Zobrazeno 1 - 10
of 69
pro vyhledávání: '"John Hey"'
Autor:
John Hey, Susan Abushakra, Kaj Blennow, Philip Scheltens, Jakub Hort, Katerina Sheardova, Niels Prins, Sterre Rutgers, Paul Dautzenberg, Ladislav Pazdera, Patrick Kesslak, Rosalind Mandelbaum, Aidan Power, Martin Tolar
Publikováno v:
Tuesday, April 25.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e96be3ec8d86f43d71ef009bf3285f50
https://doi.org/10.1212/wnl.0000000000203129
https://doi.org/10.1212/wnl.0000000000203129
Autor:
Susan Abushakra, Rosalind Mandelbaum, Jerome Barakos, Philip Scheltens, Anton P. Porsteinsson, David Watson, Emer MacSweeney, Marwan Sabbagh, Earvin Liang, Patrick Kesslak, Joyce Suhy, Aidan Power, John Hey, Martin Tolar
Publikováno v:
Monday, April 24.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97dbb76734a6930717b1a67c64742f8d
https://doi.org/10.1212/wnl.0000000000203550
https://doi.org/10.1212/wnl.0000000000203550
Autor:
Susan Abushakra, John Hey, Kaj Blennow, Philip Scheltens, Eric M. Reiman, Jakub Hort, Katerina Sheardova, Sterre M. Rutgers, Niels D. Prins, Paul Dautzenberg, Ladislav Pazdera, Aidan Power, Martin Tolar
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::442741ac79c4a688dc78ce0e96821a0c
https://doi.org/10.1002/alz.069141
https://doi.org/10.1002/alz.069141
Autor:
Sheeba J. Sujit, Muhammad Aminu, Tatiana V. Karpinets, Pingjun Chen, Maliazurina B. Saad, Morteza Salehjahromi, John D. Boom, Mohamed Qayati, James M. George, Haley Allen, Mara B. Antonoff, Lingzhi Hong, Xin Hu, Simon Heeke, Hai T. Tran, Xiuning Le, Yasir Y. Elamin, Mehmet Altan, Natalie I. Vokes, Ajay Sheshadri, Julie Lin, Jianhua Zhang, Yang Lu, Carmen Behrens, Myrna C. B. Godoy, Carol C. Wu, Joe Y. Chang, Caroline Chung, David A. Jaffray, Ignacio I. Wistuba, J. Jack Lee, Ara A. Vaporciyan, Don L. Gibbons, John Heymach, Jianjun Zhang, Tina Cascone, Jia Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract While we recognize the prognostic importance of clinicopathological measures and circulating tumor DNA (ctDNA), the independent contribution of quantitative image markers to prognosis in non-small cell lung cancer (NSCLC) remains underexplor
Externí odkaz:
https://doaj.org/article/8ee2d864530b4ff5bcd6763fb81cd4af
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6355, p 6355 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
A large body of clinical and nonclinical evidence supports the role of neurotoxic soluble beta amyloid (amyloid, Aβ) oligomers as upstream pathogenic drivers of Alzheimer’s disease (AD). Recent late-stage trials in AD that have evaluated agents ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e627430340ec86b838afa12eafd462fc
https://pubmed.ncbi.nlm.nih.gov/34198582
https://pubmed.ncbi.nlm.nih.gov/34198582
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
The body of evidence suggesting a causative, initiating role of beta amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (AD) is substantial. Yet, only a few anti-amyloid agents have shown meaningful efficacy in clinical trials. We evaluated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dced2a06dc79e8063f7a1f33804b6e4
http://europepmc.org/articles/PMC7424995
http://europepmc.org/articles/PMC7424995
Autor:
John Hey, Martin Tolar, Aidan Power, Susan Abushakra, Martin Vyhnalek, Petr Kocis, Jeremy Yu, Jakub Hort
Publikováno v:
CNS Drugs
Background ALZ-801 is an oral, small-molecule inhibitor of beta amyloid (Aβ) oligomer formation in clinical development for Alzheimer’s disease (AD). ALZ-801 is a prodrug of tramiprosate with improved pharmacokinetic properties and gastrointestina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb13b834f0026f5e5b000f5f46c3202d
https://doi.org/10.1007/s40263-018-0554-0
https://doi.org/10.1007/s40263-018-0554-0
Autor:
Sara Nofal, Jiangong Niu, Paul Resong, Jeff Jin, Kelly W. Merriman, Xiuning Le, Hormuzd Katki, John Heymach, Mara B. Antonoff, Edwin Ostrin, Jia Wu, Jianjun Zhang, Iakovos Toumazis
Publikováno v:
Cancer Medicine, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Background Personal history of cancer is an independent risk factor for lung cancer but is omitted from existing lung cancer screening eligibility criteria. In this study, we assess the lung cancer risk among cancer survivors and discuss pot
Externí odkaz:
https://doaj.org/article/f73f39eab8e54b36bd81a75911db0cf9
Autor:
William Sinko, Petr Kocis, Howard Fillit, Soumya S. Ray, John Hey, Kaj Blennow, Jeremy Yu, Martin Tolar
Publikováno v:
CNS Drugs
Background Amyloid beta (Aβ) oligomers play a critical role in the pathogenesis of Alzheimer’s disease (AD) and represent a promising target for drug development. Tramiprosate is a small-molecule Aβ anti-aggregation agent that was evaluated in ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b500eff279eb969bdf49fbfc5cda4cb
https://doi.org/10.1007/s40263-017-0434-z
https://doi.org/10.1007/s40263-017-0434-z
Autor:
John Hey, Martin Vyhnalek, Jeremy Yu, Martin Tolar, Petr Kocis, Aidan Power, Susan Abushakra, Jakub Hort
Publikováno v:
Alzheimer's & Dementia. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc297d251771a9f06e06996787040f22
https://doi.org/10.1016/j.jalz.2019.06.068
https://doi.org/10.1016/j.jalz.2019.06.068