Zobrazeno 1 - 10
of 83
pro vyhledávání: '"John J Cole"'
Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis
Autor:
Katja Thümmler, Mark TS Williams, Susan Kitson, Shatakshi Sood, Moeed Akbar, John J Cole, Ewan Hunter, Richard Soutar, Carl S Goodyear
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Bone disease represents a major cause of morbidity and mortality in Multiple Myeloma (MM); primarily driven by osteoclasts whose differentiation is dependent on expression of RANKL by MM cells. Notably, costimulation by ITAM containing receptors (i.e
Externí odkaz:
https://doaj.org/article/518434438e734c349b793593c41a7875
Autor:
Melissa Kießling, John J. Cole, Sabrina Kübel, Paulina Klein, Klaus Korn, Amy R. Henry, Farida Laboune, Slim Fourati, Ellen Harrer, Thomas Harrer, Daniel C. Douek, Klaus Überla, Krystelle Nganou-Makamdop
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract To date, our understanding of how HIV infection impacts vaccine-induced cellular immunity is limited. Here, we investigate inflammation, immune activation and antigen-specific T cell responses in HIV-uninfected and antiretroviral-treated HIV
Externí odkaz:
https://doaj.org/article/6b135f377b7447ceade9761346a3e5d1
Autor:
Sabha Asghar, Gary J. Litherland, John J. Cole, Iain B. McInnes, R. M. D. Meek, John C. Lockhart, Carl S. Goodyear, Anne Crilly
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis (OA). However, a comprehensive evaluation using disease relevant cells
Externí odkaz:
https://doaj.org/article/3b5cf59e34534e7c8772f11be34ab22f
Publikováno v:
International Journal of Translational Medicine, Vol 4, Iss 2, Pp 354-368 (2024)
Tyrosine kinase inhibitors (TKIs), such as imatinib (IM), increase the survival of chronic myeloid leukemia (CML) patients but do not eradicate the disease as leukemia stem cells (LSCs) with primitive and quiescent signatures persist after TKI monoth
Externí odkaz:
https://doaj.org/article/7634c85c657d4850b5341db0698fea94
Autor:
John J. Cole, Neil A. Robertson, Mohammed Iqbal Rather, John P. Thomson, Tony McBryan, Duncan Sproul, Tina Wang, Claire Brock, William Clark, Trey Ideker, Richard R. Meehan, Richard A. Miller, Holly M. Brown-Borg, Peter D. Adams
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging “clock”, a robust biomarker of aging. However, while genetic, dietary and drug interventions
Externí odkaz:
https://doaj.org/article/9e5c8d1b58dc4f46b45aaefafe9077fd
Autor:
Dina Dikovskaya, John J. Cole, Susan M. Mason, Colin Nixon, Saadia A. Karim, Lynn McGarry, William Clark, Rachael N. Hewitt, Morgan A. Sammons, Jiajun Zhu, Dimitris Athineos, Joshua D.G. Leach, Francesco Marchesi, John van Tuyn, Stephen W. Tait, Claire Brock, Jennifer P. Morton, Hong Wu, Shelley L. Berger, Karen Blyth, Peter D. Adams
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1483-1496 (2015)
Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown. Here, we show that multinu
Externí odkaz:
https://doaj.org/article/8190b7e118b64afbb59c9882cf92b89b
Autor:
John J. Cole, C Ansalone, Sabarinadh Chilaka, Jamie Robertson, Flavia Sunzini, Stefan Siebert, Iain B. McInnes, Carl S. Goodyear, Shatakshi Sood
Publikováno v:
Annals of the Rheumatic Diseases
Objectives Circulating myeloid precursors are responsible for post-natal osteoclast (OC) differentiation and skeletal health, although the exact human precursors have not been defined. Enhanced osteoclastogenesis contributes to joint destruction in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb8463245b605a661db1ee8f7321a1f
http://europepmc.org/articles/PMC8142443
http://europepmc.org/articles/PMC8142443
Autor:
Masaru Suzuki, John J. Cole, Satoshi Konno, Hironi Makita, Hiroki Kimura, Masaharu Nishimura, Rose A. Maciewicz
Publikováno v:
Clinical and Translational Allergy, Vol 11, Iss 10, Pp n/a-n/a (2021)
Clinical and Translational Allergy
Clinical and Translational Allergy
Background Chronic airway diseases including chronic obstructive pulmonary disease (COPD) and asthma are heterogenous in nature and endotypes within are underpinned by complex biology. This study aimed to investigate the utility of proteomic profilin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5436dad91588def0b6feb75c61ee4bfc
https://doaj.org/article/350d910b3ad24cb48ea7afa0a21f259d
https://doaj.org/article/350d910b3ad24cb48ea7afa0a21f259d
PMO-1 Identification of a novel colonic macrophage signature in a subset of Crohn’s disease patients
Autor:
Hannah M Baer, Muhammad I. Khan, Robert Bj Nibbs, Umer I Zeeshan, S Milling, Elizabeth McDonald, John J. Cole, Meera Ramanujam
Publikováno v:
Posters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b94263bcb8f9ea7a166e3a28e437ab7c
https://doi.org/10.1136/gutjnl-2021-bsg.140
https://doi.org/10.1136/gutjnl-2021-bsg.140
Autor:
Domenico Somma, John J. Cole, Kai Ling Liang, Ruaidhrí J. Carmody, Emma L. Smith, Patrick A. Kiely, Zoe McIntyre, Karen Keeshan, David Kerrigan
Publikováno v:
Nucleic Acids Research
Phosphorylation of the NF-κB transcription factor is an important regulatory mechanism for the control of transcription. Here we identify serine 80 (S80) as a phosphorylation site on the p50 subunit of NF-κB, and IKKβ as a p50 kinase. Transcriptom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc779d042024f08bb0faf3ce2348b5b
http://europepmc.org/articles/PMC6868378
http://europepmc.org/articles/PMC6868378