Zobrazeno 1 - 10
of 27
pro vyhledávání: '"John J G, Tesmer"'
Autor:
Madison F Walker, Jingyi Zhang, William Steiner, Pei-I Ku, Ju-Fen Zhu, Zachary Michaelson, Yu-Chen Yen, Annabel Lee, Alyssa B Long, Mattie J Casey, Abhishek Poddar, Isaac B Nelson, Corvin D Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M Kwan, Stefan Schulz, Rodney A Stewart, John J G Tesmer, Tamara Caspary, Radhika Subramanian, Xuecai Ge, Benjamin R Myers
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002685 (2024)
During Hedgehog (Hh) signal transduction in development and disease, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by binding the protein kinase A catalytic subunit (PKA-C) and physically
Externí odkaz:
https://doaj.org/article/dd4df563bde8484e9cf388d6a8c3f333
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
G protein-coupled receptor (GPCR) kinase 2 (GRK2), which phosphorylates agonist-occupied GPCRs to promote their desensitization, has been investigated as an attractive therapeutic target for cardiovascular and metabolic diseases. Several GRK2-targete
Externí odkaz:
https://doaj.org/article/26fc1329f9ae43bcada9a57b6be7c3cc
Autor:
Madison F. Walker, Jingyi Zhang, William Steiner, Pei-I Ku, Ju-Fen Zhu, Zachary Michaelson, Yu-Chen Yen, Alyssa B. Long, Mattie J. Casey, Abhishek Poddar, Isaac B. Nelson, Corvin D. Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M. Kwan, Stefan Schulz, Rodney A. Stewart, John J. G. Tesmer, Tamara Caspary, Radhika Subramanian, Xuecai Ge, Benjamin R. Myers
Publikováno v:
bioRxiv
During Hedgehog (Hh) signal transduction in development, homeostasis, and cancer, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by directly binding the PKA catalytic subunit (PKA-C) and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f849ab21c1dc2a9f085f18f5c84fc5
https://doi.org/10.1101/2023.05.10.540226
https://doi.org/10.1101/2023.05.10.540226
Autor:
Chun-Liang Chen, Ramizah Syahirah, Sandeep K. Ravala, Yu-Chen Yen, Thomas Klose, Qing Deng, John J. G. Tesmer
Publikováno v:
bioRxiv
The conversion of PIP2 to PIP3 by phosphoinositide 3-kinase γ (PI3Kγ) is a critical step in neutrophil chemotaxis and is essential for metastasis in many types of cancer. PI3Kγ is activated via directed interaction with Gβγ heterodimers released
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51aefac6658a82e306d7578e8c3cf301
https://doi.org/10.1101/2023.05.04.539492
https://doi.org/10.1101/2023.05.04.539492
Autor:
Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J Watts, Carmen W Dessauer, John J. G. Tesmer
Publikováno v:
bioRxiv
The nine different membrane-anchored adenylyl cyclase isoforms (AC1-9) in mammals are stimulated by the heterotrimeric G protein Gαs, but their response to Gβγ regulation is isoform-specific. For example, AC5 is conditionally activated by Gβγ. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bba0a21f572f2aa99392d5e7f705b7
https://doi.org/10.1101/2023.05.02.539090
https://doi.org/10.1101/2023.05.02.539090
Autor:
M. Claire Cato, Yu-Chen Yen, Charnelle J. Francis, Kaely E. Elkins, Afzaal Shareef, Rachel Sterne-Marr, John J. G. Tesmer
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 447 (2021)
G protein-coupled receptors (GPCRs), which regulate a vast number of eukaryotic processes, are desensitized by various mechanisms but, most importantly, by the GPCR kinases (GRKs). Ever since GRKs were first identified, investigators have sought to d
Externí odkaz:
https://doaj.org/article/508ef251ec474ab68688bf3ebddf44fa
Publikováno v:
bioRxiv
Atypical chemokine receptor 3 (ACKR3) is an arrestin-biased receptor that regulates extracellular chemokine levels through scavenging. The scavenging action mediates the availability of the chemokine CXCL12 for the G protein-coupled receptor (GPCR) C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676638fcf1095a466d9f3d5af5fad1c1
https://europepmc.org/articles/PMC9980177/
https://europepmc.org/articles/PMC9980177/
Autor:
Kira Vanessa Blankenbach, Ralf Frederik Claas, Natalie Judith Aster, Anna Katharina Spohner, Sandra Trautmann, Nerea Ferreirós, Justin L. Black, John J. G. Tesmer, Stefan Offermanns, Thomas Wieland, Dagmar Meyer zu Heringdorf
Publikováno v:
Cells, Vol 9, Iss 10, p 2201 (2020)
Diverse extracellular signals induce plasma membrane translocation of sphingosine kinase-1 (SphK1), thereby enabling inside-out signaling of sphingosine-1-phosphate. We have shown before that Gq-coupled receptors and constitutively active Gαq/11 spe
Externí odkaz:
https://doaj.org/article/f549208b4be8498faf967cdaab7c6069
Autor:
Yu-Chen Yen, Christopher T. Schafer, Martin Gustavsson, Stefanie A. Eberle, Pawel K. Dominik, Dawid Deneka, Penglie Zhang, Thomas J. Schall, Anthony A. Kossiakoff, John J. G. Tesmer, Tracy M. Handel
Publikováno v:
Yen, Y-C, Schafer, C T, Gustavsson, M, Eberle, S A, Dominik, P K, Deneka, D, Zhang, P, Schall, T J, Kossiakoff, A A, Tesmer, J J G & Handel, T M 2022, ' Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias ', Science advances, vol. 8, no. 28, eabn8063 . https://doi.org/10.1126/sciadv.abn8063
Yen, Y C, Schafer, C T, Gustavsson, M, Eberle, S A, Dominik, P K, Deneka, D, Zhang, P, Schall, T J, Kossiakoff, A A, Tesmer, J J G & Handel, T M 2022, ' Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias ', Science Advances, vol. 8, no. 28, eabn8063 . https://doi.org/10.1126/sciadv.abn8063
Yen, Y C, Schafer, C T, Gustavsson, M, Eberle, S A, Dominik, P K, Deneka, D, Zhang, P, Schall, T J, Kossiakoff, A A, Tesmer, J J G & Handel, T M 2022, ' Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias ', Science Advances, vol. 8, no. 28, eabn8063 . https://doi.org/10.1126/sciadv.abn8063
Both CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are activated by the chemokine CXCL12 yet evoke distinct cellular responses. CXCR4 is a canonical G protein–coupled receptor (GPCR), whereas ACKR3 is intrinsically bias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924a40f0f550a39a13d9bb38b5bfa45b
https://hdl.handle.net/1871.1/baa45b22-f1c8-4c16-9abe-4570a7bcd739
https://hdl.handle.net/1871.1/baa45b22-f1c8-4c16-9abe-4570a7bcd739
Publikováno v:
Molecules, Vol 19, Iss 10, Pp 16937-16949 (2014)
G protein-coupled receptor kinases (GRKs) have been implicated in human diseases ranging from heart failure to diabetes. Previous studies have identified several compounds that selectively inhibit GRK2, such as paroxetine and balanol. Far fewer selec
Externí odkaz:
https://doaj.org/article/2033a9864a144175bf8b70ccff2b629f