Výsledky vyhledávání - "John Isaac Murray"

Akademický článek

Computational modeling and analysis of the morphogenetic domain signaling networks regulating C. elegans embryogenesis

Autor: Ben Niu, Thao Nguyen Bach, Xingyu Chen, Khyati Raghunath Chandratre, John Isaac Murray, Zhongying Zhao, Michael Zhang

Publikováno v: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3653-3666 (2022)

Caenorhabditis elegans, often referred to as the ‘roundworm’, provides a powerful model for studying cell autonomous and cell–cell interactions through the direct observation of embryonic development in vivo. By leveraging the precisely mapped

Externí odkaz: https://doaj.org/article/157553a99d7047b5badd4bdf4a9f0446

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Akademický článek

The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo.

Autor: John Isaac Murray, Elicia Preston, Jeremy P Crawford, Jonathan D Rumley, Prativa Amom, Breana D Anderson, Priya Sivaramakrishnan, Shaili D Patel, Barrington Alexander Bennett, Teddy D Lavon, Erin Hsiao, Felicia Peng, Amanda L Zacharias

Publikováno v: PLoS Genetics, Vol 18, Iss 5, p e1010187 (2022)

Hox transcription factors play a conserved role in specifying positional identity during animal development, with posterior Hox genes typically repressing the expression of more anterior Hox genes. Here, we dissect the regulation of the posterior Hox

Externí odkaz: https://doaj.org/article/3d5f2234c86848358185a8a66c649d1f

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Akademický článek

H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

Autor: Andrey Poleshko, Cheryl L Smith, Son C Nguyen, Priya Sivaramakrishnan, Karen G Wong, John Isaac Murray, Melike Lakadamyali, Eric F Joyce, Rajan Jain, Jonathan A Epstein

Publikováno v: eLife, Vol 8 (2019)

Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of

Externí odkaz: https://doaj.org/article/c643add60c814c8f8717b69f653b18d6

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Akademický článek

Silencing the alternative

Autor: Priya Sivaramakrishnan, John Isaac Murray

Publikováno v: eLife, Vol 8 (2019)

The transcription factor ztf-11 promotes neuronal differentiation by repressing other cell fates in the nematode worm C. elegans.

Externí odkaz: https://doaj.org/article/316e7f82e9fa40e1901eaf94c0914578

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Akademický článek

Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in C. elegans.

Autor: Amanda L Zacharias, Travis Walton, Elicia Preston, John Isaac Murray

Publikováno v: PLoS Genetics, Vol 11, Iss 10, p e1005585 (2015)

The Wnt signaling pathway plays a conserved role during animal development in transcriptional regulation of distinct targets in different developmental contexts but it remains unclear whether quantitative differences in the nuclear localization of ef

Externí odkaz: https://doaj.org/article/e8ceea5f6df742208df49f6aa8c818d5

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Akademický článek

The Bicoid class homeodomain factors ceh-36/OTX and unc-30/PITX cooperate in C. elegans embryonic progenitor cells to regulate robust development.

Autor: Travis Walton, Elicia Preston, Gautham Nair, Amanda L Zacharias, Arjun Raj, John Isaac Murray

Publikováno v: PLoS Genetics, Vol 11, Iss 3, p e1005003 (2015)

While many transcriptional regulators of pluripotent and terminally differentiated states have been identified, regulation of intermediate progenitor states is less well understood. Previous high throughput cellular resolution expression studies iden

Externí odkaz: https://doaj.org/article/8f4f9493e9774691b8d464c60973ae0c

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pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo

Autor: Jonathan D. Rumley, Elicia A. Preston, Dylan Cook, Felicia L. Peng, Amanda L. Zacharias, Lucy Wu, Ilona Jileaeva, John Isaac Murray

Publikováno v: Developmental Biology. 489:34-46

Patterning of the anterior-posterior axis is fundamental to animal development. The Wnt pathway plays a major role in this process by activating the expression of posterior genes in animals from worms to humans. This observation raises the question o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1c6bf90e0d1dcfd250b54806a8139e
https://doi.org/10.1016/j.ydbio.2022.05.019

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