Zobrazeno 1 - 10
of 60
pro vyhledávání: '"John J Talley"'
Autor:
Scott M. Ebert, Celine S. Nicolas, Paul Schreiber, Jaime G. Lopez, Alan T. Taylor, Andrew R. Judge, Sarah M. Judge, Blake B. Rasmussen, John J. Talley, Christophe A. Rème, Christopher M. Adams
Publikováno v:
Animals, Vol 14, Iss 2, p 186 (2024)
Muscle atrophy and weakness are prevalent and debilitating conditions in dogs that cannot be reliably prevented or treated by current approaches. In non-canine species, the natural dietary compound ursolic acid inhibits molecular mechanisms of muscle
Externí odkaz:
https://doaj.org/article/493b01afca24468aa78b04e49c41e4a3
Autor:
Scott M Ebert, Blake B Rasmussen, Andrew R Judge, Sarah M Judge, Lars Larsson, Ronald C Wek, Tracy G Anthony, George R Marcotte, Matthew J Miller, Mark A Yorek, Adrian Vella, Elena Volpi, Jennifer I Stern, Matthew D Strub, Zachary Ryan, John J Talley, Christopher M Adams
Publikováno v:
J Nutr
Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF4 can be expressed in most if not all mammalian cell types, and it can participate in a variety of cellular res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236e79fa0970ae2554bdf964592515da
https://doi.org/10.1093/jn/nxab440
https://doi.org/10.1093/jn/nxab440
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 16:1284-1289
Coxibs are a class of powerful drugs used by millions of people worldwide to treat a wide variety of ailments such as muscular skeletal pain and inflammation. The primary mechanism of action of coxibs is the potent inhibition of the COX-2 enzyme. Unf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5667668392996340f2a2b9f2b980179b
https://doi.org/10.2174/1389557515666160509125702
https://doi.org/10.2174/1389557515666160509125702
Autor:
Steven A. Bullard, Daryl J. Murry, Daniel K. Fox, Jason M. Dierdorff, Christopher M. Adams, Kale S. Bongers, Michael C. Dyle, David K. Meyerholz, John J. Talley, Scott M. Ebert, Vitor A. Lira
Publikováno v:
The Journal of Biological Chemistry
Background: Aging reduces skeletal muscle strength and mass. Results: The transcription factor ATF4 is required for age-related muscle weakness and atrophy, and the small molecules ursolic acid and tomatidine reduce ATF4 activity, weakness, and atrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd5905feec44a2516502d0e1ea01096
https://doi.org/10.1074/jbc.m115.681445
https://doi.org/10.1074/jbc.m115.681445
Synthesis and Evaluation of Novel Erlotinib–NSAID Conjugates as More Comprehensive Anticancer Agents
Autor:
Micky D. Tortorella, Guan Jiantong, Jinfeng Luo, Yanmei Zhang, Jinxi Liao, Xiao-Chu Qin, Tingting Chen, Zhengchao Tu, John J. Talley
Publikováno v:
ACS Medicinal Chemistry Letters. 6:1086-1090
A series of novel anticancer agents were designed and synthesized based on coupling of different nonsteroidal anti-inflammatory drugs (NSAIDs) with the epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitor, erlotinib. Both the antiprolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458e9129a7996fbce34a05cec8eb1862
https://doi.org/10.1021/acsmedchemlett.5b00286
https://doi.org/10.1021/acsmedchemlett.5b00286
Autor:
John J. Talley, Jingfang Xiong, He Chuang, Wang Yican, Zhengchao Tu, Micky D. Tortorella, Miaoqin She, Minke Li, Yanmei Zhang, Yongzhi Lu, Xiao-Chu Qin, Qiong Pan, Tingting Chen, Xiaorong Liu
Publikováno v:
Journal of medicinal chemistry. 60(10)
In this report, we disclose the design and synthesis of a series of pentafluorosulfanyl (SF5) benzopyran derivatives as novel COX-2 inhibitors with improved pharmacokinetic and pharmacodynamic properties. The pentafluorosulfanyl compounds showed both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b520051764e992d89adfda93ea005810
https://pubmed.ncbi.nlm.nih.gov/28475316
https://pubmed.ncbi.nlm.nih.gov/28475316
Autor:
John J. Talley, Liu Jianqi, Dingsheng Wen, Lu Xin, Zhengchao Tu, Micky D. Tortorella, Yanmei Zhang, Xiaorong Liu, Wang Yican, Yang Bai, Yongzhi Lu
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1162-1166
We designed a series of specifically deuterated benzopyran analogues as new COX-2 inhibitors with the aim of improving their pharmacokinetic properties. As expected, the deuterated compounds retained potency and selectivity for COX-2. The new molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3e9f87ca285f9c8680afc1e0307307
https://doi.org/10.1021/ml500299q
https://doi.org/10.1021/ml500299q
Publikováno v:
The Open Organic Chemistry Journal. 7:15-20
Palladium catalysis is an efficient way to obtain trimethylsilyl substituted benzopyran derivatives. After screen- ing a series of reactions , we found optimized conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45b37455624b42a18e4700b74e9ffa71
https://doi.org/10.2174/1874095201307010015
https://doi.org/10.2174/1874095201307010015
Autor:
Ann E. Hallinan, Jeffery S. Carter, David G. Brown, John J. Talley, Timothy Maziasz, Karl W. Aston, Bruce C. Hamper, Matthew J. Graneto, Koszyk Francis, Jaime L. Masferrer, Ludwig Cindy L, Jane L. Wang, David C. Limburg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7164-7168
In this manuscript, we report the discovery of the substituted 2-trifluoromethyl-2H-benzopyran-3-carboxylic acids as a novel series of potent and selective cyclooxygenase-2 (COX-2) inhibitors. We provide the structure–activity relationships, optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca972ff580b09dc552a085ce8062ac97
https://doi.org/10.1016/j.bmcl.2010.07.059
https://doi.org/10.1016/j.bmcl.2010.07.059