Zobrazeno 1 - 10
of 193
pro vyhledávání: '"John J. Daly"'
Autor:
John J. Daly, Michael Altorfer, Clive Spiegler, Daniel Obrecht, Christian Lehmann, Udo Bohdal, Alexander M. Labhardt, Ruth Ruffieux, Walter Huber, Cornelia Zumbrunn, Klaus Müller, Peter Schönholzer
Publikováno v:
Biopolymers. 42:575-626
The present work describes three novel nonpolar host peptide sequences that provide a ready assessment of the 310- and α-helix compatibilities of natural and unnatural amino acids at different positions of small- to medium-size peptides. The unpolar
Publikováno v:
Tetrahedron. 51:10883-10900
A novel and efficient synthesis of optically pure ( R )- and ( S )-α-methyl glutamic acid ( 1 ), ( R )- and ( S )-α-methyl aspartic acid ( 2a ) and ( R )- and ( S )-α-isobutyl aspartic acid ( 2b ) using L-phenylalanine cyclohexylamide 4 as chiral
Publikováno v:
Tetrahedron. 49:9995-10008
Irradiation of the 2-oxoindeno[1,7-bc]furan-6-carbonitrile 1 in protic solvents with light of 254 nm induces a 1,3-carbalkoxy shift. Supported by X-ray analyses of 2 and 3a it could be shown that the resulting 3,7-dioxo-3H-1,3a-ethano-isobenzofuran-9
Publikováno v:
ChemInform. 25
Irradiation of the 2-oxoindeno[1,7-bc]furan-6-carbonitrile 1 in protic solvents with light of 254 nm induces a 1,3-carbalkoxy shift. Supported by X-ray analyses of 2 and 3a it could be shown that the resulting 3,7-dioxo-3H-1,3a-ethano-isobenzofuran-9
Publikováno v:
ChemInform. 27
Autor:
John J. Daly, Albert Fischli
Publikováno v:
Helvetica Chimica Acta. 63:1628-1643
Hydrogen bonds as presented in Figure 2 cannot account for the enantioselective attack of cob(I)alamin (4(I)) or heptamethyl cob(I)yrinate (5(I)) on one of the two enantiotopic faces of the substrates. The attack of the strongly nucleophilic 3d orbit
Publikováno v:
Helvetica Chimica Acta. 69:887-897
Based on a computer-assisted analysis of the three-dimensional structure of the binary complex of E.coli dihydrofolate reductase (DHFR) with methotrexate, 5-(N-arylnortropan-3-yl)- and 5-(N-arylpiperidin-4-yl)-2,4-diaminopyrimidines 2 and 4 were desi
Publikováno v:
Tetrahedron Letters. 24:343-346
( + )-3-PPP has been resolved by means of (+)- and (-)- 2,2′-(1,1′-binaphthyl)phosphoric acid (BNPPA) in high optical purity; (+)-3-PPP has been assigned the R configuraiton on the basis of a single crystal X-ray analysis.
Publikováno v:
Helvetica Chimica Acta. 67:1827-1842
Under conditions normally applied to transform thioureas into the corresponding carbodiimides, cis- and trans-1-(2-aryl-1,3-dithian-5-yl)-2-thioureas 7 and 8 undergo a rearrangement to 5-aryl-3-imino-7,7a-dihydro-1H, 3H, 5H-thiazolo[3,4-c]thiazoles 9
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 7:31-38
In addition to the well-known quinidine metabolites, 2'-quinidinone and 3-hydroxy-quinidine, a third metabolic product was detected in the plasma of cardiac patients receiving quinidine therapy. Mass spectroscopic, 13C- and 1H-NMR studies, together w