Zobrazeno 1 - 10
of 35
pro vyhledávání: '"John J L, Jacobs"'
Autor:
Annemie M W J Schols, Anke H Maitland-van der Zee, Joop P van den Bergh, Sebastiaan Holverda, Esther J Nossent, Els J M Weersink, Marianne A van de Pol, Firdaus A A Mohamed Hoesein, Lisanne T Schuurman, Ivo van der Lee, Jelle M Blankestijn, Mahmoud I Abdel-Aziz, Nadia Baalbaki, Somayeh Bazdar, Inés Beekers, Rosanne J H C G Beijers, Lizan D Bloemsma, Merel E B Cornelissen, Debbie Gach, Laura Houweling, John J L Jacobs, Reneé Jonker, Paulien M A Linders, Lieke C E Noij, Daphne W Schaminee, Brigitte Sondermeijer, J J Miranda Geelhoed, Yolanda de Wit-van Wijck
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background Four months after SARS-CoV-2 infection, 22%–50% of COVID-19 patients still experience complaints. Long COVID is a heterogeneous disease and finding subtypes could aid in optimising and developing treatment for the individual patient.Meth
Externí odkaz:
https://doaj.org/article/08cab7016402442e9e9b869081c263bd
Autor:
Daria Shevtsova, Anam Ahmed, Iris W A Boot, Carmen Sanges, Michael Hudecek, John J L Jacobs, Simon Hort, Hubertus J M Vrijhoef
Publikováno v:
JMIR Human Factors, Vol 11, p e47031 (2024)
BackgroundArtificial intelligence (AI)–powered technologies are being increasingly used in almost all fields, including medicine. However, to successfully implement medical AI applications, ensuring trust and acceptance toward such technologies is
Externí odkaz:
https://doaj.org/article/dbd626d0294048c38dce54fea962e7ca
Autor:
Niklas Bäckel, Simon Hort, Tamás Kis, David F. Nettleton, Joseph R. Egan, John J. L. Jacobs, Dennis Grunert, Robert H. Schmitt
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
This paper discusses the challenges of producing CAR-T cells for cancer treatment and the potential for Artificial Intelligence (AI) for its improvement. CAR-T cell therapy was approved in 2018 as the first Advanced Therapy Medicinal Product (ATMP) f
Externí odkaz:
https://doaj.org/article/91bf0e4959f147c7939554fa0cf7814f
Autor:
Simon Hort, Laura Herbst, Niklas Bäckel, Frederik Erkens, Bastian Niessing, Maik Frye, Niels König, Ioannis Papantoniou, Michael Hudecek, John J. L. Jacobs, Robert H. Schmitt
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
CAR-T cell therapy is a promising treatment for acute leukemia and lymphoma. CAR-T cell therapies take a pioneering role in autologous gene therapy with three EMA-approved products. However, the chance of clinical success remains relatively low as th
Externí odkaz:
https://doaj.org/article/9bb8ea8db6534f5982f371b47e1dbc02
Autor:
Willem Den Otter, Dainius Characiejus, Vita Paukonien, Mykolas Mauricas, R. Jeroen A. van Moorselaar, John J. L. Jacobs, Feliksas Jankeviius
Publikováno v:
The Open Cancer Immunology Journal. 3:8-14
Immunotherapy with BCG is effective in patients with recurrent superficial bladder carcinoma. This therapy involves Interleukin-2 (IL-2), but little is known about the immunological parameters involved in superficial bladder carcinoma. We have monito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0039ce3a5a53d2eca969ff267941ceb
https://doi.org/10.2174/1876401001003010008
https://doi.org/10.2174/1876401001003010008
Autor:
Jan Willem Koten, R. J. E. Stewart, Willem Den Otter, Ekaterina V. Moiseeva, John J. L. Jacobs, Paul G. P. M. Ziekman, Gerrit Jan Hordijk, Zachary Krastev, Jan J. Battermann
Publikováno v:
Cancer Immunology, Immunotherapy
This is a position paper about the therapeutic effects of locally applied free IL-2 in the treatment of cancer. Local therapy: IL-2 therapy of cancer was originally introduced as a systemic therapy. This therapy led to about 20% objective responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98eb5757d85f83a36382cba4a74d5a15
https://doi.org/10.1007/s00262-008-0455-z
https://doi.org/10.1007/s00262-008-0455-z
Autor:
Willem, DEN Otter, Margot, Hack, John J L, Jacobs, Jurgen F V, Tan, Lawrence, Rozendaal, R Jeroen A, VAN Moorselaar
Publikováno v:
Anticancer research. 35(6)
To improve treatment of inoperable transmissible venereal tumors (TVTs) in dogs. Recently, we showed that TVT is sensitive to intratumoral treatment with interleukin-2 (IL2). In addition it is known that TVT is sensitive to intravenous treatment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::767904e83e8f95b498868547e8fb4298
https://pubmed.ncbi.nlm.nih.gov/26026099
https://pubmed.ncbi.nlm.nih.gov/26026099
Autor:
Willem, Den Otter, Margot, Hack, John J L, Jacobs, Jurgen F V, Tan, Lawrence, Rozendaal, R Jeroen A, Van Moorselaar
Publikováno v:
Anticancer research. 35(2)
To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2).We treated 13 dogs with 18 natural TVTs with IL-2. The tumors were treated with intratumoral application of 2×10(6) units I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdedaaa075af2bd902cc8c9f89b55777
https://pubmed.ncbi.nlm.nih.gov/25667450
https://pubmed.ncbi.nlm.nih.gov/25667450
Autor:
Agnieszka Masztalerz, R. J. E. Stewart, W. K. den Otter, John J. L. Jacobs, F. W. G. Hill, J. W. Koten
Publikováno v:
Veterinary Record. 159:668-672
In total, 174 bovine ocular squamous cell carcinomas of varying sizes (20 to 2800 mm(2) in area) were treated daily with peritumoural injections of solvent, or solvent containing 5000 U, 20,000 U, 200,000 U, 500,000 U, 1 million U or 2 million U inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb05f2c17b1e5ed0e4fe15f46cd5d074
https://doi.org/10.1136/vr.159.20.668
https://doi.org/10.1136/vr.159.20.668
Publikováno v:
Experimental dermatology, 15(6), 432-440. Wiley-Blackwell
Skin irritants and contact allergens reduce the number of Langerhans cells (LCs). It has been assumed that this reduction is due their migration to the draining lymph node (LN) for initiating immune sensitization in a host. Skin irritation, however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3415faab529a2d7a0bd30c9252a96109
https://doi.org/10.1111/j.0906-6705.2006.00420.x
https://doi.org/10.1111/j.0906-6705.2006.00420.x