Zobrazeno 1 - 10
of 903
pro vyhledávání: '"John Inge"'
Autor:
Thale K. Olsen, Jörg Otte, Shenglin Mei, Bethel Tesfai Embaie, Polina Kameneva, Huaitao Cheng, Teng Gao, Vasilios Zachariadis, Ioanna Tsea, Åsa Björklund, Emil Kryukov, Ziyi Hou, Anna Johansson, Erik Sundström, Tommy Martinsson, Susanne Fransson, Jakob Stenman, Shahrzad Shirazi Fard, John Inge Johnsen, Per Kogner, Igor Adameyko, Martin Enge, Peter V. Kharchenko, Ninib Baryawno
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Neuroblastoma (NB) is a heterogeneous embryonal malignancy and the deadliest tumor of infancy. It is a complex disease that can result in diverse clinical outcomes. In some children, tumors regress spontaneously. Others respond we
Externí odkaz:
https://doaj.org/article/1d5da37f62bb4e9c8494a94bf33d81b4
Publikováno v:
Journal of Mathematics in Industry, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract In the present paper the high-frequency induction welding process is studied numerically. The mathematical model comprises a harmonic vector potential formulation of the Maxwell equations and a quasi-static, convection dominated heat equatio
Externí odkaz:
https://doaj.org/article/55d5906c0e23456e9b3d20ea17fbcc1a
Autor:
Shenglin Mei, Adele M. Alchahin, Ioanna Tsea, Youmna Kfoury, Taghreed Hirz, Nathan Elias Jeffries, Ting Zhao, Yanxin Xu, Hanyu Zhang, Hirak Sarkar, Shulin Wu, Alexander O. Subtelny, John Inge Johnsen, Yida Zhang, Keyan Salari, Chin-Lee Wu, Mark A. Randolph, David T. Scadden, Douglas M. Dahl, John Shin, Peter V. Kharchenko, Philip J. Saylor, David B. Sykes, Ninib Baryawno
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Background Despite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of patients with advanced clear cell renal cell carcinoma (ccRCC) present with bone metastasis a
Externí odkaz:
https://doaj.org/article/f630748728fb49e9b520cfa367f96514
Autor:
Songbai Zhang, Ayako Miyakawa, Malin Wickström, Cecilia Dyberg, Lauri Louhivuori, Manuel Varas-Godoy, Kati Kemppainen, Shigeaki Kanatani, Dagmara Kaczynska, Ivar Dehnisch Ellström, Lotta Elfman, Pauliina Kronqvist, Heli Repo, Katsuhiko Mikoshiba, Cecilia Sahlgren, John Inge Johnsen, Per Uhlén
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Notch signalling is reported to be hyperactivated in oestrogen receptor-negative (ER-) breast cancer. Here the authors show that G protein-coupled receptor kinase-interacting protein 1 (GIT1) negatively regulates Notch signalling and tumour growth in
Externí odkaz:
https://doaj.org/article/bcf68ef5145e4a00816fadb87092743a
Autor:
Vanja Börjesson, Angela Martinez-Monleon, Susanne Fransson, Per Kogner, John Inge Johnsen, Jelena Milosevic, Marcela Dávila López
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Transgenic animal models are crucial for the study of gene function and disease, and are widely utilized in basic biological research, agriculture and pharma industries. Since the current methods for generating transgenic animals
Externí odkaz:
https://doaj.org/article/47af39ab33474b46838f14ea3cd45aee
Autor:
Tatiana A. Giovannucci, Florian A. Salomons, Martin Haraldsson, Lotta H. M. Elfman, Malin Wickström, Patrick Young, Thomas Lundbäck, Jürgen Eirich, Mikael Altun, Rozbeh Jafari, Anna-Lena Gustavsson, John Inge Johnsen, Nico P. Dantuma
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-19 (2021)
Abstract Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery
Externí odkaz:
https://doaj.org/article/40038c990d214b6aae378be5f01e4f1b
Autor:
Thale Kristin Olsen, Cecilia Dyberg, Bethel Tesfai Embaie, Adele Alchahin, Jelena Milosevic, Jane Ding, Jörg Otte, Conny Tümmler, Ida Hed Myrberg, Ellen M. Westerhout, Jan Koster, Rogier Versteeg, Han-Fei Ding, Per Kogner, John Inge Johnsen, David B. Sykes, Ninib Baryawno
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Despite intensive therapy, children with high-risk neuroblastoma are at risk of treatment failure. We applied a multiomic system approach to evaluate metabolic vulnerabilities in human neuroblastoma. We combined metabolomics, CRISPR screening, and tr
Externí odkaz:
https://doaj.org/article/2b75513611ff4f3b9d9eca1d88064b72
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Dysregulated expression of the transcription factor MYCN is frequently detected in nervous system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a single oncogenic driver inducing neoplastic transformation in neural crest
Externí odkaz:
https://doaj.org/article/aaad09d4a800423f841c6eaad15e9530
Autor:
Chuanyou Xia, Thale Kristin Olsen, A. Ali Zirakzadeh, Radwa Almamoun, Louise K. Sjöholm, Jenny Dahlström, Jan Sjöberg, Hans-Erik Claesson, John Inge Johnsen, Ola Winqvist, Dawei Xu, Tomas J. Ekström, Magnus Björkholm, Klas Strååt
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing th
Externí odkaz:
https://doaj.org/article/94f4986070ae4c41a106c7e70907ce02
Autor:
Kashif Rasheed, Ugo Moens, Benedetta Policastro, John Inge Johnsen, Virve Koljonen, Harri Sihto, Weng-Onn Lui, Baldur Sveinbjørnsson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3702 (2022)
Merkel cell polyomavirus (MCPyV) is a causal factor in Merkel cell carcinoma (MCC). The oncogenic potential is mediated through its viral oncoproteins large T-antigen (LT) and small T-antigen (sT). Cytokines produced by tumor cells play an important
Externí odkaz:
https://doaj.org/article/dd2f043603034a0b89f26e3437d27af4