Zobrazeno 1 - 10
of 444
pro vyhledávání: '"John J O'Shea"'
Autor:
Alejandro Villarino, John J O'Shea
Publikováno v:
eLife, Vol 6 (2017)
Engineered molecules based on human cytokines have potential uses in research and medicine.
Externí odkaz:
https://doaj.org/article/8fa11568a5934ebda5a066cab88bdb97
Autor:
Alejandro Villarino, Arian Laurence, Gertraud W Robinson, Michael Bonelli, Barbara Dema, Behdad Afzali, Han-Yu Shih, Hong-Wei Sun, Stephen R Brooks, Lothar Hennighausen, Yuka Kanno, John J O'Shea
Publikováno v:
eLife, Vol 5 (2016)
The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain. Using mouse models of paral
Externí odkaz:
https://doaj.org/article/8af0f5efd04c4cec9fea78be48111138
Autor:
Bernard Khor, John D Gagnon, Gautam Goel, Marly I Roche, Kara L Conway, Khoa Tran, Leslie N Aldrich, Thomas B Sundberg, Alison M Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H Tan, Atul K Bhan, Rahul Roychoudhuri, Nicholas P Restifo, John J O'Shea, Benjamin D Medoff, Alykhan F Shamji, Stuart L Schreiber, Arlene H Sharpe, Stanley Y Shaw, Ramnik J Xavier
Publikováno v:
eLife, Vol 4 (2015)
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dua
Externí odkaz:
https://doaj.org/article/8d529be262854d4f87b10c044565271a
Autor:
Paul W Bible, Yuka Kanno, Lai Wei, Stephen R Brooks, John J O'Shea, Maria I Morasso, Rasiah Loganantharaj, Hong-Wei Sun
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127285 (2015)
Comparative co-localization analysis of transcription factors (TFs) and epigenetic marks (EMs) in specific biological contexts is one of the most critical areas of ChIP-Seq data analysis beyond peak calling. Yet there is a significant lack of user-fr
Externí odkaz:
https://doaj.org/article/6bbeff2b722e4c9cb79ddbe48f79c6c7
Autor:
Adewole Adamson, Kamran Ghoreschi, Matthew Rittler, Qian Chen, Hong-Wei Sun, Golnaz Vahedi, Yuka Kanno, William G Stetler-Stevenson, John J O'Shea, Arian Laurence
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59367 (2013)
CD4(+) T helper (Th) cells differentiate into distinct effector subsets that are critical for host defense, but are also implicated in the pathogenesis of autoimmune disorders. Thelper17 (Th17) cells in particular are emerging as important drivers of
Externí odkaz:
https://doaj.org/article/4500c340d896431282bb6da13789825a
Autor:
Mingzhu Zheng, Chen Yao, Gang Ren, Kairui Mao, Hyunwoo Chung, Xi Chen, Gangqing Hu, Lei Wang, Xuemei Luan, Difeng Fang, Dan Li, Chao Zhong, Xiaoxiao Lu, Nikki Cannon, Mingxu Zhang, Avinash Bhandoola, Keji Zhao, John J. O’Shea, Jinfang Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112924- (2023)
Summary: Lymphoid tissue inducer (LTi) cells, a subset of innate lymphoid cells (ILCs), play an essential role in the formation of secondary lymphoid tissues. However, the regulation of the development and functions of this ILC subset is still elusiv
Externí odkaz:
https://doaj.org/article/4cb729c112134e7699da22a5b22d9952
Autor:
Aaron B. Schultz, David G. Kugler, Luis Nivelo, Nicolas Vitari, Laura P. Doyle, Svetlana Ristin, Lothar Hennighausen, John J. O’Shea, Dragana Jankovic, Alejandro V. Villarino
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Infection-induced T cell responses must be properly tempered and terminated to prevent immuno-pathology. Using transgenic mice, we demonstrate that T cell intrinsic STAT1 signaling is required to curb inflammation during acute infection with Toxoplas
Externí odkaz:
https://doaj.org/article/3e59858e0a884f7fbde36c2acc2d7a32
Autor:
Sneha Butala, Leslie Castelo-Soccio, Rishi Seshadri, Eric L. Simpson, John J. O’Shea, Thomas Bieber, Amy S. Paller
Publikováno v:
The Journal of Allergy and Clinical Immunology: In Practice. 11:1361-1373
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The precise control of cytokine production by innate lymphoid cells (ILCs) and their T cell adaptive system counterparts is critical to mounting a proper host defense immune response without inducing collateral damage and autoimmunity. Unlike T cells
Externí odkaz:
https://doaj.org/article/a384158720d147568e23778c7954183a
Autor:
Gabriela M. Wiedemann, Simon Grassmann, Colleen M. Lau, Moritz Rapp, Alejandro V. Villarino, Christin Friedrich, Georg Gasteiger, John J. O’Shea, Joseph C. Sun
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108498- (2020)
Summary: Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell
Externí odkaz:
https://doaj.org/article/cd2ef75af09d4bb1bf1ac555481e0d9d