Zobrazeno 1 - 10
of 1 273
pro vyhledávání: '"John Hwa"'
Autor:
Seung Hee Lee, Suyeon Cho, Jong Youl Lee, Ji Yeon Kim, Suji Kim, Myoungho Jeong, Jung Yeon Hong, Geun-Young Kim, Seung Woo Lee, Eunmi Kim, Jihwa Kim, Jee Woong Kim, John Hwa, Won-Ho Kim
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Diabetes mellitus (DM) is a progressive, chronic metabolic disorder characterized by high oxidative stress, which can lead to cardiac damage. Methionine sulfoxylation (MetO) of proteins by excessive reactive oxygen species (ROS) can impair t
Externí odkaz:
https://doaj.org/article/257fa5861b404ec7b6c82cc2042998ed
Publikováno v:
Journal of Advanced Research, Vol 61, Iss , Pp 83-100 (2024)
Introduction: The limitations of conventional cancer therapies necessitate target-oriented, highly invasive, and safe treatment approaches. Hence, the intrinsic anti-tumor activity of Salmonella can offer better options to combat cancers. Objectives:
Externí odkaz:
https://doaj.org/article/e40267b01dcc4fe6ad16d60485e230e9
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107256- (2024)
Inflammation is a crucial factor in cardiac remodeling after acute myocardial infarction (MI). Neutrophils, as the first wave of leukocytes to infiltrate the injured myocardium, exacerbate inflammation and cardiac injury. However, therapies that depl
Externí odkaz:
https://doaj.org/article/14c03b14486a4b0184464a005282efbf
Publikováno v:
Poultry Science, Vol 103, Iss 7, Pp 103844- (2024)
ABSTRACT: An effective vaccine strategy is indispensable against infectious bronchitis virus (IBV) and fowl typhoid (FT), both of which threaten the poultry industry. This study demonstrates a vector system, pJHL270, designed to express antigens in p
Externí odkaz:
https://doaj.org/article/90f22e6395134de9a6fda0d584333a2d
Publikováno v:
Engineering, Vol 32, Iss , Pp 41-56 (2024)
A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines. In this study, a strategy called computationally optimized broadly reactive antigen (COBRA) was used to
Externí odkaz:
https://doaj.org/article/dbc7803b0e3a4568b418c56fc5487bb2
Autor:
Perumalraja Kirthika, Amal Senevirathne, Sungwoo Park, Ram Prasad Aganja, In-Shik Kim, Hyun-Jin Tae, John Hwa Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9056 (2024)
In the current study, two Salmonella Typhimurium strains, JOL 912 and JOL 1800, were engineered from the wild-type JOL 401 strain through in-frame deletions of the lon and cpxR genes, with JOL 1800 also lacking rfaL. These deletions significantly att
Externí odkaz:
https://doaj.org/article/475854fe77bc4ec897bd9dcb36322c1c
Publikováno v:
Poultry Science, Vol 103, Iss 2, Pp 103354- (2024)
ABSTRACT: In this study, we incorporated deletion of the O-antigen ligase gene to an attenuated Salmonella Enteritidis (SE) strain, JOL919 (SE PS; Δlon ΔcpxR), using the Lambda-Red recombination method and evaluated the safety and immunological asp
Externí odkaz:
https://doaj.org/article/047c1cb6cb404fff878d08ebad8cf481
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6394 (2024)
In our prior investigations, we elucidated the role of the tryptophan-to-tyrosine substitution at the 61st position in the nonstructural protein NSsW61Y in diminishing the interaction between nonstructural proteins (NSs) and nucleoprotein (NP), imped
Externí odkaz:
https://doaj.org/article/9abc69f02420449db414b3762f4f25dd
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102053- (2023)
Emerging chemo- and radiotherapy resistance exacerbated the cancer risk and necessitated novel treatment strategies. Although RNA therapeutics against pro-oncogenic genes are highly effective, tumor-specific delivery remains a barrier to the implemen
Externí odkaz:
https://doaj.org/article/9a85a65ab5d34eae8506d158b5a48b80
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2760 (2024)
The lipopolysaccharide (LPS) that resides on the outermost surface and protects Gram-negative bacteria from host defenses is one of the key components leading to Salmonella infection, particularly the endotoxic lipid A domain of LPS. Lipid A modifica
Externí odkaz:
https://doaj.org/article/01817892abb84835a6e4a9a34b03a776