Zobrazeno 1 - 10 of 63 pro vyhledávání: '"John Harlan"'
1
Akademický článek
The use of cyclic peptide antigens to generate LRP8 specific antibodies
Autor: Maria A. Argiriadi, Kangwen Deng, David Egan, Lei Gao, Farid Gizatullin, John Harlan, Denise Karaoglu Hanzatian, Wei Qiu, Ruth Villanueva, Andrew Goodearl
Publikováno v: Frontiers in Drug Discovery, Vol 2 (2023)
LRP8 is a member of the LDLR-like protein family. It is a transport receptor, which can be used in the design of antibodies specific for investigating increasing exposure to therapeutics with respect to the blood brain barrier (BBB). In this study, a
Externí odkaz: https://doaj.org/article/7cf38b5884c6403890eae361615c7e1f
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2
Akademický článek
CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches
Autor: Maria A. Argiriadi, Lorenzo Benatuil, Ievgeniia Dubrovska, David A. Egan, Lei Gao, Amy Greischar, Jennifer Hardman, John Harlan, Ramesh B. Iyer, Russell A. Judge, Marc Lake, Denise C. Perron, Ramkrishna Sadhukhan, Bernhard Sielaff, Silvino Sousa, Rui Wang, Bradford L. McRae
Publikováno v: BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L expressed on T cells results in the production of
Externí odkaz: https://doaj.org/article/66a26e4226064b91872d1401b83f9517
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3
Akademický článek
Empowering therapeutic antibodies with IFN-α for cancer immunotherapy.
Autor: Jun Guo, Yu Xiao, Ramesh Iyer, Xin Lu, Marc Lake, Uri Ladror, John Harlan, Tanushree Samanta, Medha Tomlinson, Gail Bukofzer, Cherrie Donawho, Alex Shoemaker, Tzu-Hsuan Huang
Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0219829 (2019)
Type 1 IFNs stimulate secretion of IP-10 (CXCL10) which is a critical chemokine to recruit effector T cells to the tumor microenvironment and IP-10 knockout mice exhibit a phenotype with compromised effector T cell generation and trafficking. Type 1
Externí odkaz: https://doaj.org/article/704be8f1301e4ff9a3b08f374f073038
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4
Akademický článek
Whom to treat? Factors associated with chemotherapy recommendations and outcomes among patients with NHL at the Uganda Cancer Institute.
Autor: Manoj Menon, Anna Coghill, Innocent Mutyaba, Fred Okuku, Warren Phipps, John Harlan, Jackson Orem, Corey Casper
Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0191967 (2018)
INTRODUCTION:Cancer treatment options in sub-Saharan Africa are scarce despite an increasing burden of disease. Identification of those cancer patients who would benefit most from the limited resources available would allow broader and more effective
Externí odkaz: https://doaj.org/article/1f2b5463b514490da098cd8021b2dd2d
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6
Akademický článek
Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury.
Autor: Akiko Iwata, Vicki Morgan-Stevenson, Barbara Schwartz, Li Liu, Joan Tupper, Xiaodong Zhu, John Harlan, Robert Winn
Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9103 (2010)
Ischemia-reperfusion (I/R) injury contributes to organ dysfunction in a variety of clinical disorders, including myocardial infarction, stroke, organ transplantation, and hemorrhagic shock. Recent investigations have demonstrated that apoptosis as an
Externí odkaz: https://doaj.org/article/7d576248a21d43f4ac99d5e44eedffa2
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