Zobrazeno 1 - 10
of 266
pro vyhledávání: '"John J, Marchalonis"'
Autor:
Samuel F. Schluter, Kevin Lau, Hao Chen, Roman Covarrubias, Ingvill Jensen, John J. Marchalonis, Sarika Kshirsagar
Publikováno v:
Proceedings of the National Academy of Sciences. 106:8591-8596
Ig and T cell receptor (TCR) genes consist of separate genomic elements, which must undergo rearrangement and joining before a functional protein can be expressed. Considerable plasticity in the genomic arrangement of these elements has occurred duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d969a4b9a8b35832551fd9c269523985
https://doi.org/10.1073/pnas.0811283106
https://doi.org/10.1073/pnas.0811283106
Publikováno v:
International Journal of Immunogenetics. 1:63-67
SUMMARY Immune response (Ir) genes linked to genes encoding histocompatibility antigens affect antibody-formation to synthetic polypeptides, weak native antigens and strong native protein antigens given in limiting doses. It has been proposed that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a29299665b0ae14aa41d3916dcebbff
https://doi.org/10.1111/j.1744-313x.1974.tb00292.x
https://doi.org/10.1111/j.1744-313x.1974.tb00292.x
Publikováno v:
Critical Reviews™ in Immunology. 27:221-232
Although the manifestation of inflammatory autodestructive disease is the result of major immunological dysfunction, recent evidence indicates that the immune system attempts to compensate by the production of immunomodulatory autoantibodies. Healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd82a85c01354ddf1415de593a5c3e64
https://doi.org/10.1615/critrevimmunol.v27.i3.30
https://doi.org/10.1615/critrevimmunol.v27.i3.30
Publikováno v:
Developmental & Comparative Immunology. 30:223-247
All jawed vertebrates contain the genetic elements essential for the function of the adaptive/combinatorial immune response, have diverse sets of natural antibodies resulting from segmental gene recombination, express comparable functional repertoire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f10d8dcac8a739903efa7bce32fdc38
https://doi.org/10.1016/j.dci.2005.06.011
https://doi.org/10.1016/j.dci.2005.06.011
Autor:
Douglas F. Larson, Ramón Tomás Sepúlveda, Samuel F. Schluter, Ronald R. Watson, John J. Marchalonis
Publikováno v:
Annals of the New York Academy of Sciences. 1057:247-259
The operation of the immune system is a complex orchestration of specific self and non-self-recognition capacities mediated by cells of the innate system acting in coordination with T and B lymphocytes in a series of processes modulated by cytokines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ba6ad0bf6799cc5752915f01aeca54
https://doi.org/10.1196/annals.1356.019
https://doi.org/10.1196/annals.1356.019
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 289:H643-H651
The induction of T helper (TH) lymphocytes by distinct TH ligands results in a differentiation to TH1/TH2 subsets based on their unique pattern of cytokine secretion and effector functions. We hypothesized that the relative proportion of TH1/TH2 dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c214da92b5b0366799959c860e915950
https://doi.org/10.1152/ajpheart.00073.2005
https://doi.org/10.1152/ajpheart.00073.2005
Publikováno v:
Cardiovascular Toxicology. 5:021-028
Viral myocarditis is an important cause of heart failure and cardiomyopathy. Immunosenescence, characterized by a dramatic reduction in immune responsiveness, can increase susceptibility to cardiopathology from viral infections. The T-cell receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94365b2daf2803ba8d56851d9b3bf6ef
https://doi.org/10.1385/ct:5:1:021
https://doi.org/10.1385/ct:5:1:021
Publikováno v:
Critical Reviews in Immunology. 24:129-156
Over the last decade, a number of concerns have arisen related to safety issues that have had an adverse effect on the public's trust, particularly among parents whose children are the primary recipient of the vaccine. Historically, the live attenuat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d2e435ea5d8b3ea87ed071b88480ce
https://doi.org/10.1615/critrevimmunol.v24.i2.30
https://doi.org/10.1615/critrevimmunol.v24.i2.30
Publikováno v:
Journal of Cardiovascular Pharmacology. 41:489-497
Infection of people with human immunodeficiency virus (HIV) as well as LP-BM5 infection in mice results in progressive deterioration of the immune system in the majority of untreated hosts. Peptide immunotherapy has been shown to be effective in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1b3b02b6c9cb9797bed6ce520132d8
https://doi.org/10.1097/00005344-200303000-00019
https://doi.org/10.1097/00005344-200303000-00019
Publikováno v:
The FASEB Journal. 17:1-17
The recombination-activating genes (RAG) encode a site-specific recombinase that is centrally responsible for the rearrangement of genomic V(D)J exons necessary to form functional immunoglobulin and T-cell receptor genes. To help elucidate the origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a6aa207d3e2556150c805bec388cea
https://doi.org/10.1096/fj.02-0565fje
https://doi.org/10.1096/fj.02-0565fje