Zobrazeno 1 - 10
of 107
pro vyhledávání: '"John J O'Neil"'
Autor:
Tetsu Oura, Dicken S. C. Ko, Svjetlan Boskovic, John J. O'neil, Vaja Chipashvili, Maria Koulmanda, Kiyohiko Hotta, Kento Kawai, Ognjenka Nadazdin, R. Neal Smith, A. B. Cosimi, Tatsuo Kawai M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 25 (2016)
We have previously reported successful induction of transient mixed chimerism and long-term acceptance of renal allografts in MHC mismatched nonhuman primates. In this study, we attempted to extend this tolerance induction approach to islet allograft
Externí odkaz:
https://doaj.org/article/c12157fb3b5749818096b09dc2adfafb
Autor:
Yukihide Yonekawa, Shinichi Matsumoto Ph.D., Teru Okitsu, Takashi Arata, Yasuhiro Iwanaga, Hirofumi Noguchi, Hideo Nagata, John J. O'neil, Koichi Tanaka
Publikováno v:
Cell Transplantation, Vol 14 (2005)
Achieving good islet isolation is one of the most important factors for successful islet transplantation. Porcine pancreas is suitable for islet isolation research due to its anatomical and physiological similarities to human pancreas. In this study,
Externí odkaz:
https://doaj.org/article/009b04165b834fad8d5044fc5b003fc3
Autor:
John J. O'neil, Vaja Tchipashvili, Richard J. Parent, Obinna Ugochukwu, Gaurav Chandra, Maria Koulmanda, Dicken Ko, Tatsuo Kawai
Publikováno v:
Cell Transplantation, Vol 12 (2003)
Recent advances in islet cell transplantation have led to insulin independence in a majority of islet transplant recipients. However, there exists a need to overcome the shortage of donor tissue and the necessity for lifelong immunosuppression. Precl
Externí odkaz:
https://doaj.org/article/8ad7582215564914a75d7b0de82ae6de
Autor:
John J. O'neil, Jan P. Stegemann, Donald T. Nicholson, Kerry A. Gagnon, Barry A. Solomon, Claudy J.-P. Mullon
Publikováno v:
Cell Transplantation, Vol 10 (2001)
The efficacy of clinical islet transplantation has been demonstrated with autografts, and although islet allografts have established insulin independence in a small number of IDDM patients, the treatment is confounded by the necessity of immunosuppre
Externí odkaz:
https://doaj.org/article/7c00e7753ded4965a4ade0cf947f3f7e
Publikováno v:
Cell Transplantation, Vol 7 (1998)
Accurate and consistent measurement of tissue volume is critical to performing many types of islet research; however, conventional visual determination of isolated islet yields through a microscope is heavily operator dependent. An improved method of
Externí odkaz:
https://doaj.org/article/dc6d8c817bc647b68284bf684eb7e950
Autor:
Jean Xu, Timothy J. Kieffer, John J. O'Neil, Jennifer E. Bruin, Kavitha Narayan, Jessica K. Fox, Alireza Rezania
Publikováno v:
Stem Cells. 31:2432-2442
Human embryonic stem cells (hESCs) are considered a potential alternative to cadaveric islets as a source of transplantable cells for treating patients with diabetes. We previously described a differentiation protocol to generate pancreatic progenito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6ca8e940954fba7c10d0ecafe6fefa
https://doi.org/10.1002/stem.1489
https://doi.org/10.1002/stem.1489
Autor:
John J. O'Neil, Kavitha Narayan, Jean Xu, Timothy J. Kieffer, Jessica K. Fox, Alireza Rezania, Jennifer E. Bruin
Publikováno v:
Diabetologia. 56:1987-1998
Islet transplantation is a promising cell therapy for patients with diabetes, but it is currently limited by the reliance upon cadaveric donor tissue. We previously demonstrated that human embryonic stem cell (hESC)-derived pancreatic progenitor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933f98bd8751768a3eef680d968c8d65
https://doi.org/10.1007/s00125-013-2955-4
https://doi.org/10.1007/s00125-013-2955-4
Autor:
Jean Xu, Timothy J. Kieffer, Ali Asadi, Ziliang Ao, Garth L. Warnock, Alireza Rezania, Jennifer E. Bruin, Francis Karanu, Rebecca Gauvin, Kavitha Narayan, Michael J. Riedel, John J. O'Neil, Majid Mojibian
Publikováno v:
Diabetes
Diabetes is a chronic debilitating disease that results from insufficient production of insulin from pancreatic β-cells. Islet cell replacement can effectively treat diabetes but is currently severely limited by the reliance upon cadaveric donor tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c6742e4fcef41a3ce09cb92284ee44
https://doi.org/10.2337/db11-1711
https://doi.org/10.2337/db11-1711
Autor:
Abdulkadir Omer, Gordon C. Weir, Vaja Tchipashvili, Susan Bonner-Weir, Clark K. Colton, Anna Pisania, John J. O'Neil, Ji Lei
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
PMC
PMC
Author Manuscript 2011 May 1.
Despite improvements in outcomes for human islet transplantation, characterization of islet preparations remains poorly defined. This study used both light microscopy (LM) and electron microscopy (EM) to characteriz
Despite improvements in outcomes for human islet transplantation, characterization of islet preparations remains poorly defined. This study used both light microscopy (LM) and electron microscopy (EM) to characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c19ac1890e57ce968ec23e57ddd2e5
http://europepmc.org/articles/PMC2966538
http://europepmc.org/articles/PMC2966538
Autor:
Antonello Pileggi, John J. O'Neil, Norman M. Kenyon, Camillo Ricordi, Norma S. Kenyon, Dora M. Berman, Philippe C.J. Chaffanjon, Lane C.K. Coffey, Phillip Ruiz
Publikováno v:
American Journal of Transplantation. 9:91-104
The aim of this study was to test whether an omental pouch can be used as an alternative site for islet implantation in diabetic monkeys. Here we report the successful engraftment of islets in diabetic cynomolgus monkeys when loaded on a synthetic bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe141358a7de0ca606c0296c802e1ae0
https://doi.org/10.1111/j.1600-6143.2008.02489.x
https://doi.org/10.1111/j.1600-6143.2008.02489.x