Zobrazeno 1 - 10
of 193
pro vyhledávání: '"John J Bissler"'
Autor:
John J Bissler, Norio Nonomura, Klemens Budde, Bernard A Zonnenberg, Michael Fischereder, Maurizio Voi, Anne-Laure Louveau, Fabian Herbst, E Martina Bebin, Paolo Curatolo, Andrea Zonta, Elena Belousova
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0201005 (2018)
INTRODUCTION:The EXIST-2 (NCT00790400) study demonstrated the superiority of everolimus over placebo for the treatment of renal angiomyolipomas associated with tuberous sclerosis complex (TSC) or sporadic lymphangioleiomyomatosis (LAM). This post hoc
Externí odkaz:
https://doaj.org/article/be8e75a4b29844edb0b037d267a772b4
Autor:
Steven Sparagana, David N Franz, Darcy A Krueger, John J Bissler, Noah Berkowitz, Karin Burock, J Christopher Kingswood
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186235 (2017)
To determine the impact of everolimus on female fertility, including menstrual irregularities, secondary amenorrhea, and luteinizing and follicle stimulating hormone levels in female patients.A pooled analysis from 3 prospective studies consisting of
Externí odkaz:
https://doaj.org/article/6aac383e5ef941a9bb987146b6000040
Autor:
John J Bissler, J Chris Kingswood, Elzbieta Radzikowska, Bernard A Zonnenberg, Elena Belousova, Michael D Frost, Matthias Sauter, Susanne Brakemeier, Petrus J de Vries, Noah Berkowitz, Maurizio Voi, Severine Peyrard, Klemens Budde
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0180939 (2017)
We examined the long-term effects of everolimus in patients with renal angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.Following favorable results from the double-blind core phase of EXIST-2 (NCT00790400
Externí odkaz:
https://doaj.org/article/adb7a1c8a2244a96b11096a9f9d07b28
Publikováno v:
Brazilian Journal of Nephrology, Vol 46, Iss 3 (2024)
Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by the development of hamartomas in the central nervous system, heart, skin, lungs, and kidneys and other manifestations including seizures, cortical tubers, rad
Externí odkaz:
https://doaj.org/article/14fb630815e949d59e576ade54b0b873
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16595 (2011)
Children with complex urogenital anomalies often require bladder reconstruction. Gastrointestinal tissues used in bladder augmentations exhibit a greatly increased risk of malignancy, and the bladder microenvironment may play a role in this carcinoge
Externí odkaz:
https://doaj.org/article/464cdffd248c45b7bfedf7ec0aa5d4ba
Autor:
Prashant Kumar, Fahad Zadjali, Ying Yao, Daniel Johnson, Brian Siroky, Aristotelis Astrinidis, Peter Vogel, Kenneth W. Gross, John J. Bissler
Publikováno v:
Genes and Diseases, Vol 9, Iss 1, Pp 187-200 (2022)
TSC renal cystic disease is poorly understood and has no approved treatment. In a new principal cell-targeted murine model of Tsc cystic disease, the renal cystic epithelium is mostly composed of type A intercalated cells with an intact Tsc2 gene con
Externí odkaz:
https://doaj.org/article/e9af695b73a243cab858e93e553b7277
Publikováno v:
Biology, Vol 12, Iss 9, p 1178 (2023)
Extracellular vesicles (EVs) are lipid membrane bound-cell-derived structures that are a key player in intercellular communication and facilitate numerous cellular functions such as tumor growth, metastasis, immunosuppression, and angiogenesis. They
Externí odkaz:
https://doaj.org/article/d46f74bf38a043d5a68cf59dd3aa47d2
Autor:
Prashant Kumar, Fahad Zadjali, Ying Yao, Brian Siroky, Aristotelis Astrinidis, Kenneth W. Gross, John J. Bissler
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
In tuberous sclerosis complex (TSC), Tsc2 mutations are associated with more severe disease manifestations than Tsc1 mutations and the role of extracellular vesicles (EVs) in this context is not yet studied. We report a comparative analysis of EVs de
Externí odkaz:
https://doaj.org/article/cfd84fb97743434386200feaede95852
Autor:
Stéphane Auvin, John J. Bissler, Vincent Cottin, Ayataka Fujimoto, Günther F. L. Hofbauer, Anna C. Jansen, Sergiusz Jóźwiak, Larissa Kerecuk, J. Christopher Kingswood, Romina Moavero, Roser Torra, Vicente Villanueva
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-10 (2019)
Abstract Background Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder associated with mutations in TSC1 and TSC2 genes, upregulation of mammalian target of rapamycin signaling, and subsequent tumor formation in various or
Externí odkaz:
https://doaj.org/article/5860f640003143889943eadb4c9b82dc
Autor:
Prashant Kumar, Fahad Zadjali, Ying Yao, Michael Köttgen, Alexis Hofherr, Kenneth W. Gross, Darshan Mehta, John J. Bissler
Publikováno v:
Biology, Vol 11, Iss 5, p 709 (2022)
Patients with autosomal dominant polycystic kidney disease (ADPKD) and tuberous sclerosis complex (TSC) are born with normal or near-normal kidneys that later develop cysts and prematurely lose function. Both renal cystic diseases appear to be mediat
Externí odkaz:
https://doaj.org/article/1dbb8840bd5444d7bdfb49117c6c5786