Zobrazeno 1 - 10
of 527
pro vyhledávání: '"John J, Kopchick"'
Autor:
Reetobrata Basu, Prateek Kulkarni, Deborah Swegan, Silvana Duran-Ortiz, Arshad Ahmad, Lydia J. Caggiano, Emily Davis, Christopher Walsh, Edward Brenya, Adeel Koshal, Rich Brody, Uday Sandbhor, Sebastian J. C. M. M. Neggers, John J. Kopchick
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7438 (2024)
Chemotherapy treatment against pancreatic ductal adenocarcinoma (PDAC) is thwarted by tumoral activation of multiple therapy resistance pathways. The growth hormone (GH)–GH receptor (GHR) pair is a covert driver of multimodal therapy resistance in
Externí odkaz:
https://doaj.org/article/1a3f8bb5ee834aec859077d1d8d528f8
Autor:
Patricia Mora‐Criollo, Reetobrata Basu, Yanrong Qian, Kevin Funk, Stephen Bell, Jonathan A. Young, Edward O. List, Jaime A. Costales, Jaime Guevara‐Aguirre, Mario J. Grijalva, John J. Kopchick
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1346-1356 (2023)
Chagas disease (CD) is one of the most devasting parasitic diseases in the Americas, affecting 7–8 million people worldwide. In vitro and in vivo experiments have demonstrated that growth hormone (GH) serum levels decrease as CD progresses. Interes
Externí odkaz:
https://doaj.org/article/63343503754d4c3b9c22ff8271705ef3
Autor:
Francois Moreau, Nicholas S. Kirk, Fa Zhang, Vasily Gelfanov, Edward O. List, Martina Chrudinová, Hari Venugopal, Michael C. Lawrence, Veronica Jimenez, Fatima Bosch, John J. Kopchick, Richard D. DiMarchi, Emrah Altindis, C. Ronald Kahn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The authors previously identified a family of viral insulin-like peptides (VILPs) with high homology to human insulin/IGF−1. Here, they report that one of these VILPs exhibits antagonist properties associated with a unique conformation of the IGF1R
Externí odkaz:
https://doaj.org/article/bfab9e0851234eeaa306dca00cc42caa
Autor:
Reetobrata Basu, Yanrong Qian, Samuel Mathes, Joseph Terry, Nathan Arnett, Trent Riddell, Austin Stevens, Kevin Funk, Stephen Bell, Zac Bokal, Courtney Batten, Cole Smith, Isaac Mendez-Gibson, Silvana Duran-Ortiz, Grace Lach, Patricia Alexandra Mora-Criollo, Prateek Kulkarni, Emily Davis, Elizabeth Teaford, Darlene E. Berryman, Edward O. List, Sebastian Neggers, John J. Kopchick
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Knockdown of GH receptor (GHR) in melanoma cells in vitro downregulates ATP-binding cassette-containing (ABC) transporters and sensitizes them to anti-cancer drug treatments. Here we aimed to determine whether a GHR antagonist (GHRA) could control ca
Externí odkaz:
https://doaj.org/article/d2ffbe802ebd4cbd9ac35e71d0449a98
Autor:
Edward O. List, Darlene E. Berryman, Elizabeth A. Jensen, Prateek Kulkarni, Savannah McKenna, John J. Kopchick
Publikováno v:
Archives of Endocrinology and Metabolism, Vol 63, Iss 6, Pp 557-567 (2020)
ABSTRACT In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created
Externí odkaz:
https://doaj.org/article/aac410e6603b4e83a5765e8bbcdbc3f7
Autor:
Jonathan A. Young, Silvana Duran-Ortiz, Stephen Bell, Kevin Funk, Yuan Tian, Qing Liu, Andrew D. Patterson, Edward O. List, Darlene E. Berryman, John J. Kopchick
Publikováno v:
Metabolites, Vol 13, Iss 2, p 191 (2023)
Growth hormone (GH) has established effects on protein metabolism, such as increasing protein synthesis and decreasing amino acid degradation, but its effects on circulating amino acid levels are less studied. To investigate this relationship, metabo
Externí odkaz:
https://doaj.org/article/d6c1cf127a394246a0b5fc02261f2112
Autor:
Astrid Johannesson Hjelholt, Kevin Y. Lee, Mai Christiansen Arlien-Søborg, Steen Bønløkke Pedersen, John J. Kopchick, Vishwajeet Puri, Niels Jessen, Jens Otto L. Jørgensen
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 65-75 (2019)
Objective: Growth hormone (GH) stimulates lipolysis, but the underlying mechanisms remain incompletely understood. We examined the effect of GH on the expression of lipolytic regulators in adipose tissue (AT). Methods: In a randomized, placebo-contro
Externí odkaz:
https://doaj.org/article/df977ca1ec0d4245be3b77f6148036fd
Autor:
William R. Swindell, Colin P. S. Kruse, Edward O. List, Darlene E. Berryman, John J. Kopchick
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-33 (2019)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment options. Progress towards new therapies requires validated disease biomarkers, but there is no consensus on which fluid-based measures are most infor
Externí odkaz:
https://doaj.org/article/8ef25d2ce5c64d18b8bacb2a063e9dd9
Autor:
Isadora C. Furigo, Pryscila D. S. Teixeira, Gabriel O. de Souza, Gisele C. L. Couto, Guadalupe García Romero, Mario Perelló, Renata Frazão, Lucila L. Elias, Martin Metzger, Edward O. List, John J. Kopchick, J. Donato
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Reduction in food intake elicits neuroendocrine adaptations to counterregulate the negative energy balance, e.g. via reduction in leptin levels. Here, the authors identify an additional starvation signal, growth hormone (GH). Blocking GH receptor att
Externí odkaz:
https://doaj.org/article/d4067e42ca514c9c9b243f9101c626a6
Autor:
Christopher J. Unterberger, Sean J. McIlwain, Philippos K. Tsourkas, Vilena I. Maklakova, Jordyn L. Prince, Abigail Onesti, Rong Hu, John J. Kopchick, Steven M. Swanson, Paul C. Marker
Publikováno v:
The Prostate. 83:416-429
Humans with inactivating mutations in growth hormone receptor (GHR) have lower rates of cancer, including prostate cancer. Similarly, mice with inactivating Ghr mutations are protected from prostatic intraepithelial neoplasia in the C3(1)/TAg prostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15725ae900bb4415e6e2a0546a4e037
https://doi.org/10.1002/pros.24474
https://doi.org/10.1002/pros.24474