Výsledky vyhledávání - "John Hilkens"

Akademický článek

IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation

Autor: Gerjon J. Ikink, Mandy Boer, Elvira R. M. Bakker, John Hilkens

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

IRS proteins are scaffolds that can activate survival signalling pathways. In this study, the authors identified IRS4 as a potential oncogene in breast cancer that leads to the constitutive activation of PI3K/AKT signalling and thus confers resistanc

Externí odkaz: https://doaj.org/article/7589cf0b1b644bf996fe00987062fff0

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Akademický článek

Insulin receptor substrate 4 (IRS4) is a constitutive active oncogenic driver collaborating with HER2 and causing therapeutic resistance

Autor: Gerjon J. Ikink, John Hilkens

Publikováno v: Molecular & Cellular Oncology, Vol 4, Iss 2 (2017)

Insulin receptor substrate 4 (IRS4) belongs to a family of cytoplasmic docking proteins mediating signals from cell surface receptors to downstream effectors. While IRS1 and IRS2 mediate signals from an active receptor, we found that IRS4 hyperactiva

Externí odkaz: https://doaj.org/article/946d5c96a46a4bebb50b88edcf076a2d

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Akademický článek

MUC1-ARF-A Novel MUC1 Protein That Resides in the Nucleus and Is Expressed by Alternate Reading Frame Translation of MUC1 mRNA.

Autor: Michael Chalick, Oded Jacobi, Edward Pichinuk, Christian Garbar, Armand Bensussan, Alan Meeker, Ravit Ziv, Tania Zehavi, Nechama I Smorodinsky, John Hilkens, Franz-Georg Hanisch, Daniel B Rubinstein, Daniel H Wreschner

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165031 (2016)

Translation of mRNA in alternate reading frames (ARF) is a naturally occurring process heretofore underappreciated as a generator of protein diversity. The MUC1 gene encodes MUC1-TM, a signal-transducing trans-membrane protein highly expressed in hum

Externí odkaz: https://doaj.org/article/e148be4c47a04d5dbe84a96ede250065

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Akademický článek

Chromatin landscapes of retroviral and transposon integration profiles.

Autor: Johann de Jong, Waseem Akhtar, Jitendra Badhai, Alistair G Rust, Roland Rad, John Hilkens, Anton Berns, Maarten van Lohuizen, Lodewyk F A Wessels, Jeroen de Ridder

Publikováno v: PLoS Genetics, Vol 10, Iss 4, p e1004250 (2014)

The ability of retroviruses and transposons to insert their genetic material into host DNA makes them widely used tools in molecular biology, cancer research and gene therapy. However, these systems have biases that may strongly affect research outco

Externí odkaz: https://doaj.org/article/1fdb8ab45ba54001862e8a69f4a6e2fa

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