Zobrazeno 1 - 10
of 300
pro vyhledávání: '"John J Mullins"'
Autor:
Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, Christopher J Kenyon
Publikováno v:
Endocrine Connections, Vol 6, Iss 7, Pp 446-457 (2017)
Chronic ACTH exposure is associated with adrenal hypertrophy and steroidogenesis. The underlying molecular processes in mice have been analysed by microarray, histological and immunohistochemical techniques. Synacthen infused for 2 weeks markedly inc
Externí odkaz:
https://doaj.org/article/604365f401a94798b5d7a9d9fb79dcb4
Autor:
Josselin Nespoux, Marie-Louise T. Monaghan, Natalie K. Jones, Kevin Stewart, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expre
Externí odkaz:
https://doaj.org/article/3754b0ae722445b28dc0fc7b7de55dfa
Autor:
Karen Featherstone, Kirsty Hey, Hiroshi Momiji, Anne V McNamara, Amanda L Patist, Joanna Woodburn, David G Spiller, Helen C Christian, Alan S McNeilly, John J Mullins, Bärbel F Finkenstädt, David A Rand, Michael RH White, Julian RE Davis
Publikováno v:
eLife, Vol 5 (2016)
Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living cells over
Externí odkaz:
https://doaj.org/article/4711de80f72b4aca95bc49e34466bac3
Autor:
Sebastian Pieperhoff, Kathryn S Wilson, James Baily, Kim de Mora, Sana Maqsood, Sharron Vass, Jonathan Taylor, Jorge Del-Pozo, Calum A MacRae, John J Mullins, Martin A Denvir
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96771 (2014)
The zebrafish is increasingly used for cardiovascular genetic and functional studies. We present a novel protocol to maintain and monitor whole isolated beating adult zebrafish hearts in culture for long-term experiments. Excised whole adult zebrafis
Externí odkaz:
https://doaj.org/article/ed6c2c201f444edba1e94c2d77b09827
Autor:
Robert I Menzies, Robert John Unwin, Ranjan K Dash, Daniel A Beard, Allen W Cowley, Brian E Carlson, John J Mullins, Matthew A Bailey
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Reduced glomerular filtration, hypertension and renal microvascular injury are hallmarks of chronic kidney disease, which has a global prevalence of ~10%. We have shown previously shown that the Fischer (F344) rat has lower GFR than the Lewis rat, an
Externí odkaz:
https://doaj.org/article/fce18699015f4cb78b8cc1fcf9132830
Autor:
Bart F J Heijnen, Jelly Nelissen, Helma van Essen, Gregorio E Fazzi, Jan W Cohen Tervaert, Carine J Peutz-Kootstra, John J Mullins, Casper G Schalkwijk, Ben J A Janssen, Harry A J Struijker-Boudier
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57815 (2013)
Transient activation of the renin-angiotensin system (RAS) induces irreversible renal damage causing sustained elevation in blood pressure (BP) in Cyp1a1-Ren2 transgenic rats. In our current study we hypothesized that activation of the AT1-receptor (
Externí odkaz:
https://doaj.org/article/525f71f65d8845759ce3f3b41dd5aaf8
Activation of thiazide-sensitive co-transport by angiotensin II in the cyp1a1-Ren2 hypertensive rat.
Autor:
Ali Ashek, Robert I Menzies, Linda J Mullins, Christopher O C Bellamy, Anthony J Harmar, Christopher J Kenyon, Peter W Flatman, John J Mullins, Matthew A Bailey
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36311 (2012)
Transgenic rats with inducible expression of the mouse Ren2 gene were used to elucidate mechanisms leading to the development of hypertension and renal injury. Ren2 transgene activation was induced by administration of a naturally occurring aryl hydr
Externí odkaz:
https://doaj.org/article/54047f7466664a23a9d55dee0886b846
Autor:
Claire V Harper, Bärbel Finkenstädt, Dan J Woodcock, Sönke Friedrichsen, Sabrina Semprini, Louise Ashall, David G Spiller, John J Mullins, David A Rand, Julian R E Davis, Michael R H White
Publikováno v:
PLoS Biology, Vol 9, Iss 4, p e1000607 (2011)
In individual mammalian cells the expression of some genes such as prolactin is highly variable over time and has been suggested to occur in stochastic pulses. To investigate the origins of this behavior and to understand its functional relevance, we
Externí odkaz:
https://doaj.org/article/188cf6c3240644bba2dec08fe24b29a3
Autor:
Mikhail Liskovykh, Ilya Chuykin, Ashish Ranjan, Dina Safina, Elena Popova, Elena Tolkunova, Valentina Mosienko, Julia M Minina, Natalia S Zhdanova, John J Mullins, Michael Bader, Natalia Alenina, Alexey Tomilin
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27345 (2011)
The rat represents an important animal model that, in many respects, is superior to the mouse for dissecting behavioral, cardiovascular and other physiological pathologies relevant to humans. Derivation of induced pluripotent stem cells from rats (ri
Externí odkaz:
https://doaj.org/article/74b1ba3a139f4c929b2668fb6f3c4ba8
Autor:
Stephen Meek, Mia Buehr, Linda Sutherland, Alison Thomson, John J Mullins, Andrew J Smith, Tom Burdon
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14225 (2010)
The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombina
Externí odkaz:
https://doaj.org/article/8c371ef902a24926b1013cf4c7153a9b