Zobrazeno 1 - 10
of 535
pro vyhledávání: '"John J Voorhees"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 11, Pp 1015-1022 (2012)
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and has a high rate of mortality. Emerging evidence indicates that hepatocyte growth factor receptor (or Met) pathway plays a pivotal role in HNSCC metastasis and resistanc
Externí odkaz:
https://doaj.org/article/0a0478887b6743a08713fe5b27c7f24b
Autor:
William R Swindell, Mrinal K Sarkar, Philip E Stuart, John J Voorhees, James T Elder, Andrew Johnston, Johann E Gudjonsson
Publikováno v:
Clinical and Translational Medicine, Vol 4, Iss 1, Pp n/a-n/a (2015)
Abstract BackgroundPsoriasis is a cytokine‐mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild p
Externí odkaz:
https://doaj.org/article/701228f45ce24c008a69346110a2e7f4
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115402 (2014)
Human skin is a primary target of oxidative stress from reactive oxygen species (ROS) generated from both extrinsic and intrinsic sources. Oxidative stress inhibits the production of collagen, the most abundant protein in skin, and thus contributes t
Externí odkaz:
https://doaj.org/article/3c0f43d417e44b71b5e837caf32763ca
Autor:
William R Swindell, Andrew Johnston, Xianying Xing, John J Voorhees, James T Elder, Johann E Gudjonsson
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79253 (2013)
Whole-genome expression profiling has been used to characterize molecular-level differences between psoriasis lesions and normal skin. Pathway analysis, however, is complicated by the fact that expression profiles have been derived from bulk skin bio
Externí odkaz:
https://doaj.org/article/153bf196dbb6472eaf1289346efeebb2
Autor:
William R Swindell, Xianying Xing, Philip E Stuart, Cynthia S Chen, Abhishek Aphale, Rajan P Nair, John J Voorhees, James T Elder, Andrew Johnston, Johann E Gudjonsson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34594 (2012)
The clinical features of psoriasis, characterized by sharply demarcated scaly erythematous plaques, are typically so distinctive that a diagnosis can easily be made on these grounds alone. However, there is great variability in treatment response bet
Externí odkaz:
https://doaj.org/article/c9c6ca80713f49babc4b79fdb00daf63
Autor:
William R Swindell, Andrew Johnston, Steve Carbajal, Gangwen Han, Christian Wohn, Jun Lu, Xianying Xing, Rajan P Nair, John J Voorhees, James T Elder, Xiao-Jing Wang, Shigetoshi Sano, Errol P Prens, John DiGiovanni, Mark R Pittelkow, Nicole L Ward, Johann E Gudjonsson
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18266 (2011)
Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no s
Externí odkaz:
https://doaj.org/article/457db3053e4b4e1fb3f6cbd23127336d
Autor:
Feiyang Ma, Olesya Plazyo, Allison C. Billi, Lam C. Tsoi, Xianying Xing, Rachael Wasikowski, Mehrnaz Gharaee-Kermani, Grace Hile, Yanyun Jiang, Paul W. Harms, Enze Xing, Joseph Kirma, Jingyue Xi, Jer-En Hsu, Mrinal K. Sarkar, Yutein Chung, Jeremy Di Domizio, Michel Gilliet, Nicole L. Ward, Emanual Maverakis, Eynav Klechevsky, John J. Voorhees, James T. Elder, Jun Hee Lee, J. Michelle Kahlenberg, Matteo Pellegrini, Robert L. Modlin, Johann E. Gudjonsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A a
Externí odkaz:
https://doaj.org/article/7d7e27df0a374d5eb3a7f42f1d8c5e5f
Autor:
Mrinal K. Sarkar, Ranjitha Uppala, Chang Zeng, Allison C. Billi, Lam C. Tsoi, Austin Kidder, Xianying Xing, Bethany E. Perez White, Shuai Shao, Olesya Plazyo, Sirisha Sirobhushanam, Enze Xing, Yanyun Jiang, Katherine A. Gallagher, John J. Voorhees, J. Michelle Kahlenberg, Johann E. Gudjonsson
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
CRISPR/Cas9 has been proposed as a treatment for genetically inherited skin disorders. Here we report that CRISPR transfection activates STING-dependent antiviral responses in keratinocytes, resulting in heightened endogenous interferon (IFN) respons
Externí odkaz:
https://doaj.org/article/2e6f622a55a149e8bca5194f792c60eb
Publikováno v:
Journal of Cell Communication and Signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce6fcbab1fe54211b624aa14bcff580f
https://doi.org/10.1007/s12079-023-00743-0
https://doi.org/10.1007/s12079-023-00743-0
Autor:
Taihao Quan, Wei Xia, Tianyuan He, Kenneth Calderone, George Bou-Gharios, John J. Voorhees, Andrzej A. Dlugosz, Gary J. Fisher
Publikováno v:
Journal of Investigative Dermatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ede3f6a6676d204317f277da721f129
https://doi.org/10.1016/j.jid.2023.02.028
https://doi.org/10.1016/j.jid.2023.02.028