Zobrazeno 1 - 10
of 29
pro vyhledávání: '"John J M, Wiener"'
Autor:
Mark S. Tichenor, John J. M. Wiener, Navin L. Rao, Genesis M. Bacani, Jianmei Wei, Charlotte Pooley Deckhut, J. Kent Barbay, Kevin D. Kreutter, Leon Chang, Kathleen W. Clancy, Heather E. Murrey, Weixue Wang, Kay Ahn, Michael Huber, Elizabeth Rex, Kevin J. Coe, Jiejun Wu, Haopeng Rui, Kia Sepassi, Marcello Gaudiano, Mariette Bekkers, Ivo Cornelissen, Kathryn Packman, Mark Seierstad, Christos Xiouras, Scott D. Bembenek, Richard Alexander, Cynthia Milligan, Sriram Balasubramanian, Alec D. Lebsack, Jennifer D. Venable, Ulrike Philippar, James P. Edwards, Gavin Hirst
Publikováno v:
Journal of Medicinal Chemistry. 65:14326-14336
Bruton's tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in leukocytes. Pharmacological inhibition of BTK has been shown to be effective in treating hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b6932f837c19dc6e82c72e8534354a
https://doi.org/10.1021/acs.jmedchem.2c01026
https://doi.org/10.1021/acs.jmedchem.2c01026
Autor:
Jennifer D. Venable, Weixue Wang, Jianmei Wei, Heather E. Murrey, Mark S. Tichenor, Kristi A. Leonard, Michael Huber, Alec D. Lebsack, Genesis M. Bacani, Scott D. Bembenek, Kay Ahn, J. Kent Barbay, Leon Chang, Kevin D. Kreutter, Navin Rao, Charlotte Pooley Deckhut, Jiejun Wu, Kevin J. Coe, Elizabeth B. Rex, John J. M. Wiener, James P. Edwards, Mark Seierstad
Publikováno v:
ACS Med Chem Lett
[Image: see text] Bruton’s tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in the pathology of autoimmune disorders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422ec59592fb7660a28bf2fbdb3405aa
https://doi.org/10.1021/acsmedchemlett.1c00044
https://doi.org/10.1021/acsmedchemlett.1c00044
Autor:
Karlsson Lars, Siquan Sun, Michael K. Ameriks, Steven Nguyen, Karen Ngo, Jian Zhu, Cheryl A. Grice, Robin L. Thurmond, Sandra R. Chaplan, Hui Cai, William A. Eckert, John J. M. Wiener, James P. Edwards, Wai-Ping Fung-Leung
Publikováno v:
European journal of pharmacology. 880
Cathepsin S (CatS) is a cysteine protease found in lysosomes of hematopoietic and microglial cells and in secreted form in the extracellular space. While CatS has been shown to contribute significantly to neuropathic pain, the precise mechanisms rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98fa503c8295a69f63ca771b32e624f
https://pubmed.ncbi.nlm.nih.gov/32437743
https://pubmed.ncbi.nlm.nih.gov/32437743
Autor:
Taraneh Mirzadegan, Navin Rao, Alec D. Lebsack, Kelly L. Damm-Ganamet, Nidhi Arora, John J. M. Wiener, James P. Edwards, Stéphane Bécart, Lori Westover, Marina I. Nelen, Heather M. McAllister
Publikováno v:
Journal of chemical information and modeling. 59(5)
At the onset of a drug discovery program, the goal is to identify novel compounds with appropriate chemical features that can be taken forward as lead series. Here, we describe three prospective case studies, Bruton Tyrosine Kinase (BTK), RAR-Related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbade40c3c722e76c4ce85a5dd9e29c6
https://pubmed.ncbi.nlm.nih.gov/30817167
https://pubmed.ncbi.nlm.nih.gov/30817167
Publikováno v:
2018 Medicinal Chemistry Reviews ISBN: 9780996293266
2018 Medicinal Chemistry Reviews
2018 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f003bdeca91cfc339a7146a62704601
https://doi.org/10.29200/acsmedchemrev-v53.ch23
https://doi.org/10.29200/acsmedchemrev-v53.ch23
Autor:
Jonathan M. Blevitt, Arlene L. Young, Xiaohua Xue, Genesis M. Bacani, Aimee Rose de Leon, Alejandro Santillan, Adrienne M. Landry-Bayle, Aaron M. Kearney, John J. M. Wiener, Laurent Gomez, Anne M. Fourie, Jason P. Riley, Krystal Herman, Christa C. Chrovian, Cheryl A. Grice, Shelby Crawford, Jay Nelson, Alice Lee-Dutra, Virginia M. Tanis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7504-7511
Previously, benzthiazole containing LTA4H inhibitors were discovered that were potent (1–3), but were associated with the potential for a hERG liability. Utilizing medicinal chemistry first principles (e.g., introducing rigidity, lowering c Log D)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a5468ed5af090759b0400d5ef00168
https://doi.org/10.1016/j.bmcl.2012.10.036
https://doi.org/10.1016/j.bmcl.2012.10.036
Publikováno v:
Journal of Chemical Information and Modeling. 51:1122-1131
We introduce Single R-Group Polymorphisms (SRPs, pronounced 'sharps'), an intuitive framework for analyzing substituent effects and activity cliffs in a single congeneric series. A SRP is a pair of compounds that differ only in a single R-group posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c97cf7b2301fb9dc2d65c18ed8955f
https://doi.org/10.1021/ci200054u
https://doi.org/10.1021/ci200054u
Publikováno v:
Journal of Medicinal Chemistry. 53:5002-5011
We introduce Scaffold Explorer, an interactive tool that allows medicinal chemists to define hierarchies of chemical scaffolds and use them to explore their project data. Scaffold Explorer allows the user to construct a tree, where each node correspo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46bf56f38a11a017e19a0e573655989
https://doi.org/10.1021/jm1004495
https://doi.org/10.1021/jm1004495
Publikováno v:
Current Topics in Medicinal Chemistry. 10:717-732
Cathepsin S has been of increasing interest as a target of medicinal chemistry efforts given its role in modulating antigen-presentation by major histocompatibility class II (MHC II) molecules as well as its involvement in extracellular proteolytic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825b0118f8179b8dbf0ee10e4b22e93f
https://doi.org/10.2174/156802610791113432
https://doi.org/10.2174/156802610791113432
Autor:
Cheryl A. Grice, John J. M. Wiener
Publikováno v:
Organic Process Research & Development. 13:1395-1400
A new protocol of incompatible chemical reagent segregation has been developed. Serving as a second-level segregation beyond typical first-level separation of explosives/nonexplosives, flammables/nonflammables, corrosives/noncorrosives, and caustics/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::585953bebe6503649aa62f8a9c85fa0a
https://doi.org/10.1021/op900094d
https://doi.org/10.1021/op900094d