Zobrazeno 1 - 10
of 14
pro vyhledávání: '"John J Emmins"'
Autor:
Michael J Hickey, Rain Y Q Kwan, Milena M Awad, Catherine L Kennedy, Lauren F Young, Pam Hall, Leanne M Cordner, Dena Lyras, John J Emmins, Julian I Rood
Publikováno v:
PLoS Pathogens, Vol 4, Iss 4, p e1000045 (2008)
Reduced tissue perfusion leading to tissue ischemia is a central component of the pathogenesis of myonecrosis caused by Clostridium perfringens. The C. perfringens alpha-toxin has been shown capable of inducing these changes, but its potential synerg
Externí odkaz:
https://doaj.org/article/b20197b5218e4ca4ace2e83cf9b275b5
Autor:
John J. Emmins, Julian I. Rood, Leanne M Cordner, Dena Lyras, Rodney K. Tweten, Catherine Kennedy, Jody A. Melton-Witt
Publikováno v:
Infection and Immunity. 77:943-951
Clostridium septicum alpha-toxin is a β-barrel pore-forming cytolysin that is functionally similar to aerolysin. Residues important in receptor binding, oligomerization, and pore formation have been identified; however, little is known about the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b24b431bb0868c09da11e9cda11fd5
https://doi.org/10.1128/iai.01267-08
https://doi.org/10.1128/iai.01267-08
Autor:
Catherine Kennedy, Jackie K. Cheung, Julian I. Rood, John J. Emmins, Thomas J. Hiscox, Dena Lyras
Publikováno v:
Microbes and Infection. 11:413-418
Clostridium perfringens and Clostridium septicum are the most common causes of clostridial myonecrosis or gas gangrene. Although they mediate a similar disease pathology, they elaborate functionally very different alpha-toxins. We used a reciprocal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d01a78d5c363f946c82db4188b38e5
https://doi.org/10.1016/j.micinf.2009.01.002
https://doi.org/10.1016/j.micinf.2009.01.002
Autor:
John J. Emmins, Andrew G. D. Bean, David G Strom, Terri E. O’Neil, Marion Elizabeth Andrew, Kirsten R. Morris, Mary M. Broadway, Matthew P. Bruce
Publikováno v:
Journal of Interferon & Cytokine Research. 28:435-444
Increasing resistance to anthelmintic drugs indicates a vital need to develop alternative strategies to control helminth infections. Interleukin-3 (IL-3) is a multilineage hematopoietic growth regulator produced by activated T lymphocytes in response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e13cb08a384b789ef5beb6d08711d3
https://doi.org/10.1089/jir.2007.0051
https://doi.org/10.1089/jir.2007.0051
Autor:
Dena Lyras, Efrosinia O Krejany, Jennifer Ruth O'Connor, John J. Emmins, Lauren Florence Young, Richard L. Boyd, Milena M. Awad, Catherine Kennedy, Julian I. Rood
Publikováno v:
Molecular Microbiology. 57:1357-1366
Clostridium septicum is the causative agent of spontaneous gas gangrene or atraumatic myonecrosis, a sudden and frequently fatal infection that is increasingly associated with malignancy of the colon. Little is known about the disease process althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f19699db0735614aeb1408b14393f25
https://doi.org/10.1111/j.1365-2958.2005.04774.x
https://doi.org/10.1111/j.1365-2958.2005.04774.x
Publikováno v:
Infection and Immunity. 69:7904-7910
To examine the synergistic effects of alpha-toxin and perfringolysin O in clostridial myonecrosis, homologous recombination was used to construct an alpha-toxin deficient derivative of a perfringolysin O mutant of Clostridium perfringens . The subseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004d09b2041012e43fdd3d1a161563b1
https://doi.org/10.1128/iai.69.12.7904-7910.2001
https://doi.org/10.1128/iai.69.12.7904-7910.2001
Autor:
Amy E. Bryant, Richard L. Boyd, John J. Emmins, Osamu Matsushita, Dennis L. Stevens, Julian I. Rood, Darren M. Ellemor, Milena M. Awad
Publikováno v:
Microbial Pathogenesis. 28:107-117
Clostridium perfringens produces several extracellular toxins and enzymes, including an extracellular collagenase or κ toxin that is encoded by the colA gene. To determine if the ability to produce collagenase was a significant virulence factor in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2748c2a436cec911c8aeb887e13b03f5
https://doi.org/10.1006/mpat.1999.0328
https://doi.org/10.1006/mpat.1999.0328
Autor:
Darren M. Ellemor, Milena M. Awad, John J. Emmins, Julian I. Rood, Rebecca N. Baird, Richard L. Boyd
Publikováno v:
Monash University
A hallmark of gas gangrene (clostridial myonecrosis) pathology is a paucity of leukocytes infiltrating the necrotic tissue. The cause of this paucity most likely relates to the observation of leukocyte aggregates at the border of the area of tissue n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3026915d7bc00d5863d7a3e22a2b446f
https://doi.org/10.1128/iai.67.9.4902-4907.1999
https://doi.org/10.1128/iai.67.9.4902-4907.1999
Autor:
Marietta Flores-Díaz, John J. Emmins, Sacha J. Pidot, Meredith Lesley Hughes, Milena M. Awad, Martina Chiarezza, Rachael Poon, Julian I. Rood, Alberto Alape-Girón, Leanne M Cordner, Catherine Kennedy, Tongted Phumoonna, Dena Lyras
The essential toxin in Clostridium perfringens -mediated gas gangrene or clostridial myonecrosis is alpha-toxin, although other toxins and extracellular enzymes may also be involved. In many bacterial pathogens extracellular sialidases are important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb691ccd1f6be92e64f1fdef1b2a7dd
https://europepmc.org/articles/PMC2747931/
https://europepmc.org/articles/PMC2747931/
Autor:
Catherine L, Kennedy, Efrosinia O, Krejany, Lauren F, Young, Jennifer R, O'Connor, Milena M, Awad, Richard L, Boyd, John J, Emmins, Dena, Lyras, Julian I, Rood
Publikováno v:
Molecular microbiology. 57(5)
Clostridium septicum is the causative agent of spontaneous gas gangrene or atraumatic myonecrosis, a sudden and frequently fatal infection that is increasingly associated with malignancy of the colon. Little is known about the disease process althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a598ac6dd211382c13e9886780fbcbdf
https://pubmed.ncbi.nlm.nih.gov/16102005
https://pubmed.ncbi.nlm.nih.gov/16102005