Zobrazeno 1 - 10
of 204
pro vyhledávání: '"John J, McGuire"'
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 870 (2022)
Perivascular adipose tissue (PVAT) enhances vascular relaxation of mesenteric arteries in SHRSP.Z-Leprfa/IzmDmcr rats (SPZF), a metabolic syndrome model. We investigated and compared the effects of PVAT on the renal artery in SPZF with those on SHR/N
Externí odkaz:
https://doaj.org/article/38863f2c48084d63ac6ff50ffe769db2
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 889 (2022)
Ageing is associated with reduced endothelium-derived nitric oxide (NO) production in the femoral artery of Sprague Dawley (SD) rats. In the current study, we examined endothelium-dependent relaxation (EDR) in the saphenous artery and its caudal bran
Externí odkaz:
https://doaj.org/article/026925a84afa4f1683d6e7b7067b8087
Publikováno v:
Journal of Vascular Research. 59:209-220
Regulation of arterial tone by perivascular adipose tissue (PVAT) differs between sexes. In male SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP.ZF), PVAT exerts a compensatory relaxation effect for the loss of endothelium-mediated vasorelaxation, which occurs du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::791e6a0b4a19542be9be2f6cb5e0d5cf
https://doi.org/10.1159/000524187
https://doi.org/10.1159/000524187
Autor:
Hien C. Nguyen, Shuhan Bu, Sepideh Nikfarjam, Berk Rasheed, David C.R. Michels, Aman Singh, Shweta Singh, Caroline Marszal, John J. McGuire, Qingping Feng, Jefferson C. Frisbee, Mohammad Qadura, Krishna K. Singh
Publikováno v:
Journal of Biological Chemistry. 299:102921
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a06fefaf50efb723791bb54204d3385f
https://doi.org/10.1016/j.jbc.2023.102921
https://doi.org/10.1016/j.jbc.2023.102921
Autor:
John J. McGuire, Jefferson C. Frisbee, Julian H. Lombard, Brayden D. Halvorson, Krishna K. Singh, Paul D. Chantler, Joshua T. Butcher
Publikováno v:
J Vasc Res
The obese Zucker rat (OZR) manifests multiple risk factors for impaired cerebrovascular function, including hypertension and insulin resistance although how they combine to produce integrated vascular function is unclear. As studies have suggested th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70be3f673b67fb0633a48847646db84
https://doi.org/10.1159/000516088
https://doi.org/10.1159/000516088
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 48:211-220
Metabolic syndrome (MetS) increases the risk of kidney disease. In SHRSP.Z-Leprfa /IzmDmcr (SHRSP.ZF) rats with MetS, protease-activated receptor 2 (PAR2)-mediated vasorelaxation is preserved in the aorta at 20 weeks of age (weeks) via enhancement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf8920881246b9aa39dfb647881f444
https://doi.org/10.1111/1440-1681.13431
https://doi.org/10.1111/1440-1681.13431
Autor:
Kim Blenman, Fahad Shabbir Ahmed, Patricia Gaule, John J. McGuire, David L. Rimm, Lajos Pusztai, Katir K Patel
Publikováno v:
Clin Cancer Res
Purpose: In both the IMpassion 130 trial in the metastatic setting and in Keynote 522 in the neoadjuvant setting, patients with triple-negative breast cancer (TNBC) showed benefit from PD-1 axis immunotherapy. Here, we assess PD-L1 expression on both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333ffa2e1b4380d458c294bb606f3a2b
https://doi.org/10.1158/1078-0432.ccr-20-1303
https://doi.org/10.1158/1078-0432.ccr-20-1303
Autor:
Adebowale J. Adeniran, Thuy Tran, Veronique Neumeister, Lucia B. Jilaveanu, John J. McGuire, Sarah A. Weiss, Christopher R. Zito, Harriet M. Kluger, Kazuki Heishima
Publikováno v:
Journal of Neuro-Oncology
Background Although melanoma brain metastases (MBM) tend to respond to systemic therapy concordantly with extracranial metastases, little is known about differences in immune cell and vascular content between the brain and other metastatic sites. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459b787b8394bc5f688be96f60ea99af
https://doi.org/10.1007/s11060-020-03619-0
https://doi.org/10.1007/s11060-020-03619-0
Autor:
Patricia Gaule, John J. McGuire, Kim Blenman, Fahad Shabbir Ahmed, David L. Rimm, Lajos Pusztai
Publikováno v:
Cancer Research. 80:P4-10
Background: In the IMpassion 130 trial, TNBC patients treated with Atezolizumab and nab-Paclitaxel that showed immune cell expression of PD-L1 showed better overall survival. The goal of this analysis was to assess association between quantitative PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e3213414b5c61f5ef4f5a2900d1606
https://doi.org/10.1158/1538-7445.sabcs19-p4-10-14
https://doi.org/10.1158/1538-7445.sabcs19-p4-10-14
Publikováno v:
Journal of vascular research. 59(4)
Regulation of arterial tone by perivascular adipose tissue (PVAT) differs between sexes. In male SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP.ZF), PVAT exerts a compensatory relaxation effect for the loss of endothelium-mediated vasorelaxation, which occurs du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::212c451529656975b24b8e46342c7087
https://pubmed.ncbi.nlm.nih.gov/35490668
https://pubmed.ncbi.nlm.nih.gov/35490668