Zobrazeno 1 - 10
of 125
pro vyhledávání: '"John J. Heikkila"'
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58640 (2013)
The plant growth-promoting bacterium (PGPB) Pseudomonas sp. UW4, previously isolated from the rhizosphere of common reeds growing on the campus of the University of Waterloo, promotes plant growth in the presence of different environmental stresses,
Externí odkaz:
https://doaj.org/article/19a541ac0c254a2f835dfd8f98b7bb6e
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e77027 (2013)
High concentrations of reactive oxygen species (ROS) induce cellular damage, however at lower concentrations ROS act as intracellular second messengers. In this study, we demonstrate that serotonin (5-HT) transactivates the platelet-derived growth fa
Externí odkaz:
https://doaj.org/article/531efd7f7309456391301e2dad7c12cd
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50547 (2012)
In the present study, withaferin A (WA), a steroidal lactone with anti-inflammatory and anti-tumor properties, inhibited proteasome activity and induced endoplasmic reticulum (ER) and cytoplasmic HSP accumulation in Xenopus laevis A6 kidney epithelia
Externí odkaz:
https://doaj.org/article/fd3b64e0d1af41c287786d48d098f6ed
Autor:
John J. Heikkila
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 203:179-192
Small heat shock proteins (sHSPs) are a superfamily of molecular chaperones with important roles in protein homeostasis and other cellular functions. Amphibians, reptiles, fish and birds have a shsp gene called hsp30, which was also referred to as hs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fd43eb89a0a99a18b1285fcb70e405
https://doi.org/10.1016/j.cbpa.2016.09.011
https://doi.org/10.1016/j.cbpa.2016.09.011
Autor:
Cody S. Shirriff, John J. Heikkila
Publikováno v:
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 191:117-128
Endoplasmic reticulum (ER) stress can result in the accumulation of unfolded/misfolded protein in the ER lumen, which can trigger the unfolded protein response (UPR) resulting in the activation of various genes including immunoglobulin-binding protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a960d57ab9847a3b36e7c9b488fd12
https://doi.org/10.1016/j.cbpc.2016.10.003
https://doi.org/10.1016/j.cbpc.2016.10.003
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 201:12-21
Small heat shock proteins (sHSPs) are molecular chaperones that bind to unfolded protein, inhibit the formation of toxic aggregates and facilitate their refolding and/or degradation. Previously, the only sHSPs that have been studied in detail in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6b127c8be6dad355fd57ce99225bde
https://doi.org/10.1016/j.cbpa.2016.06.022
https://doi.org/10.1016/j.cbpa.2016.06.022
Autor:
John J. Heikkila, James H. Campbell
Publikováno v:
Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 210
Cadmium is a highly toxic environmental pollutant that can cause many adverse effects including cancer, neurological disease and kidney damage. Aquatic amphibians are particularly susceptible to this toxicant as it was shown to cause developmental ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994b0bf8954dc5bf146e44ea72149bbb
https://pubmed.ncbi.nlm.nih.gov/29698685
https://pubmed.ncbi.nlm.nih.gov/29698685
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 189:130-140
In the present study, treatment of Xenopus laevis A6 kidney epithelial cells with the proteasomal inhibitor, MG132, or the environmental toxicants, sodium arsenite or cadmium chloride, induced the accumulation of the small heat shock protein, HSP30,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475e58bcc0658c0b6aa0f2a70e533aba
https://doi.org/10.1016/j.cbpa.2015.07.022
https://doi.org/10.1016/j.cbpa.2015.07.022
Autor:
Jeff S. Kruk, Nawaz Ahmed, Michael A. Beazely, Maryam S. Vasefi, John J. Heikkila, Nyasha Gondora
Publikováno v:
Molecular and Cellular Neuroscience. 65:45-51
Many G protein-coupled receptors (GPCRs), including serotonin (5-HT) receptors promote the activity of receptor tyrosine kinases (RTKs) via intracellular signaling pathways in a process termed transactivation. Although transactivation pathways are co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc86c264dd075d068ee29729a19730da
https://doi.org/10.1016/j.mcn.2015.02.013
https://doi.org/10.1016/j.mcn.2015.02.013
Autor:
John J. Heikkila, Imran Khamis
Publikováno v:
Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 204
Numerous studies have elucidated the health benefits of organosulfur compounds, known as isothiocyanates (ITCs), derived from cruciferous vegetables. As electrophiles, ITCs have the ability to directly bind and modify thiol-containing compounds such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6f929c6eafc9817d49d51cf702445f
https://pubmed.ncbi.nlm.nih.gov/29100952
https://pubmed.ncbi.nlm.nih.gov/29100952