Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John J Lambourne"'
Autor:
Luigi Grassi, Osagie G. Izuogu, Natasha A.N. Jorge, Denis Seyres, Mariona Bustamante, Frances Burden, Samantha Farrow, Neda Farahi, Fergal J. Martin, Adam Frankish, Jonathan M. Mudge, Myrto Kostadima, Romina Petersen, John J. Lambourne, Sophia Rowlston, Enca Martin-Rendon, Laura Clarke, Kate Downes, Xavier Estivill, Paul Flicek, Joost H.A. Martens, Marie-Laure Yaspo, Hendrik G. Stunnenberg, Willem H. Ouwehand, Fabio Passetti, Ernest Turro, Mattia Frontini
Publikováno v:
Haematologica, Vol 106, Iss 10 (2020)
Transcriptional profiling of hematopoietic cell subpopulations has helped to characterize the developmental stages of the hematopoietic system and the molecular bases of malignant and non-malignant blood diseases. Previously, only the genes targeted
Externí odkaz:
https://doaj.org/article/fc260f918bfb4ac080d707f06026c2c3
Autor:
Oliver S. Burren, Arcadio Rubio García, Biola-Maria Javierre, Daniel B. Rainbow, Jonathan Cairns, Nicholas J. Cooper, John J. Lambourne, Ellen Schofield, Xaquin Castro Dopico, Ricardo C. Ferreira, Richard Coulson, Frances Burden, Sophia P. Rowlston, Kate Downes, Steven W. Wingett, Mattia Frontini, Willem H. Ouwehand, Peter Fraser, Mikhail Spivakov, John A. Todd, Linda S. Wicker, Antony J. Cutler, Chris Wallace
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-19 (2017)
Abstract Background Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates iden
Externí odkaz:
https://doaj.org/article/a2ac010742a3449aa23a667a36cbedcf
Autor:
Romina Petersen, John J. Lambourne, Biola M. Javierre, Luigi Grassi, Roman Kreuzhuber, Dace Ruklisa, Isabel M. Rosa, Ana R. Tomé, Heather Elding, Johanna P. van Geffen, Tao Jiang, Samantha Farrow, Jonathan Cairns, Abeer M. Al-Subaie, Sofie Ashford, Antony Attwood, Joana Batista, Heleen Bouman, Frances Burden, Fizzah A. Choudry, Laura Clarke, Paul Flicek, Stephen F. Garner, Matthias Haimel, Carly Kempster, Vasileios Ladopoulos, An-Sofie Lenaerts, Paulina M. Materek, Harriet McKinney, Stuart Meacham, Daniel Mead, Magdolna Nagy, Christopher J. Penkett, Augusto Rendon, Denis Seyres, Benjamin Sun, Salih Tuna, Marie-Elise van der Weide, Steven W. Wingett, Joost H. Martens, Oliver Stegle, Sylvia Richardson, Ludovic Vallier, David J. Roberts, Kathleen Freson, Lorenz Wernisch, Hendrik G. Stunnenberg, John Danesh, Peter Fraser, Nicole Soranzo, Adam S. Butterworth, Johan W. Heemskerk, Ernest Turro, Mikhail Spivakov, Willem H. Ouwehand, William J. Astle, Kate Downes, Myrto Kostadima, Mattia Frontini
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and p
Externí odkaz:
https://doaj.org/article/2c4a1a97d70840748bc7d87203e84d18
Autor:
Victor M. Tan, Shengkan Jin, Katarzyna M. Tyc, Melany Ruiz-Urigüen, Jennifer A. Harbottle, Ceri M. Wiggins, Juan Collantes, Jinchuan Xing, John J. Lambourne, Hanlin Tao, Chi Su, Amer Alasadi, Jingjing Guo, Huiting Xu, Tommaso Selmi, Jesse Stombaugh
Publikováno v:
CRISPR J
Conventional CRISPR approaches for precision genome editing rely on the introduction of DNA double-strand breaks (DSB) and activation of homology-directed repair (HDR), which is inherently genotoxic and inefficient in somatic cells. The development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b22b5ff1417128252b11da8202ac8a
https://doi.org/10.1089/crispr.2020.0035
https://doi.org/10.1089/crispr.2020.0035
Autor:
Natasha Andressa Nogueira Jorge, Jonathan M. Mudge, Mattia Frontini, Myrto Kostadima, Osagie G. Izuogu, Enca Martin-Rendon, Hendrik G. Stunnenberg, Romina Petersen, Denis Seyres, Xavier Estivill, Paul Flicek, Luigi Grassi, Samantha Farrow, Fabio Passetti, John J. Lambourne, Willem H. Ouwehand, Neda Farahi, Frances Burden, Adam Frankish, Sophia Rowlston, Joost H.A. Martens, Marie-Laure Yaspo, Kate Downes, Mariona Bustamante, Laura Clarke, Ernest Turro, Fergal J. Martin
Publikováno v:
Haematologica
Transcriptional profiling of hematopoietic cell subpopulations has helped to characterize the developmental stages of the hematopoietic system and the molecular bases of malignant and non-malignant blood diseases. Previously, only the genes targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a980f76dbddd9b34e0b2030d7e08cec
Autor:
Harriet McKinney, Leong L. Ng, Maik Pietzner, Simona D'Amore, Julian L. Griffin, Bekir Erguener, Michael Allison, John J Lambourne, Mattia Frontini, Matthew C Sims, Paul D. W. Kirk, Adrian Park, Denis Seyres, Kate Downes, Carly Kempster, Claudia Langenberg, Luigi Grassi, Luca Stefanucci, Frances Burden, Paulenne Quinn, Claire Adams, Albert Koulman, Karola Rehnström, Gabriele Mocciaro, Christoph Bock, Thong Huy Cao, Amy Frary, Samantha Farrow, Roman Kreuzhuber, Michele Vacca, David B. Savage, Oliver Slingsby, Alessandra Cabassi, Joana Batista
Improving the understanding of cardiometabolic syndrome pathophysiology and its relationship with thrombosis are ongoing healthcare challenges. Using plasma biomarkers analysis coupled with the transcriptional and epigenetic characterisation of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3a24582b2e3ff33ceee29b75708073a
https://doi.org/10.1101/2020.03.06.961805
https://doi.org/10.1101/2020.03.06.961805
Autor:
Luigi Grassi, N. A. Jeorge, Kate Downes, Frances Burden, Paul Flicek, Xavier Estivill, John J. Lambourne, Neda Farahi, Henk Stunnenberg, Willem H. Ouwehand, Romina Petersen, Denis Seyres, Fergal J. Martin, Fabio Passetti, Adam Frankish, Sophia Rowlston, Laura Clarke, Joost H.A. Martens, S. Farrow, Myrto Kostadima, Osagie G. Izuogu, Ernest Turro, Marie-Laure Yaspo, Jonathan M. Mudge, Mariona Bustamante, Mattia Frontini, Enca Martin-Rendon
Transcriptional profiling of hematopoietic cell subpopulations has helped characterize the developmental stages of the hematopoietic system and the molecular basis of malignant and non-malignant blood diseases for the past three decades. The introduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7193449f322457c6321bba401e731fa2
Autor:
Ricardo C. Ferreira, Oliver S. Burren, Xaquin Castro Dopico, John J. Lambourne, Kate Downes, Steven W. Wingett, Mikhail Spivakov, Daniel B. Rainbow, Antony J. Cutler, Ellen Schofield, Linda S. Wicker, Nicholas J. Cooper, Jonathan Cairns, Frances Burden, Richard M.R. Coulson, Mattia Frontini, John A. Todd, Sophia Rowlston, Chris Wallace, Biola-Maria Javierre, Willem H. Ouwehand, Arcadio Rubio García, Peter Fraser
Publikováno v:
Genome Biology
Genome Biology, Vol 18, Iss 1, Pp 1-19 (2017)
Genome Biology, Vol 18, Iss 1, Pp 1-19 (2017)
BackgroundAutoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8698d7c3690bcc8cf542556058da2dd4
https://pubmed.ncbi.nlm.nih.gov/28870212
https://pubmed.ncbi.nlm.nih.gov/28870212
Autor:
Alexander M. Morin, Chuan He, Miao Yu, Julia L. MacIsaac, Anne Danckaert, Athma A. Pai, Roger Pique-Regi, Jean-Christophe Grenier, Kasper D. Hansen, Francesca Luca, Tomi Pastinen, Michael S. Kobor, Ludovic Tailleux, Anne Dumaine, Yoav Gilad, John J. Lambourne, Brigitte Gicquel, Vania Yotova, Luis B. Barreiro, Jenny Tung, Alain Pacis
Publikováno v:
Genome Research
Genome Research, 2015, 25 (12), pp.1801-1811. ⟨10.1101/gr.192005.115⟩
Cold Spring Harbor Laboratory Press
Genome Research, 2015, 25 (12), pp.1801-1811. ⟨10.1101/gr.192005.115⟩
Cold Spring Harbor Laboratory Press
DNA methylation is an epigenetic mark thought to be robust to environmental perturbations on a short time scale. Here, we challenge that view by demonstrating that the infection of human dendritic cells (DCs) with a live pathogenic bacteria is associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e84899e694c2e74d0022a3f735442b
https://hal-pasteur.archives-ouvertes.fr/pasteur-03525486/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03525486/document
Autor:
Anne Dumaine, John J. Lambourne, Vania Yotova, Roger Pique-Regi, Ludovic Tailleux, Luis B. Barreiro, Brigitte Gicquel, Jenny Tung, Kasper D. Hansen, Jean-Christophe Grenier, Francesca Luca, Tomi Pastinen, Yoav Gilad, Athma A. Pai, Chuan He, Alain Pacis, Anne Danckaert, Miao Yu
DNA methylation is thought to be robust to environmental perturbations on a short time scale. Here, we challenge that view by demonstrating that the infection of human dendritic cells (DCs) with a pathogenic bacteria is associated with rapid changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0df72ba53dcdb103a8ba5e1b2253b2d
https://doi.org/10.1101/016022
https://doi.org/10.1101/016022