Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John J. DeFeo"'
Publikováno v:
Drug Development Research. 2:175-179
Normotensive rats of the Sprague-Dawley strain were administered either the centrally acting hypotensive drug clonidine (0.16 mg/kg IP) or the peripherally acting hypotensive drug hydralazine (1.25 mg/kg IP) to induce reliable hypotension (blood pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f231290c9c297da1b38d6c07245241b
https://doi.org/10.1002/ddr.430020207
https://doi.org/10.1002/ddr.430020207
Publikováno v:
Journal of Pharmaceutical Sciences. 56:1104-1108
Derivatives of cyclohexanol and cyclohexylamine were screened for cardioplegic effects on intact anesthetized rats and isolated guinea pig hearts. Evaluation of potency was based on the ability of the compounds to depress rat carotid blood pressure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c22d965c3297e0380dc76916058b7ef
https://doi.org/10.1002/jps.2600560911
https://doi.org/10.1002/jps.2600560911
Publikováno v:
Journal of Pharmaceutical Sciences. 50:240-244
The roots of Valeriana officinalis were extracted by various solvent extraction procedures and the fractions prepared were tested for their biological activity in an attempt to isolate the most active constituents. Two fractions, V103 and V115, both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b02122038ea100c2c357d7211e21d1
https://doi.org/10.1002/jps.2600500315
https://doi.org/10.1002/jps.2600500315
Autor:
J.A. Bianculli, M.L. Jacquart, John J. DeFeo, R.K. Bickerton, F.M. Schalit, W.J. Hudak, Joseph P. Buckley
Publikováno v:
Journal of the American Pharmaceutical Association (Scientific ed.). 49:586-589
Certain diquaternarized piperidine derivatives and several bis-tertiary amines were evaluated in the anesthetized rat and dog. The most active hypotensive agents were: 3-mor-pholinopropyl N-methylpipecolinate di-methiodide (JB-643), 2-morpholinoethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f5a68e8b70c8431246c16595c913b68
https://doi.org/10.1002/jps.3030490907
https://doi.org/10.1002/jps.3030490907
Publikováno v:
Economic Botany. 15:99-103
Several organic solvent and aqueous extractives were prepared from dried roots ofPleiocarpa mutica Benth. obtained from the Belgium Congo. All aqueous fractions produced a drop in blood pressure when administered to laboratory rats. A moist ethyl ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d852d23a3400b13c5707217bb5c4b39e
https://doi.org/10.1007/bf02906766
https://doi.org/10.1007/bf02906766
Publikováno v:
Toxicology and Applied Pharmacology. 24:298-308
Oral administration of pyrethrum to male rats at 200 mg/kg for 23 days resulted in liver enlargement with decreases in hepatic DNA concentrations. While total lipid concentrations were increased significantly, the increases did not account for the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0333c1c871bfdf9c5f57659638bd3d7a
https://doi.org/10.1016/0041-008x(73)90149-x
https://doi.org/10.1016/0041-008x(73)90149-x
Publikováno v:
Psychopharmacologia. 15:153-158
The duration of hypnosis induced by hexobarbital, pentobarbital, chloral hydrate or barbital was markedly reduced after prolonged social isolation of male mice. Hexobarbital and pentobarbital were affected more than chloral hydrate and barbital. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3e919e7969d410f7c3cdc990569297
https://doi.org/10.1007/bf00407048
https://doi.org/10.1007/bf00407048
Publikováno v:
Journal of the American Pharmaceutical Association (Scientific ed.). 48:404-406
The hypotensive effects of the monophosphoric acid ester of thiamine (RO 1–4788) and thiamine hydrochloride were investigated in anesthetized rats and dogs. The depressor effect of thiamine hydrochloride was 40.8% greater than that or RO 1–4788 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd1b90986a7f6ba674e6cfa4b1b51ace
https://doi.org/10.1002/jps.3030480711
https://doi.org/10.1002/jps.3030480711
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 132(2)
SummaryAcute exposure of mice and rats to hypobaric hypoxia (364 mm Hg, 10% O2) enhanced the depressant effects of sodium barbital, sodium pentobarbital, and chloral hydrate. Mice were far more sensitive than rats, barbital hypnosis being affected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1864aa586545b329b0c80bb407a99a64
https://pubmed.ncbi.nlm.nih.gov/5355117
https://pubmed.ncbi.nlm.nih.gov/5355117
Autor:
John J. DeFeo, Harold H. Smookler
Publikováno v:
Journal of pharmaceutical sciences. 51
Cyclohexanol and its derivatives 2-(o-tolyl), 2-(m-tolyl), 2-(p-tolyl), 2-(o-chlorophenyl), 2-(m-chlorophenyl), and 2-(p-chlorophenyl) were tested for cardioplegic effects on intact anesthetized rats, isolated guinea pig hearts, and isolated rabbit a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd39baaf9ed5bca06da44e523063dde1
https://pubmed.ncbi.nlm.nih.gov/13914513
https://pubmed.ncbi.nlm.nih.gov/13914513