Zobrazeno 1 - 10
of 106
pro vyhledávání: '"John J Cole"'
Autor:
Melissa Kießling, John J. Cole, Sabrina Kübel, Paulina Klein, Klaus Korn, Amy R. Henry, Farida Laboune, Slim Fourati, Ellen Harrer, Thomas Harrer, Daniel C. Douek, Klaus Überla, Krystelle Nganou-Makamdop
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract To date, our understanding of how HIV infection impacts vaccine-induced cellular immunity is limited. Here, we investigate inflammation, immune activation and antigen-specific T cell responses in HIV-uninfected and antiretroviral-treated HIV
Externí odkaz:
https://doaj.org/article/6b135f377b7447ceade9761346a3e5d1
Autor:
Sabha Asghar, Gary J. Litherland, John J. Cole, Iain B. McInnes, R. M. D. Meek, John C. Lockhart, Carl S. Goodyear, Anne Crilly
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis (OA). However, a comprehensive evaluation using disease relevant cells
Externí odkaz:
https://doaj.org/article/3b5cf59e34534e7c8772f11be34ab22f
Publikováno v:
International Journal of Translational Medicine, Vol 4, Iss 2, Pp 354-368 (2024)
Tyrosine kinase inhibitors (TKIs), such as imatinib (IM), increase the survival of chronic myeloid leukemia (CML) patients but do not eradicate the disease as leukemia stem cells (LSCs) with primitive and quiescent signatures persist after TKI monoth
Externí odkaz:
https://doaj.org/article/7634c85c657d4850b5341db0698fea94
Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis
Autor:
Katja Thümmler, Mark TS Williams, Susan Kitson, Shatakshi Sood, Moeed Akbar, John J Cole, Ewan Hunter, Richard Soutar, Carl S Goodyear
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Bone disease represents a major cause of morbidity and mortality in Multiple Myeloma (MM); primarily driven by osteoclasts whose differentiation is dependent on expression of RANKL by MM cells. Notably, costimulation by ITAM containing receptors (i.e
Externí odkaz:
https://doaj.org/article/518434438e734c349b793593c41a7875
Autor:
John J. Cole, Bekir A. Faydaci, David McGuinness, Robin Shaw, Rose A. Maciewicz, Neil A. Robertson, Carl S. Goodyear
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Once bulk RNA-seq data has been processed, i.e. aligned and then expression and differential tables generated, there remains the essential process where the biology is explored, visualized and interpreted. Without the use of a vis
Externí odkaz:
https://doaj.org/article/9bca106272ef4240bc9afd063a856c67
Autor:
John J. Cole, Alison McColl, Robin Shaw, Mary-Ellen Lynall, Philip J. Cowen, Peter de Boer, Wayne C. Drevets, Neil Harrison, Carmine Pariante, Linda Pointon, NIMA consortium, Carl Goodyear, Edward Bullmore, Jonathan Cavanagh
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation forthe variance in this heterogeneous condition. Peripheral blood measures of cytoki
Externí odkaz:
https://doaj.org/article/4f30ee2b03a34839b646dd4197288e34
Autor:
Catriona T. Prendergast, Robert A. Benson, Hannah E. Scales, Caio Santos Bonilha, John J. Cole, Iain McInnes, James M. Brewer, Paul Garside
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Mechanisms governing entry and exit of immune cells into and out of inflamed joints remain poorly understood. We sought herein to identify the key molecular pathways regulating such migration. Using murine models of inflammation in conjunction with m
Externí odkaz:
https://doaj.org/article/5d1175430835444c926fbbd904727585
Autor:
Masaru Suzuki, John J. Cole, Satoshi Konno, Hironi Makita, Hiroki Kimura, Masaharu Nishimura, Rose A. Maciewicz
Publikováno v:
Clinical and Translational Allergy, Vol 11, Iss 10, Pp n/a-n/a (2021)
Abstract Background Chronic airway diseases including chronic obstructive pulmonary disease (COPD) and asthma are heterogenous in nature and endotypes within are underpinned by complex biology. This study aimed to investigate the utility of proteomic
Externí odkaz:
https://doaj.org/article/350d910b3ad24cb48ea7afa0a21f259d
Autor:
Katja Thümmler, Eran Rom, Thomas Zeis, Maren Lindner, Sarah Brunner, John J. Cole, Diana Arseni, Steve Mücklisch, Julia M. Edgar, Nicole Schaeren-Wiemers, Avner Yayon, Christopher Linington
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Fibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple sclerosis, but targeting this therapeutically is complicated by its functional pleiotropy. We now identify FGF2 as a factor up-regulated by astrocyt
Externí odkaz:
https://doaj.org/article/7ee1fa64b1394a10aeb801926f69e36f
Autor:
John J. Cole, Neil A. Robertson, Mohammed Iqbal Rather, John P. Thomson, Tony McBryan, Duncan Sproul, Tina Wang, Claire Brock, William Clark, Trey Ideker, Richard R. Meehan, Richard A. Miller, Holly M. Brown-Borg, Peter D. Adams
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-16 (2017)
Abstract Background Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging “clock”, a robust biomarker of aging. However, while genetic, dietary and drug interventions
Externí odkaz:
https://doaj.org/article/9e5c8d1b58dc4f46b45aaefafe9077fd