Zobrazeno 1 - 10
of 189
pro vyhledávání: '"John J Lima"'
Autor:
Amber Dahlin, Augusto Litonjua, John J Lima, Mayumi Tamari, Michiaki Kubo, Charles G Irvin, Stephen P Peters, Kelan G Tantisira
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129385 (2015)
BACKGROUND:Genome-wide association study (GWAS) is a powerful tool to identify novel pharmacogenetic single nucleotide polymorphisms (SNPs). Leukotriene receptor antagonists (LTRAs) are a major class of asthma medications, and genetic factors contrib
Externí odkaz:
https://doaj.org/article/4ab324fa5bef4d5cb63c19d71a085d9d
Autor:
Blanca E Himes, Keith Sheppard, Annerose Berndt, Adriana S Leme, Rachel A Myers, Christopher R Gignoux, Albert M Levin, W James Gauderman, James J Yang, Rasika A Mathias, Isabelle Romieu, Dara G Torgerson, Lindsey A Roth, Scott Huntsman, Celeste Eng, Barbara Klanderman, John Ziniti, Jody Senter-Sylvia, Stanley J Szefler, Robert F Lemanske, Robert S Zeiger, Robert C Strunk, Fernando D Martinez, Homer Boushey, Vernon M Chinchilli, Elliot Israel, David Mauger, Gerard H Koppelman, Dirkje S Postma, Maartje A E Nieuwenhuis, Judith M Vonk, John J Lima, Charles G Irvin, Stephen P Peters, Michiaki Kubo, Mayumi Tamari, Yusuke Nakamura, Augusto A Litonjua, Kelan G Tantisira, Benjamin A Raby, Eugene R Bleecker, Deborah A Meyers, Stephanie J London, Kathleen C Barnes, Frank D Gilliland, L Keoki Williams, Esteban G Burchard, Dan L Nicolae, Carole Ober, Dawn L DeMeo, Edwin K Silverman, Beverly Paigen, Gary Churchill, Steve D Shapiro, Scott T Weiss
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56179 (2013)
Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with mouse AHR and human asthma-
Externí odkaz:
https://doaj.org/article/b7148e73eae544b695d4b1d016395c4e
Autor:
Blanca E Himes, Xiaofeng Jiang, Ruoxi Hu, Ann C Wu, Jessica A Lasky-Su, Barbara J Klanderman, John Ziniti, Jody Senter-Sylvia, John J Lima, Charles G Irvin, Stephen P Peters, Deborah A Meyers, Eugene R Bleecker, Michiaki Kubo, Mayumi Tamari, Yusuke Nakamura, Stanley J Szefler, Robert F Lemanske, Robert S Zeiger, Robert C Strunk, Fernando D Martinez, John P Hanrahan, Gerard H Koppelman, Dirkje S Postma, Maartje A E Nieuwenhuis, Judith M Vonk, Reynold A Panettieri, Amy Markezich, Elliot Israel, Vincent J Carey, Kelan G Tantisira, Augusto A Litonjua, Quan Lu, Scott T Weiss
Publikováno v:
PLoS Genetics, Vol 8, Iss 7, p e1002824 (2012)
Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV(1)) before and after the administration of a short-acting β(2)-agonist, the most common rescue medi
Externí odkaz:
https://doaj.org/article/92591fe4bdda4b30b783977102051a13
Autor:
Suzanne L. Pollard, John J. Lima, Karina Romero, Carla Tarazona-Meza, Edward Mougey, Katherine Tomaino, Gary Malpartida-Guzmán, Nadia N. Hansel, William Checkley, GASP Study Investigators
Publikováno v:
Asthma Research and Practice, Vol 3, Iss 1, Pp 1-11 (2017)
Abstract Background Prior evidence suggests that vitamin D deficiency may increase the risk of asthma and atopy and impair pulmonary function in children. Methods In this cross-sectional analysis nested in a case-control study, we analyzed serum 25(O
Externí odkaz:
https://doaj.org/article/04a6f4d34f5145c38fa9c0b93f261b02
Publikováno v:
Pediatric allergy, immunology, and pulmonology. 26(1)
Roughly 9% of African-Americans carry 1 copy of the sickle β-globin allele [sickle-cell trait (SCT)]. The sickle allele may affect the host responses in a way that protects against sequelae of malaria. Besides the association with sporadic episodes
Autor:
Loren C. Denlinger, Jerry A. Krishnan, Maria Pino-Yanes, Hengameh Raissy, Wayne J. Morgan, Manuela Cernadas, Michael D. Cabana, Daniel J. Jackson, J. Tod Olin, David Kantor, Julian Solway, Nicole Grossman, Elizabeth J. Ampleford, Jonathan M. Gaffin, Ronina Covar, Corey Cox, Michael E. Wechsler, James F. Chmiel, Elliot Israel, Kathleen C. Barnes, Steven R. White, Lisa Sullivan-Vedder, Stephen C. Lazarus, Fernando Holguin, Gregory A. Hawkins, Anne M. Fitzpatrick, Jason E. Lang, Vernon M. Chinchilli, Harsha Kumar, Jacqueline A. Pongracic, Max A. Seibold, Njira L Lugogo, Esteban G. Burchard, Angel C.Y. Mak, Fernando D. Martinez, Esther Herrera-Luis, Stephen P. Peters, James N. Moy, Lewis J. Smith, Victor E. Ortega, Sachin Baxi, Craig F. LaForce, Perdita Permaul, Marissa Hautpman, John J. Lima, Wanda Phipatanakul, Tarig Ali-Dinar, Michelle Daya, Juan Carlos Cardet, Kristie Ross, Nizar N. Jarjour, Christine A. Sorkness, Celeste Eng, Robert F. Lemanske, Susan J. Kunselman, Monica Kraft, Rachel G. Robison, Stanley J. Szefler, Deborah A. Meyers, Deborah Gentile, Mario Castro, Satria P Sajuthi, Dayna Long, Dave Mauger, Margee Louisias, Elizabeth Burke-Roberts, Donglei Hu, Ross E. Myers, Sally E. Wenzel, Kathryn V. Blake, Avraham Beigelman, Lakeia Wright, Mindy Benson, Leonard B. Bacharier, Eugene R. Bleecker, Wendy C. Moore, Emily DiMango, Loretta Que, Edward T. Naureckas, Lisa Bartnikas, William Sheehan
Publikováno v:
The Lancet. Child & adolescent health, vol 5, iss 12
Lancet Child Adolesc Health
Lancet Child Adolesc Health
BACKGROUND Pharmacogenetic studies in asthma cohorts, primarily made up of White people of European descent, have identified loci associated with response to inhaled beta agonists and corticosteroids (ICSs). Differences exist in how individuals from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34215da576a7d9499f7161c5b4881d4e
https://escholarship.org/uc/item/2x5116nm
https://escholarship.org/uc/item/2x5116nm
Autor:
David T. Mauger, Edward T. Naureckas, Kristie R. Ross, Fernando D. Martinez, Jonathan M. Gaffin, James N. Moy, Ronina A. Covar, Jason E. Lang, John J. Lima, Jane E. Clougherty, Michael E. Wechsler, Leonard B. Bacharier, Jacqueline A. Pongracic, Elliot Israel, Julian Solway, Fernando Holguin, Mario Castro, Wayne J. Morgan, Ellen Kinnee, Michael D. Cabana, Avraham Beigelman, Steven R. White, Kathryn V. Blake, Stephen P. Peters, Lewis J. Smith, Anne M. Fitzpatrick, Jerry A. Krishnan, Victor E. Ortega, Stephen C. Lazarus, Harsha Vardhan Hampasandra Madan Kumar, Deborah A. Gentile, Sally E. Wenzel, Christine A. Sorkness, Wanda Phipatanakul, Monica Kraft, James F Chmiel, Robert F. Lemanske, William J. Sheehan, Juan Carlos Cardet, Ross Myers, Daniel J. Jackson
Publikováno v:
The Lancet. Respiratory Medicine
Autor:
Leonard B. Bacharier, Christopher B. Forrest, Lisa Ulrich, Tim Wysocki, Jobayer Hossain, Matthew Test, Amanda F. Dempsey, John J. Lima, H. Timothy Bunnell, Jason E. Lang
Publikováno v:
Pediatric Pulmonology. 54:1684-1693
Rationale Obesity in children increases the risk for new asthma. How age, sex, race/ethnicity, and allergy status affect the relationship between obesity and asthma is unclear. This study describes the relationship between high body mass index (BMI)
Autor:
Langdon S, John J. Lima, Hossain Mj, Edward B. Mougey, Jason E. Lang, Balagopal Pb, Livingston F
Publikováno v:
Ann Am Thorac Soc
Rationale: Omega-3 fatty acid (n3PUFA) supplementation has been proposed as a promising antiasthma strategy. The rs59439148 ALOX5 polymorphism affects leukotriene production and possibly inflammatory responses to n3PUFA. Objectives: Assess the effect
Autor:
Karina Romero, Gasp Study Investigators, John J. Lima, Suzanne L. Pollard, Nadia N. Hansel, Amanda Pereira, William Checkley, Robert Locke
Publikováno v:
Respiratory Medicine. 145:212-216
Background Asthma prevalence continues to increase in low and middle-income countries, presenting challenges in assessing asthma control in resource-poor settings. Previous studies suggest that exhaled carbon monoxide (eCO) is higher with asthma seve