Výsledky vyhledávání - "John J Orloff"

Akademický článek

Innovative approaches to clinical development and trial design

Publikováno v: Annali dell'Istituto Superiore di Sanità, Vol 47, Iss 1, Pp 8-13 (2011)

Pharmaceutical innovation is increasingly risky, costly and at times inefficient, which has led to a decline in industry productivity. Despite the increased investment in R&D by the industry, the number of new molecular entities achieving marketing a

Externí odkaz: https://doaj.org/article/3094b39fe4894f298f19e7021c600d85

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Interspecies comparison of renal cortical receptors for parathyroid hormone and parathyroid hormone-related protein

Autor: Douglas Goumas, Andrew F. Stewart, John J. Orloff, Terence Wu

Publikováno v: Journal of Bone and Mineral Research. 6:279-287

Parathyroid hormone (PTH) and PTH-related proteins (PTHrP) interact with a common receptor in rat bone cells and in canine renal membranes with similar affinity, but PTHrP are substantially less potent than PTH in stimulating adenylate cyclase in can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228fbb318f8c54ddd432673239e98c5a
https://doi.org/10.1002/jbmr.5650060310

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Change in Bone Turnover and Hip, Non-Spine, and Vertebral Fracture in Alendronate-Treated Women: The Fracture Intervention Trial

Autor: John J. Orloff, Susan K. Ewing, Desmond E. Thompson, Dennis M. Black, Marc C. Hochberg, Pierre D. Delmas, Douglas C. Bauer, Susan M. Ott, P. Garnero

Publikováno v: Journal of Bone and Mineral Research. 19:1250-1258

We used data from the Fracture Intervention Trial to assess the relationship change in bone turnover after 1 year of alendronate or placebo treatment and subsequent hip, non-spine, and spine fracture risk among 6186 postmenopausal women. In the alend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb42c09ec39f80103e32c3eace59fb6
https://doi.org/10.1359/jbmr.040512

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Therapeutic equivalence of alendronate 35 milligrams once weekly and 5 milligrams daily in the prevention of postmenopausal osteoporosis

Autor: Henry G. Bone, Tobias J. de Villiers, Nigel Gilchrist, Mei X. Wu, Daifotis Anastasia G, John J. Orloff, Arthur C. Santora, Marjorie M Luckey, Michael W Davie

Publikováno v: Obstetrics & Gynecology. 101:711-721

To evaluate the efficacy and safety of alendronate 35 mg once weekly compared with alendronate 5 mg daily in the prevention of osteoporosis.We compared the efficacy and safety of treatment with alendronate 35 mg once weekly (n = 362) and alendronate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45c98f4ba7266d01fb63b56318ef563
https://doi.org/10.1016/s0029-7844(03)00008-5

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Expression and Role of Parathyroid Hormone-Related Protein in Human Renal Proximal Tubule Cells during Recovery from ATP Depletion

Autor: Kai Yang, Scott K. Van Why, Lina Golovyan, Andrew F. Stewart, Richard A. Zager, Susan C. Galbraith, Norman J. Siegel, Pamela Dann, John J. Orloff, Adolfo Garcia-Ocaña

Publikováno v: Journal of the American Society of Nephrology. 10:238-244

Parathyroid hormone (PTH)-related protein (PTHrP) is widely expressed in normal fetal and adult tissues and regulates growth and differentiation in a number of organ systems. Although various renal cell types produce PTHrP, and PTHrP expression in ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232b7f2b793faeea4962110f40936e81
https://doi.org/10.1681/asn.v102238

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Stromal Cells Are Critical Targets in the Regulation of Mammary Ductal Morphogenesis by Parathyroid Hormone-Related Protein

Autor: James F. McCaughern-Carucci, John J. Wysolmerski, Andrew C. Karaplis, Peter Young, Jian Ping Zhang, Gerald R. Cunha, Maureen E. Dunbar, John J. Orloff, Beate Lanske

Publikováno v: Developmental Biology. 203(1):75-89

Parathyroid hormone-related protein (PTHrP) was originally identified as the tumor product responsible for humoral hypercalcemia of malignancy. It is now known that PTHrP is produced by many normal tissues in which it appears to play a role as a deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfe34883edb20c7de11947f45c60f71

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A midregion parathyroid hormone-related peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line

Autor: C M Isales, M S Moyer, M Mitnick, A Behal, J Gasalla-Herraiz, Y Kats, John J. Orloff, M H Nathanson, Michael B. Ganz

Publikováno v: Endocrinology. 137:5376-5385

A midregion fragment of PTH-related protein (PTHrP), which is intensively conserved across species, has been identified as a secretory product of several different cell types, including keratinocytes and squamous carcinomas. As recent data suggest th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490337e9f8dbeb61d3fd49dbb4002918
https://doi.org/10.1210/endo.137.12.8940360

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Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines

Autor: Yuliya Kats, Gino V. Segre, Ernestina Schipani, Abdul B. Abou-Samra, Pablo Urena, John J. Orloff, Rupangi C. Vasavada, William M. Philbrick, Amita Behal, Harald Jüppner

Publikováno v: Endocrinology. 136:3016-3023

PTH and PTH-related peptides (PTHrPs) interact with a common PTH/PTHrP receptor (type I), which is expressed in many tissues, including bone and kidney. Amino-terminal PTH and PTHrPs also recognize receptors in several nonclassical PTH target tissues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90d06cd422e85439166b9b72ff08de6
https://doi.org/10.1210/endo.136.7.7789327

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