Zobrazeno 1 - 8 of 8 pro vyhledávání: '"John I. McKenna"'
1
4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter
Autor: David A. Quincy, Nicholas R. Natale, Victoria Hulubei, John I. McKenna, Tina Houle, Scott A. Steiger, Mark E. Rogers, Scott B. Meikrantz
Publikováno v: Bioorganic & Medicinal Chemistry. 20:6613-6620
The 4-isoxazolyl-dihydropyridines (IDHPs) exhibit inhibition of the multidrug-resistance transporter (MDR-1), and exhibit an SAR distinct from their activity at voltage gated calcium channels (VGCC). Among the four most active IDHPs, three were branc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7259b0e172b467cffb5e17a6a920b13
https://doi.org/10.1016/j.bmc.2012.09.022
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2
The mass spectral fragmentation of isoxazolyldihydropyridines
Autor: David A. Quincy, John I. McKenna, Nicholas R. Natale, Gary Knerr
Publikováno v: Journal of Heterocyclic Chemistry. 24:1429-1433
The mass spectral fragmentation of 4-isoxazolyl-1,4-dihydropyridines has been examined with the aid of linked metastable scanning. Three prominent pathways involve (i) O-N bond cleavage of the isoxazole followed by the loss of R2CN, (ii) loss of carb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc7105f2b6cc969a55911196a5ad7d1c
https://doi.org/10.1002/jhet.5570240541
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4
ChemInform Abstract: The Mass Spectral Fragmentation of Isoxazolyldihydropyridines
Autor: Gary Knerr, John I. McKenna, David A. Quincy, Nicholas R. Natale
Publikováno v: ChemInform. 19
The mass spectral fragmentation of 4-isoxazolyl-1,4-dihydropyridines has been examined with the aid of linked metastable scanning. Three prominent pathways involve (i) O-N bond cleavage of the isoxazole followed by the loss of R2CN, (ii) loss of carb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a200f154b37cec457771056563196e1c
https://doi.org/10.1002/chin.198815042
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6
Cardioactivity and solid-state structure of two 4-isoxazolyldihydropyridines related to the 4-aryldihydropyridine calcium-channel blockers
Autor: Stephen F. Flaim, Roger D. Willett, Ludwig Schlicksupp, John I. McKenna, Bruce E. Maryanoff, Nicholas R. Natale
Publikováno v: Journal of medicinal chemistry. 31(2)
Diethyl 2,6-dimethyl-4-(5-ethyl-3-phenylisoxazol-4-yl)-1,4-dihydroyprid ine-3,5- dicarboxylate (5) and diethyl 2,6-dimethyl-4-(5-isopropyl-3-phenylisoxazol-4-yl)-1,4-dihydropyri dine-3,5- dicarboxylate (6) were synthesized, and their molecular struct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6d9f7ad7903b3aa66810ff2530ea67
https://pubmed.ncbi.nlm.nih.gov/3339618
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7
Selective oxidation in the presence of a heterocycle
Autor: K. Dean Bowles, John I. McKenna, Nicholas R. Natale, David A. Quincy
Publikováno v: Journal of Chemical Education. 63:358
The process of weighing the advantages and disadvantages of various oxidation methods are presented in this paper.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6466ee8b19ba95e9aeaa69105c1d631
https://doi.org/10.1021/ed063p358
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8
Heterocycles and reactive intermediates in the undergraduate organic lab
Autor: Nicholas R. Natale, John I. McKenna, K. Dean Bowles, Brenda M. Mallet, David A. Quincy
Publikováno v: Journal of Chemical Education. 62:1118
The nitrile oxide cycloaddition with enamines is useful in illustrating the concepts of reactive intermediates in synthesis and frontier molecular orbital theory.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3573e8d3e4afe6da7b39e1857f5da6a
https://doi.org/10.1021/ed062p1118
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