Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John J Upson"'
Autor:
Melissa H Costell, Nicolas eAncellin, Roberta E Bernard, Shufang eZhao, John J Upson, Lisa A Morgan, Kristeen eHauk, Alan R Olzinski, Victoria L T Ballard, Kenny eHerry, Pascal eGrondin, Nerina eDodic, Olivier eMirguet, Anne eBouillot, Francoise eGellibert, Robert W Coatney, John J Lepore, Beat M. Jucker, Larry J Jolivette, Robert N Willette, Christine G Schnackenberg, David J Behm
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis that the cardiovascular protective effects of NO-insensitive sGC ac
Externí odkaz:
https://doaj.org/article/7de0d838ef7f45aba69ae237f3a44947
Autor:
Bao Hoang, Stephen H. Eisennagel, James Tunstead, Shufang Zhao, Alan R. Olzinski, Beat M. Jucker, David J. Behm, Tao Wang, John J. Upson, Joseph P. Marino, Lisa A. Morgan, Robert N. Willette
Publikováno v:
Journal of Cardiovascular Pharmacology. 61:291-301
Epoxyeicosatrienoic acids, substrates for soluble epoxide hydrolase (sEH), exhibit vasodilatory and antihypertrophic activities. Inhibitors of sEH might therefore hold promise as heart failure therapeutics. We examined the ability of sEH inhibitors G
Autor:
John R. Toomey, John J. Upson
Publikováno v:
Drug Discovery Today: Therapeutic Strategies. 9:e199-e203
With a few notable exceptions, heart failure (HF) drug development has faced substantial attrition while translating preclinical discoveries into clinical efficacy. The high attrition has prompted a reconsideration of the target selection process of
Autor:
Charles D. Smith, John J. Upson, Staci N. Keller, Lynn W. Maines, Kevin J. French, Leo R. Fitzpatrick, Yan Zhuang, Zuping Xia
Publikováno v:
Digestive Diseases and Sciences. 53:997-1012
A critical step in the mechanism of action of inflammatory cytokines is the stimulation of sphingolipid metabolism, including activation of sphingosine kinase (SK), which produces the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P).
Autor:
Harry S. Cooper, Eric Ross, Alfonso Bellacosa, Christos Patriotis, Margie L. Clapper, Radka Stoyanova, John J. Upson, Alfred G. Knudson, Bruce M. Boman
Publikováno v:
Journal of Cellular Physiology. 201:366-373
Analysis of cell-specific gene expression patterns using microarrays can reveal genes that are differentially expressed in diseased and normal tissue, as well as identify genes associated with specialized cellular functions. However, the cellular het
Autor:
Ketaki Datta, John J. Upson, Elizabeth P. Henske, Alfred G. Knudson, Radka Stoyanova, Bruce M. Boman, Margie L. Clapper, Christos Patriotis, Eric Ross, Alfonso Bellacosa
Publikováno v:
Journal of Cellular Physiology. 201:359-365
Microarray analysis of human tissue is frequently hindered by the limited amount of RNA available. Although amplification protocols can be utilized, the relative representation of transcripts present in the starting material must remain unaltered. In
Autor:
John J. Lepore, Anne Marie Jeanne Bouillot, Kristeen Maniscalco, Olivier Mirguet, Alan R. Olzinski, Christine G. Schnackenberg, Larry J. Jolivette, John J. Upson, Nerina Dodic, Françoise Gellibert, Lisa A. Morgan, Shu Fang Zhao, Pascal Grondin, Robert W. Coatney, Beat M. Jucker, David J. Behm, Victoria L. T. Ballard, Robert N. Willette, Roberta E. Bernard, Nicolas Ancellin, Kenny Herry, Melissa H. Costell
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Frontiers in Pharmacology
Frontiers in Pharmacology
Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis that the cardiovascular protective effects of NO-insensitive sGC ac
Autor:
Cecelia L. Green, Staci N. Keller, Kevin J. French, Vladimir Beljanski, Yan Zhuang, John J. Upson, Charles D. Smith, Peng Gao, Wenxue Wang, Lynn W. Maines
Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of important bioactive lipids, including the apoptotic compound ceramide and the proliferative compound sphingosine 1-phosphate (S1P). Many growth factors and inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9179ae3d28df0a8fcd9474821e5740b7
https://europepmc.org/articles/PMC2846016/
https://europepmc.org/articles/PMC2846016/
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 318(2)
Sphingosine kinase (SK) is an oncogenic sphingolipid-metabolizing enzyme that catalyzes the formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) at the expense of proapoptotic ceramide. Thus, SK is an attractive target for cancer
N-myristoyltransferases (NMT) add myristate to the NH2 termini of certain proteins, thereby regulating their localization and/or biological function. Using RNA interference, this study functionally characterizes the two NMT isozymes in human cells. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21b8db7870573a0c5a4c090066314cd
https://europepmc.org/articles/PMC2908404/
https://europepmc.org/articles/PMC2908404/