Zobrazeno 1 - 10
of 98
pro vyhledávání: '"John I, Trujillo"'
Autor:
David Jonathan Wasilko, Brian S. Gerstenberger, Kathleen A. Farley, Wei Li, Jennifer Alley, Mark E. Schnute, Ray J. Unwalla, Jorge Victorino, Kimberly K. Crouse, Ru Ding, Parag V. Sahasrabudhe, Fabien Vincent, Richard K. Frisbie, Alpay Dermenci, Andrew Flick, Chulho Choi, Gary Chinigo, James J. Mousseau, John I. Trujillo, Philippe Nuhant, Prolay Mondal, Vincent Lombardo, Daniel Lamb, Barbara J. Hogan, Gurdeep Singh Minhas, Elena Segala, Christine Oswald, Ian W. Windsor, Seungil Han, Mathieu Rappas, Robert M. Cooke, Matthew F. Calabrese, Gabriel Berstein, Atli Thorarensen, Huixian Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The CC chemokine receptor 6 (CCR6) is a potential target for chronic inflammatory diseases. Previously, we reported an active CCR6 structure in complex with its cognate chemokine CCL20, revealing the molecular basis of CCR6 activation. Here,
Externí odkaz:
https://doaj.org/article/91af6bd491994266b492f68b0994ea6e
Autor:
Mark E. Schnute, John I. Trujillo, Katherine L. Lee, Ray Unwalla, Felix F. Vajdos, Björn Kauppi, Philippe Nuhant, Andrew C. Flick, Kimberly K. Crouse, Yajuan Zhao, Amanda Samuel, Vincent Lombardo, Alexandria P. Taylor, Amy L. Brault, John D. Knafels, Michael L. Vazquez, Gabriel Berstein
Publikováno v:
ACS Medicinal Chemistry Letters. 14:191-198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7cb9137d3953ca89b3dd2890f9f1be
https://doi.org/10.1021/acsmedchemlett.2c00500
https://doi.org/10.1021/acsmedchemlett.2c00500
Autor:
Louise Bernier, Vincent Michael Lombardo, Neal W. Sach, Yong Tao, William Farrell, Andrew C. Flick, John I. Trujillo, Philippe Nuhant, Ming Z. Chen
Publikováno v:
Organic Process Research & Development. 25:2315-2322
Despite chiral piperidines being a commonly found motif in approved drugs and drug candidates, the synthesis of these compounds occasionally suffers from challenges of scalability and stereochemica...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc9c5895446cb8aaed07cb07efcb1b44
https://doi.org/10.1021/acs.oprd.1c00212
https://doi.org/10.1021/acs.oprd.1c00212
Autor:
Kevin P. Girard, Ruchi Mehta, Chen Xiaofeng, Wiglesworth Kristin, Feng Shi, John I. Trujillo, Tangqing Li, Jason Mustakis, Chengfu Xie, Teresa M. Makowski, Qing Zhang, J. Christopher McWilliams, Yong Tao, Neal W. Sach
Publikováno v:
Organic Process Research & Development. 23:1872-1880
A scalable process for PF-06651600 (1) has been developed through successful enabling of the first generation syntheis. The synthesis highlights include the following: (1) replacement of costly PtO...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b285c4cf5c5986c5ca54ad8c40583d5
https://doi.org/10.1021/acs.oprd.9b00198
https://doi.org/10.1021/acs.oprd.9b00198
Autor:
Iain Kilty, Uthpala Seneviratne, M Nusrat Sharif, Gary R. Point, Jean-Baptiste Telliez, Tsung H. Lin, Douglas S. Johnson, Michael I. Jesson, John I. Trujillo, Chuong Nguyen, Hua Xu, Liang Xue, Robert A. Everley, Atli Thorarensen
Publikováno v:
ACS Chemical Biology. 14:1235-1242
PF-06651600 was developed as an irreversible inhibitor of JAK3 with selectivity over the other three JAK isoforms. A high level of selectivity toward JAK3 is achieved by the covalent interaction of PF-06651600 with a unique cysteine residue (Cys-909)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ed51fa955664495a184af61925bde2
https://doi.org/10.1021/acschembio.9b00188
https://doi.org/10.1021/acschembio.9b00188
Publikováno v:
The Journal of organic chemistry. 85(23)
In a recent methodological study investigating the synthesis of N-alkoxyazomethine ylides, an unexpected aminal byproduct was generated during our attempt to isolate O-benzyl-N-((trimethylsilyl)methyl)hydroxylamine. After a strategic investigation, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774cc0e4759fdebe8b5d812db9407635
https://pubmed.ncbi.nlm.nih.gov/33226802
https://pubmed.ncbi.nlm.nih.gov/33226802
Autor:
Brett D. Hollingshead, Fabien Vincent, Tsung H. Lin, John I. Trujillo, Betsy Pierce, Andrew Fensome, Brian S. Gerstenberger, Martin E. Dowty, Matthew Frank Brown, Xin Yang, David C. Limburg, Martin Hegen, John D. Knafels, Felix Vajdos, Andrew C. Flick, Mary Ellen Banker, Raman Sharma, Li Xing, Jason Jussif, Catherine M. Ambler, Ivan Viktorovich Efremov, James D. Clark, Liying Zhang, Peter T. Symanowicz, Eddine Saiah, Jill Chrencik, Jean-Baptiste Telliez, Xiaojing Yang, Eric P. Arnold, Ariamala Gopalsamy, Zhao-Kui Wan, Matthew Merrill Hayward, David W. Lin
Publikováno v:
Journal of Medicinal Chemistry. 61:8597-8612
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d4f153dbb8b5bb68fb24a9742305143
https://doi.org/10.1021/acs.jmedchem.8b00917
https://doi.org/10.1021/acs.jmedchem.8b00917
Autor:
John I. Trujillo, Paul Richardson
Publikováno v:
Synfacts. 17:1330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e66f3a9949775d9df53dfdf914b4b39
https://doi.org/10.1055/s-0041-1737104
https://doi.org/10.1055/s-0041-1737104
Autor:
Paul G. Richardson, John I. Trujillo
Publikováno v:
Synfacts. 17:1327
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::443c8c5387bd58b5606ef74b47c0f8c5
https://doi.org/10.1055/s-0041-1737105
https://doi.org/10.1055/s-0041-1737105
Autor:
Paul G. Richardson, John I. Trujillo
Publikováno v:
Synfacts. 17:1197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b7d4730a26bc5d71d9e596319fde7a5
https://doi.org/10.1055/s-0040-1720699
https://doi.org/10.1055/s-0040-1720699