahoney, John J. Keating, Sam Hill, Dara Fitzpatrick
Publikováno v:
International journal of pharmaceutics. 580
This research aims to address a gap in our understanding of the mechanisms by which pharmaceutical tablets achieve highly reproducible and predictable drug release. The present industrial and regulatory practice is centred around tablet dissolution,
Autor:
John J. Keating, Ryan M. Alam
Publikováno v:
Drug testing and analysisREFERENCES. 12(3)
Synthetic cannabinoid receptor agonists (SCRAs) first appeared on the international recreational drug market in the early 2000s in the form of SCRA-containing herbal blends. Due to the cannabimimetic effects associated with the consumption of SCRAs,
Publikováno v:
Journal of Membrane Science. 555:30-37
Chiral ligand exchange membranes were synthesized for potential use in racemic filtration applicable to the pharmaceutical industry. Regenerated cellulose membranes with 1 kDa molecular weight cutoff (MWCO) were grafted with chiral L -proline-copper
Publikováno v:
Macromolecules. 50:7930-7939
Solving a comprehensive, yet simple, reaction model for describing the activators regenerated by electron transfer (ARGET)–atom transfer radical polymerization (ATRP) reaction cascade, we show that the molar ratios of transition metal catalyst to i